Login Register Cart 0
Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Zinc, Copper, Magnesium Levels in Polycystic Ovarian Syndrome Patients

Author(s): Simmi Kharb*, Chetna Bhatotiya, Shweta Gaur, Rajni Goel*, Aparna Khadelwal and Smiti Nanda*

Volume 18, Issue 5, 2022

Published on: 02 March, 2022

Page: [498 - 501] Pages: 4

DOI: 10.2174/1573401318666220201114704

Price: $65

Abstract

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases, and the status of trace elements is not clear.

Aims and Objectives: In the present cross-sectional study, the potential relationships between serum levels of zinc, copper, magnesium, and PCOS were explored.

Materials and Methods: One hundred participants with PCOS and 100 healthy controls were studied. They were in the age group (15-35 years) with the same socio-demographic characteristics. Blood samples were drawn to estimate serum zinc, copper, and magnesium levels by autoanalyzer.

Results: Serum zinc and magnesium levels were found significantly higher among the study group as compared to the control group. Serum copper levels were significantly lower in the study group. Serum copper levels were significantly correlated with age and BMI among PCOS women. Serum magnesium and zinc levels had a maximum area under the ROC curve, and the high discriminating power of serum magnesium correlated with zinc levels for PCOS.

Conclusion: These results suggest that trace elements have a role in the pathogenesis of PCOS and that supplementation may help manage the disease.

Keywords: PCOS, trace elements, serum zinc, serum copper, serum magnesium, BMI.

« Previous Next »
Graphical Abstract

[1]
Sharif ME, Adam I, Ahmed MA, Rayis DA, Hamdan HZ. Serum level of zinc and copper in sudanese women with polycystic ovarian syndrome. Biol Trace Elem Res 2017; 180(1): 23-7.
[http://dx.doi.org/10.1007/s12011-017-1000-8] [PMID: 28316042]
[2]
Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 2013; 6: 1-13.
[http://dx.doi.org/10.2147/CLEP.S37559] [PMID: 24379699]
[3]
Cho LW, Randeva HS, Atkin SL. Cardiometabolic aspects of polycystic ovarian syndrome. Vasc Health Risk Manag 2007; 3(1): 55-63.
[PMID: 17583175]
[4]
Yamashita S, Abe A, Noma A. Sensitive, direct procedures for simultaneous determinations of iron and copper in serum, with use of 2-(5-nitro-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino) phenol (nitro-PAPS) as ligand. Clin Chem 1992; 38(7): 1373-5.
[http://dx.doi.org/10.1093/clinchem/38.7.1373] [PMID: 1623608]
[5]
Mazloomi S, Alizadeh N, Aminzare M, Niroomand S, Mousavi SN. RETRACTED ARTICLE: Serum zinc and adiponectin levels in patients with polycystic ovary syndrome, adjusted for anthropometric, biochemical, dietary intake, and physical activity measures. Biol Trace Elem Res 2018; 181(2): 388.
[http://dx.doi.org/10.1007/s12011-017-0951-0] [PMID: 28160242]
[6]
Li M, Tang Y, Lin C, Huang Q, Lei D, Hu Y. Serum macroelement and microelement concentrations in patients with polycystic ovary syndrome: a cross-sectional study. Biol Trace Elem Res 2017; 176(1): 73-80.
[http://dx.doi.org/10.1007/s12011-016-0782-4] [PMID: 27502954]
[7]
Swetha N, Vyshnavi R. P. Modagan BR. A correlative study of biochemical parameters in polycystic ovarian syndrome. Int J Biol Med Res 2013; 4: 3148-54.
[8]
Kurdoglu Z, Kurdoglu M, Demir H, Sahin HG. Serum trace elements and heavy metals in polycystic ovary syndrome. Hum Exp Toxicol 2012; 31(5): 452-6.
[http://dx.doi.org/10.1177/0960327111424299] [PMID: 22027497]
[9]
Zheng G, Wang L, Guo Z, et al. Association of serum heavy metals and trace element concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population. Biol Trace Elem Res 2015; 167(1): 1-10.
[http://dx.doi.org/10.1007/s12011-015-0294-7] [PMID: 25758722]
[10]
Revathi R, Singaravelu S. Correlation of serum copper, zinc, magnesium with insulin resistance in PCOS female of reproductive age group. Indian J Public Health Res Dev 2019; 10: 1048-51.

Rights & Permissions Print Cite
Article Metrics
13
1
© 2024 Bentham Science Publishers | Privacy Policy