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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Arginine Vasopressin, Synaptic Plasticity, and Brain Networks

Author(s): Anna B. Marcinkowska, Vinicia C. Biancardi and Pawel J. Winklewski*

Volume 20, Issue 12, 2022

Published on: 27 July, 2022

Page: [2292 - 2302] Pages: 11

DOI: 10.2174/1570159X20666220222143532

Price: $65

Abstract

The arginine vasopressin (AVP), a neurohypophysial hormone, is synthesized within specific sites of the central nervous system and axonally transported to multiple areas, acting as a neurotransmitter/ neuromodulator. In this context, AVP acts primarily through vasopressin receptors A and B and is involved in regulating complex social and cognition behaviors and basic autonomic function. Many earlier studies have shown that AVP as a neuromodulator affects synaptic plasticity. This review updates our current understanding of the underlying molecular mechanisms by which AVP affects synaptic plasticity. Moreover, we discuss AVP modulatory effects on event-related potentials and blood oxygen level-dependent responses in specific brain structures, and AVP effects on the network level oscillatory activity. We aimed at providing an overview of the AVP effects on the brain from the synaptic to the network level.

Keywords: arginine-vasopressin, synaptic plasticity, brain networks, neuronal oscillatory activity, blood-oxygen level-dependent activity, network-level oscillatory activity

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