Host Microbiomes in Tumor Precision Medicine: How far are we?

doi:10.2174/0929867329666220105121754
摘要

近年来，由于对包括癌症在内的人类病理生理学的无数影响，人类肠道微生物群受到了越来越多的关注。对癌症和抗癌治疗的研究正在不断寻找新的提示，以提高对治疗的反应，同时降低复发的风险。在这种情况下，肠道微生物群和大量的微生物衍生代谢物被认为是开发创新的抗癌治疗方法的新开放，以获得更好的预后。这篇综述总结了目前关于肠道微生物群在癌症的发生和进展以及对化疗免疫治疗的反应中的作用的知识。最近的发现关于肿瘤微生物组和它的临床实践的影响也评论。目前以微生物组为基础的干预策略(即。然后讨论了益生元、益生菌、活体生物疗法和粪便微生物群移植)，以及关键的缺点，包括缺乏已经被标准治疗严重损害的患者的长期安全信息。应用于微生物学和其他组学数据的生物信息学工具的实施，如机器学习，具有推动该领域研究的巨大潜力，使健康风险和治疗结果成为预测，从而实现真正个性化的精准医疗。
关键词: 肠道微生物组，微生物代谢物，肿瘤微生物组，抗癌治疗，益生菌，粪便微生物群移植，下一代益生菌，机器学习。
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DOI https://dx.doi.org/10.2174/0929867329666220105121754	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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