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Current Aging Science

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ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

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Research Article

Neurological Disorders in an Elderly Cohort Experienced Past Stressful Events: A Retrospective-prospective Study

Author(s): Raúl O. Domínguez, Enrique R. Marschoff, Liliana M. Oudkerk, Luis E. de la Ossa Angulo, Susana Villamizar Pérez, Graciela A. Bianchi, Marisa G. Repetto and Jorge A. Serra*

Volume 15, Issue 2, 2022

Published on: 18 March, 2022

Page: [163 - 171] Pages: 9

DOI: 10.2174/1874609815666220118104234

Price: $65

Abstract

Background: Psychological stress may be a risk factor for dementia, but the association between exposure to stressful life events and the development of cognitive dysfunction has not been conclusively demonstrated. We hypothesize that if a stressful event has an impact on the subjects, its effects would be different in the three diseases.

Objective: This study aims to assess the effects of stressful events in senior patients who later developed ischemic stroke, Alzheimer's, or Parkinson's disease.

Material and Methods: Together with demographic variables (age, sex, race, socioeconomic and cultural levels), five types of past stressful events, such as death or serious illness of close relatives, job dismissal, change of financial status, retirement, and change of residence, were recorded in 1024 patients with Alzheimer's disease, Parkinson's disease, and ischemic stroke. Time-todiagnosis (months from the event to the first symptoms: retrospective study) and evolution time (years of follow-up of each patient: prospective study) were recorded. The variance and nonparametric methods were analyzed to the variables time-to-diagnosis and evolution time to analyze differences between these diseases.

Results: The demographic variables, such as age, sex, race, economic and cultural levels, were found to be statistically non-significant; differences in the economic level were significant (P<0.05). Significant differences (P<0.001) were found in the mean time-to-diagnosis between diseases (Alzheimer’s disease>Parkinson’s disease >Stroke), and minor differences (P<0.05) in evolution time.

Conclusion: Differences in time-to-diagnosis between the diseases indicate that the stressful effect of having experienced the death or serious illness of a close relative has an impact on their emergence. The measurement of time-to-diagnosis and evolution time proves useful in detecting differences between diseases.

Keywords: Stressful life events, Alzheimer´s disease, Parkinson´s disease, ischemic stroke, risk factors, neurological diseases.

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[1]
Selye H. The evolution of the stress concept. Am Sci 1973; 61(6): 692-9.
[PMID: 4746051]
[2]
Osório C, Probert T, Jones E, Young AH, Robbins I. Adapting to stress: understanding the neurobiology of resilience. Behav Med 2017; 43(4): 307-22.
[http://dx.doi.org/10.1080/08964289.2016.1170661] [PMID: 27100966]
[3]
de Lustig ES, Serra JA, Kohan S, Canziani GA, Famulari AL, Dominguez RO. Copper-zinc superoxide dismutase activity in red blood cells and serum in demented patients and in aging. J Neurol Sci 1993; 115(1): 18-25.
[http://dx.doi.org/10.1016/0022-510X(93)90062-4] [PMID: 8468588]
[4]
Serra JA, Domínguez RO, de Lustig ES, et al. Parkinson’s disease is associated with oxidative stress: comparison of peripheral antioxidant profiles in living Parkinson’s, Alzheimer’s and vascular dementia patients. J Neural Transm (Vienna) 2001; 108(10): 1135-48.
[http://dx.doi.org/10.1007/s007020170003] [PMID: 11725816]
[5]
Serra JA, Domínguez RO, Marschoff ER, Guareschi EM, Famulari AL, Boveris A. Systemic oxidative stress associated with the neurological diseases of aging. Neurochem Res 2009; 34(12): 2122-32.
[http://dx.doi.org/10.1007/s11064-009-9997-5] [PMID: 19488852]
[6]
McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007; 87(3): 873-904.
[http://dx.doi.org/10.1152/physrev.00041.2006] [PMID: 17615391]
[7]
Roozendaal B, McEwen BS, Chattarji S. Stress, memory and the amygdala. Nat Rev Neurosci 2009; 10(6): 423-33.
[http://dx.doi.org/10.1038/nrn2651] [PMID: 19469026]
[8]
McEwen BS. Plasticity of the hippocampus: adaptation to chronic stress and allostatic load. Ann N Y Acad Sci 2001; 933: 265-77.
[http://dx.doi.org/10.1111/j.1749-6632.2001.tb05830.x] [PMID: 12000027]
[9]
Bremner JD, Elzinga B, Schmahl C, Vermetten E. Structural and functional plasticity of the human brain in posttraumatic stress disorder Prog Brain Res 2008; 167: 171-86.
[http://dx.doi.org/10.1016/S0079-6123(07)67012-5] [PMID: 18037014]
[10]
Morey RA, Gold AL, LaBar KS, et al. Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group. Arch Gen Psychiatry 2012; 69(11): 1169-78.
[http://dx.doi.org/10.1001/archgenpsychiatry.2012.50] [PMID: 23117638]
[11]
Wolkowitz OM, Epel ES, Reus VI, Mellon SH. Depression gets old fast: do stress and depression accelerate cell aging? Depress Anxiety 2010; 27(4): 327-38.
[http://dx.doi.org/10.1002/da.20686] [PMID: 20376837]
[12]
Gerritsen L, Kalpouzos G, Westman E, et al. The influence of negative life events on hippocampal and amygdala volumes in old age: a life-course perspective. Psychol Med 2015; 45(6): 1219-28.
[http://dx.doi.org/10.1017/S0033291714002293] [PMID: 25273347]
[13]
Sugama S, Sekiyama K, Kodama T, et al. Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson’s disease. Brain Behav Immun 2016; 51: 39-46.
[http://dx.doi.org/10.1016/j.bbi.2015.08.015] [PMID: 26291405]
[14]
Egido JA, Castillo O, Roig B, et al. Is psycho-physical stress a risk factor for stroke? A case-control study. J Neurol Neurosurg Psychiatry 2012; 83(11): 1104-10.
[http://dx.doi.org/10.1136/jnnp-2012-302420] [PMID: 22930814]
[15]
Guiraud V, Touzé E, Rouillon F, Godefroy O, Mas JL. Stressful life events as triggers of ischemic stroke: A case-crossover study. Int J Stroke 2013; 8(5): 300-7.
[http://dx.doi.org/10.1111/j.1747-4949.2012.00810.x] [PMID: 22568432]
[16]
Surtees PG, Wainwright NW, Luben RL, Wareham NJ, Bingham SA, Khaw KT. Adaptation to social adversity is associated with stroke incidence: evidence from the EPIC-Norfolk prospective cohort study. Stroke 2007; 38(5): 1447-53.
[http://dx.doi.org/10.1161/STROKEAHA.106.473116] [PMID: 17363725]
[17]
O’Donnell MJ, Xavier D, Liu L, et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010; 376(9735): 112-23.
[http://dx.doi.org/10.1016/S0140-6736(10)60834-3] [PMID: 20561675]
[18]
Lin D. How stress can cause a fever. Nature 2020; 580(7802): 189-90.
[http://dx.doi.org/10.1038/d41586-020-00873-0] [PMID: 32231321]
[19]
Holmes TH, Rahe RH. The social readjustment rating scale. J Psychosom Res 1967; 11(2): 213-8.
[http://dx.doi.org/10.1016/0022-3999(67)90010-4] [PMID: 6059863]
[20]
Connor KM, Davidson JR. Development of a new resilience scale: the Connor-Davidson Resilience Scale (CD-RISC). Depress Anxiety 2003; 18(2): 76-82.
[http://dx.doi.org/10.1002/da.10113] [PMID: 12964174]
[21]
Pachana NA, Byrne GJ, Siddle H, Koloski N, Harley E, Arnold E. Development and validation of the geriatric anxiety inventory. Int Psychogeriatr 2007; 19(1): 103-14.
[http://dx.doi.org/10.1017/S1041610206003504] [PMID: 16805925]
[22]
Sokal RR, Rohlf FJ. Biometry. In: Freeman W.H. and Company 2nd ed 1995.
[23]
American Psychiatric Association Diagnostic and statistical manual of mental disordersText revised (DSM-IV RT). 4th Edition.. Washington, DC: American Psychiatric Press 2000.
[24]
Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140: 566-72.
[http://dx.doi.org/10.1192/bjp.140.6.566] [PMID: 7104545]
[25]
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12(3): 189-98.
[http://dx.doi.org/10.1016/0022-3956(75)90026-6] [PMID: 1202204]
[26]
Henneges C, Reed C, Chen YF, Dell’Agnello G, Lebrec J. Describing the sequence of cognitive decline in alzheimer’s disease patients: results from an observational study. J Alzheimers Dis 2016; 52(3): 1065-80.
[http://dx.doi.org/10.3233/JAD-150852] [PMID: 27079700]
[27]
Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer’s disease. Am J Psychiatry 1984; 141(11): 1356-64.
[http://dx.doi.org/10.1176/ajp.141.11.1356] [PMID: 6496779]
[28]
Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 2015; 30(12): 1591-601.
[http://dx.doi.org/10.1002/mds.26424] [PMID: 26474316]
[29]
Goetz CG, Poewe W, Rascol O, et al. Movement disorder society task force report on the hoehn and yahr staging scale: status and recommendations. Mov Disord 2004; 19(9): 1020-8.
[http://dx.doi.org/10.1002/mds.20213] [PMID: 15372591]
[30]
Hatano S. Experience from a multi-centre stroke register: A preliminary report. Bull World Health Org 1976; 54(5): 541-3.
[31]
Chaudhry M, Hasnain S, Snitz BE, et al. Association of APOE polymorphisms and stressful life events with dementia in a Pakistani population. Neurosci Lett 2014; 570: 42-6.
[http://dx.doi.org/10.1016/j.neulet.2014.04.008] [PMID: 24746929]
[32]
Escher CM, Sannemann L, Jessen F. Stress and Alzheimer’s disease. J Neural Transm (Vienna) 2019; 126(9): 1155-61.
[http://dx.doi.org/10.1007/s00702-019-01988-z] [PMID: 30788601]
[33]
Munro CA, Wennberg AM, Bienko N, Eaton WW, Lyketsos CG, Spira AP. Stressful life events and cognitive decline: Sex differences in the baltimore epidemiologic catchment area follow-up study. Int J Geriatr Psychiatry 2019; 34(7): 1008-17.
[http://dx.doi.org/10.1002/gps.5102] [PMID: 30901482]
[34]
Horínek D, Varjassyová A, Hort J. Magnetic resonance analysis of amygdalar volume in Alzheimer’s disease. Curr Opin Psychiatry 2007; 20(3): 273-7.
[http://dx.doi.org/10.1097/YCO.0b013e3280ebb613] [PMID: 17415082]
[35]
Scheperjans F, Pekkonen E, Kaakkola S, Auvinen P. Linking smoking, coffee, urate, and parkinson’s disease - a role for gut microbiota? J Parkinsons Dis 2015; 5(2): 255-62.
[http://dx.doi.org/10.3233/JPD-150557] [PMID: 25882059]
[36]
Sampson TR, Debelius JW, Thron T, et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of parkinson’s disease. Cell 2016; 167(6): 1469-1480.e12.
[http://dx.doi.org/10.1016/j.cell.2016.11.018] [PMID: 27912057]
[37]
Clark AJ, Ritz B, Prescott E, Rod NH. Psychosocial risk factors, pre-motor symptoms and first-time hospitalization with Parkinson’s disease: a prospective cohort study. Eur J Neurol 2013; 20(8): 1113-20.
[http://dx.doi.org/10.1111/ene.12117] [PMID: 23433314]
[38]
Svensson E, Farkas DK, Gradus JL, Lash TL, Sørensen HT. Adjustment disorder and risk of Parkinson’s disease. Eur J Neurol 2016; 23(4): 751-6.
[http://dx.doi.org/10.1111/ene.12933] [PMID: 26756302]
[39]
Vlajinac H, Sipetic S, Marinkovic J, et al. The stressful life events and Parkinson’s disease: a case-control study. Stress Health 2013; 29(1): 50-5.
[http://dx.doi.org/10.1002/smi.2424] [PMID: 22396022]
[40]
Saposnik G, Baibergenova A, Dang J, Hachinski V. Does a birthday predispose to vascular events? Neurology 2006; 67(2): 300-4.
[http://dx.doi.org/10.1212/01.wnl.0000217915.06544.aa] [PMID: 16728650]
[41]
Henderson KM, Clark CJ, Lewis TT, et al. Psychosocial distress and stroke risk in older adults. Stroke 2013; 44(2): 367-72.
[http://dx.doi.org/10.1161/STROKEAHA.112.679159] [PMID: 23238864]
[42]
Booth J, Connelly L, Lawrence M, et al. Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis. BMC Neurol 2015; 15: 233.
[http://dx.doi.org/10.1186/s12883-015-0456-4] [PMID: 26563170]
[43]
Fransson EI, Nyberg ST, Heikkilä K, et al. Job strain and the risk of stroke: an individual-participant data meta-analysis. Stroke 2015; 46(2): 557-9.
[http://dx.doi.org/10.1161/STROKEAHA.114.008019] [PMID: 25563644]
[44]
Sumner JA, Edmondson D. Refining our understanding of PTSD in medical settings. Gen Hosp Psychiatry 2018; 53: 86-7.
[http://dx.doi.org/10.1016/j.genhosppsych.2018.05.001] [PMID: 29778269]
[45]
Kronenberg G, Schöner J, Levitanus M, et al. The importance of previous lifetime trauma in stroke-induced PTSD symptoms and mental health outcomes. J Psychiatr Res 2021; 136: 589-94.
[http://dx.doi.org/10.1016/j.jpsychires.2020.10.033] [PMID: 33143861]
[46]
McEwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 1998; 840: 33-44.
[http://dx.doi.org/10.1111/j.1749-6632.1998.tb09546.x] [PMID: 9629234]
[47]
Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002; 53(4): 865-71.
[http://dx.doi.org/10.1016/S0022-3999(02)00429-4] [PMID: 12377295]

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