Abstract
Background: Lopinavir and Ritonavir are protease inhibitor type of anti-retroviral drugs. Both are used for the treatment of HIV/AIDS. This paper reviews many analytical methods for the analysis of LPV and RTV in pharmaceutical formulations (tablet, capsule, syrup, and bulk) and biological fluids (human plasma, serum, cerebrospinal fluid, rat plasma, and human hair).
Objective: The study aims to summarize various analytical techniques, such as chromatography and spectrophotometry, and also hyphenated techniques, such as LC-MS/MS and UPLC-MS, for the analysis of Lopinavir and Ritonavir.
Methods: The review deals with comprehensive details regarding the type of various analytical techniques, such as spectroscopy (UV), chromatography (RP-HPLC, HPTLC, UPLC), and hyphenated techniques, i.e., LC-MS/MS and UPLC-MS, for the analysis of lopinavir and ritonavir. These techniques are either explored for the quantification and detection of metabolite or for stability studies of the LPV and RTV.
Conclusion: The studies presented revealed that the HPLC technique along with spectroscopy have been most widely used for the analysis. Out of the developed methods, hyphenated UPLCMS and LC-MS are very sensitive and help in the easy estimation of drugs compared to other techniques. This review may provide comprehensive details to the researchers working in the area of analytical research of LPV and RTV.
Keywords: Ritonavir, lopinavir, anti-retroviral, aids, analytical methods, analytical techniques.
Graphical Abstract
[1]
Varaprasad, B.; Baba, H.; Ravikumar, A.; Vijaykumar, G. Development method validation of RP-HPLC method for simultaneous determination of lopinavir and ritonavir in bulk and formulation dosage. Int. Res. J. Pharm. Appl. Sci., 2012, 2(4), 84-90.
[2]
Dhulipalli, S.B.; Prasad, K.; Alegete, P.; Rao Seshagiri, J.V.L.N. Quality by design (qbd) approach prior to the validation for simultaneous estimation of related substances in lopinavir- ritonavir soft gelatin capsules by high performance liquid chromatography. JOAC, 2016, 5(2), 393-403.
[3]
Rathnasamy, R.; Karuvalam, R.P.; Pakkath, R.; Kamalakannan, P.; Sivasubramanian, A. RP-HPLC method development and method validation of lopinavir and ritonavir in pharmaceutical dosage form. Am. J. Clin. Microbiol. Antimicrob., 2018, 1(1), 1002.
[4]
Punagoti, R.A.; Rao, V.J. Development and validation of a RP-HPLC method for simultaneous determination of ritonavir and lopinavir in combined dosage form. Anal. Chem. Indian J., 2014, 14(3), 88-92.
[5]
Sunitha, N.; Marihal, S.C.; Vasanthi, C.; Venu, A.; Rao, B.N.; Rao, B.A. Method development and validation of stability indicating RP-HPLC method for simultaneous estimation of ritonavir and lopinavir in pure and pharmaceutical dosage form. Int. J. Adv. Res. (Indore), 2015, 3(5), 649-657.
[6]
Thakkar, H.; Patel, K. A first-derivative spectrophotometric method for the estimation of Lopinavir in tablets. Chron. Young Sci., 2010, 1(3), 22.
[7]
Sunkara, N.; Vijayalakshmi, A. UV spectrophotometric method development and validation of lopinavir in bulk and in pharmaceutical dosage form. CIBTech. J. Pharm. Sci., 2017, 6(2), 1-4.
[8]
Trivedi, C.D.; Mardia, R.B.; Suhagia, B.N.; Chauhan, S.P. Development and validation of spectrophotometric method for the estimation of ritonavir in tablet dosage form. Int. J. Pharm. Sci. Res., 2013, 4(12), 4567.
[9]
Acharyulu, M.L.; Murthy, C.V.; Reddy, T.S.; Prasad, S.M.; Ashok, S. Research article spectrophotometric determination of ritonavir by condensation method using ninhydrin and ascorbic acid. Int. J. Appl. Biol. Pharm. Technol., 2012, 4(1), 53.
[10]
Chiranjeevi, K.; Channabasavaraj, K.P.; Reddy, P.S.; Nagaraju, P.T. Development and validation of spectrophotometric method for quantitative estimation of ritonavir in bulk and pharmaceutical dosage forms. Int. J. Chemtech Res., 2011, 3(1), 58-62.
[11]
Seetaramaiah, K.; Smith, A.A.; Ramyateja, K.; Alagumanivasagam, G.; Manavalan, R. Spectrophotometric determination of ritonavir in bulk and pharmaceutical formulation. Sci. Rev. Chem. Commun., 2012, 2, 1-6.
[12]
Peerzade, M.Y.; Memon, S.; Bhise, K.; Aamer, A.I. Development and validation of UV-Visible spectrophotometric method for estimation of ritonavir in bulk and formulation. Pharm. Innov. J., 2019, 8(4), 30-34.
[13]
Behera, A.; Moitra, S.K.; Chandra Si, S.; Meher, A.K.; Sankar, A.P. Method development, validation and stability study of ritonavir in bulk and pharmaceutical dosage form by spectrophotometric method. Chron. Young Sci., 2011, 2(3), 161.
[http://dx.doi.org/10.4103/2229-5186.90894]
[http://dx.doi.org/10.4103/2229-5186.90894]
[14]
Dias, C.L.; Bergold, A.M.; Froehlich, P.E. UV-derivative spectrophotometric determination of ritonavir capsules and comparison with LC method. Anal. Lett., 2009, 42(12), 1900-1910.
[http://dx.doi.org/10.1080/00032710903060701]
[http://dx.doi.org/10.1080/00032710903060701]
[15]
Dinakaran, S.K.; Botla, D.N.; Pothula, A.; Kassetti, K.; Avasarala, H.; Kakaraparthy, R. Spectrophotometric method development and validation for valacyclovir hydrochloride monohydrate and ritonavir in bulk and tablet dosage form using absorption ratio method. Malays. J. Pharm. Sci., 2013, 11(2), 21.
[16]
Nimje, H.; Kore, P.; Wankhede, S.; Gadekar, A. Simultaneous estimation of darunavir ethanolate and ritonavir in combined dosage form. Int. J. Acad. Res. Dev., 2017, 2(6), 218-222.
[17]
Patil, P.M.; Kannapurkar, S.S. Development and validation of UV-Spectrophotometric method for simultaneous determination of atazanvir sulphate and ritonavir in its pure and pharmaceutical dosage forms. Int. J. Med. Res. Pharm. Sci., 2016, 6(1), 79-86.
[18]
Sri, K.V.; Deepthi, S.; Madhuri, M.; Aishwarya, P.V. Development and validation of UV spectroscopic by Q-absorption ratio, RP-HPLC method for simultaneous estimation of atazanvir and ritonavir in bulk and pharmaceutical dosage form. Asian J. Pharm. Anal., 2019, 9(3), 138-150.
[http://dx.doi.org/10.5958/2231-5675.2019.00026.7]
[http://dx.doi.org/10.5958/2231-5675.2019.00026.7]
[19]
Vasavi, N.; Patan, A. Method development and validation for the simultaneous estimation of Atazanavir and Ritonavir in tablet dosage form by RP-HPLC. Indian J. Res. Pharm. Biotechnol., 2013, 1(6), 808.
[20]
Patel, D.A.; Patel, B.N.; Patel, C.N. Spectrophotometric method for simultaneous estimation of atazanavir sulfate and ritonavir in tablet dosage form. Drug Develop. Therap., 2015, 6(1), 1.
[http://dx.doi.org/10.4103/2394-2002.148880]
[http://dx.doi.org/10.4103/2394-2002.148880]
[21]
Ponnilavarasan, I.; Rajasekaran, A.; Dharuman, J.G.; Kalaiyarasi, D.; Krishnakumar, D. Development and validation of spectrophotometric method for the estimation of lopinavir and ritonavir in tablet dosage form. Asian J. Res. Chem, 2010, 3(1), 188-191.
[22]
Devineni, J.; Rangani, V.; Nunna, S. New sensitive UV spectrophotometric method for simultaneous estimation of lopinavir and ritonavir in fixed dose combination as softgels. Int. J. Pharm. Develop. Technol., 2016, 7(1), 25-30.
[23]
Jadhav, S.R.; Alhat, H.P.; Joshi, S. Analytical methods development & validation for simultaneous estimation of lopinavir & ritonavir in pharmaceutical formulation by simultaneous equation method using UV spectrophotometry. Int. Res. J. Pharm., 2018, 9(8), 57-62.
[http://dx.doi.org/10.7897/2230-8407.098165]
[http://dx.doi.org/10.7897/2230-8407.098165]
[24]
Phechkrajang, C.M.; Thin, E.E.; Sratthaphut, L.; Nacapricha, D.; Wilairat, P. Chemometrics-Assisted UV spectrophotometric method for determination of Lopinavir and Ritonavir in syrup. Int. J. Pharm. Pharm. Sci., 2011, 4(Suppl. 1), 492-496.
[25]
Poornima, B.; Reddy, P.J.; Neelima, D.S.S.N. Method development and validation for the simultaneous determination of Ritonavir and Lopinavir by RP-HPLC and by UV- Spectrophotometry. Int. J. Pharm. Anal. Res., 2019, 8(2), 227-228.
[26]
Salunke, J.M.; Pawar, D.S.; Chavhan, V.D.; Ghante, M.R. Simultaneous UV spectrophotometric method for estimation of ritonavir and lopinavir in bulk and tablet dosage form. Scholars Res. Library Der Pharm. Lett., 2013, 5(3), 156-162.
[27]
Nagulwar, V.P.; Bhusari, K.P. Simultaneous estimation of ritonavir and lopinavir by absorption ratio (Q-analysis) UV spectrophotometric method in combined tablet dosage form. Pharm. Lett., 2010, 2(1), 196-200.
[28]
Sangshetti, J.N.; Bhojane, S.; Rashid, S.B.; Gonjari, I. Spectrophotometric method for simultaneous estimation of lopinavir and ritonavir in bulk and tablet dosage form. Int. J. Chemtech Res., 2014, 6(1), 823-827.
[29]
Bhavyasri, K.; Sreshta, M.; Sumakanth, M. Simultaneous method development and validation of UV-visible spectrophotometric method for estimation darunavir and ritonavir of in spiked human plasma. Aut Aut Res. J., 2020, 11(4), 116-131.
[30]
Abdelhay, M.H.; Gazy, A.A.; Shaalan, R.A.; Ashour, H.K. Validated stability-indicating HPLC and HPTLC methods for the determination of ritonavir in bulk powder and in capsules. Yao Wu Shi Pin Fen Xi, 2012, 20(4), 963-973.
[31]
Sudha, T.; Vanitha, R.; Ganesan, V. Development and validation of RP-HPLC and HPTLC methods for estimation of ritonavir in bulk and in pharmaceutical formulation. Pharma Chem., 2011, 3(2), 127-134.
[32]
Behera, A.; Sethy, K.; Sankar, D.G.; Moitra, S.K.; Si, S.C. Statistical correlation and simultaneous estimation of Atazanavir sulfate and Ritonavir in fixed dosage form by high performance liquid chromatography and high performance thin layer chromatography. J. Liq. Chromatogr. Relat. Technol., 2012, 35(12), 1731-1749.
[http://dx.doi.org/10.1080/10826076.2011.621774]
[http://dx.doi.org/10.1080/10826076.2011.621774]
[33]
Induri, M.; Mantripragada, B.R.; Yejella, R.P. Simultaneous estimation of atazanvir and ritonavir in tablet doasage form by HPTLC method. Int. J. Pharm., 2014, 4(2), 219-224.
[34]
Deshpande, P.B.; Butle, S.R. Stability indicating high performance thin layer chromatographic method for determination of atazanvir and ritonavir in combined tablet dosage forms. J. Pharm. Sci. Innov., 2014, 3(5), 468.
[http://dx.doi.org/10.7897/2277-4572.035197]
[http://dx.doi.org/10.7897/2277-4572.035197]
[35]
Gadhvi, M.; Bhandari, A.; Suhagia, B.; Rathod, I.; Desai, U.; Patwari, A.; Variya, K. Simultaneous determination of ritonavir and atazanavir in combined tablet dosage form by HPTLC. Asian J. Biomed. Pharm. Sci., 2012, 2(15), 15.
[36]
Deshpande, P.; Butle, S. Development and validation of stability-indicating HPTLC method for determination of darunavir ethanolate and ritonavir. Int. J. Pharm. Pharm. Sci., 2014, 7(6), 66-71.
[37]
Ibrahim, A.E.; Saraya, R.E.; Saleh, H.; Elhenawee, M. Development and validation of eco-friendly micellar-HPLC and HPTLC-densitometry methods for the simultaneous determination of paritaprevir, ritonavir and ombitasvir in pharmaceutical dosage forms. Heliyon, 2019, 5(4), e01518.
[http://dx.doi.org/10.1016/j.heliyon.2019.e01518] [PMID: 31049430]
[http://dx.doi.org/10.1016/j.heliyon.2019.e01518] [PMID: 31049430]
[38]
Sangshetti, J.N.; Bhojane, S.; Rashid, B.S.; Zaheer, Z.; Ahmed, R.Z.; Gonjari, I.; Battase, A.P. Simultaneous estimation of lopinavir and ritonavir in bulk and dosage form by HPTLC. World J. Pharm. Pharm. Sci., 2014, 3(3), 926-933.
[39]
Patel, D.J.; Desai, S.D.; Savaliya, R.P.; Gohil, D.Y. Simultaneous HPTLC determination of lopinavir and ritonavir in combined dosage form. Asian J. Pharm. Clin. Res., 2011, 4(1), 59-61.
[40]
Fegade, J.D.; Chawla, N.D.; Chaudhari, R.Y.; Patil, V.R. Article details high-performance thin layer chromatographic method for the simultaneous quantitation of lopinavir and ritonavir in tablet formulation. Indian Drugs, 2012, 50(1), 23-29.
[http://dx.doi.org/10.53879/id.50.01.p0023]
[http://dx.doi.org/10.53879/id.50.01.p0023]
[41]
Patel, G.F.; Vekariya, N.R.; Bhatt, H.S. Application of TLC-densitometry method for simultaneous determination of lopinavir and ritonavir in capsule dosage form. Orient. J. Chem., 2009, 25(3), 727-730.
[42]
Mardia, R.B.; Suhagia, B.N.; Pasha, T.Y.; Chauhan, S.P.; Solanki, S.D. Development and validation of HPTLC method for simultaneous analysis of lopinavir and ritonavir in their combined tablet dosage form. Int. J. Pharm. Res. Schol., 2012, 1(1), 39-44.
[http://dx.doi.org/10.31638/IJPRS.V1.I1.00017]
[http://dx.doi.org/10.31638/IJPRS.V1.I1.00017]
[43]
Sulebhavikar, A.V.; Pawar, U.D.; Mangoankar, K.V.; Prabhu-Navelkar, N.D. HPTLC method for simultaneous determination of lopinavir and ritonavir in capsule dosage form. E-J. Chem., 2008, 5(4), 706-712.
[http://dx.doi.org/10.1155/2008/539849]
[http://dx.doi.org/10.1155/2008/539849]
[44]
Bhalerao, M.; Walode, S. HPTLC method development and validation for the estimation of Lopinavir and Ritonavir in capsule dosage form. Pharm. Sin., 2014, 5(5), 56-60.
[45]
Varma, S.M.; Vijayalakshmi, R.; Dhanaraju, M.D. Development and validation of RP-HPLC method for determination of Lopinavir in bulk and pharmaceutical dosage form. Int. J. Res. Pharm. Chem., 2012, 2(2), 413-417.
[46]
Namratha, S.; Vijayalakshmi, A. Method development and validation of lopinavir in tablet dosage form using reversed-phase high-performance liquid chromatography. Asian J. Pharm. Clin. Res., 2018, 11(4), 125-128.
[http://dx.doi.org/10.22159/ajpcr.2018.v11s4.31715]
[http://dx.doi.org/10.22159/ajpcr.2018.v11s4.31715]
[47]
Reddy, E.R.; Bharadwaj, S.A.; Jeevan, N.; Venkateshwarlu, E.; Goverdhan, P. Development and validation of RP-HPLC method for protease inhibitor-ritonavir. J. Chem. Pharm. Sci., 2011, 4(3), 111-113.
[48]
Geetha, B.K.; Srinivasn, N.; Devi, G.N.; Ramachandran, D. Development and validation of RP-LC method for ritonavir in pharmaceutical formulations. Int. J. Pharm. Pharm. Res., 2016, 7(3), 115-125.
[49]
Chiranjeevi, K.; Channabasavaraj, K.P. Development and validation of RP-HPLC method for quantitative estimation of ritonavir in bulk and pharmaceutical dosage forms. Int. J. Pharm. Sci. Res., 2011, 2(3), 596.
[50]
Neelima, K.S.S.N.; Rao, L.S.P. Development and validation of new analytical methods for the estimation of ritonavir in bulk and pharmaceutical dosage forms. Int. J. Pharm. Res. Health Sci., 2017, 5(S5), 436-440.
[51]
Gandhi, S.V.; Korhale, R.R. A RP-HPLC Method development and validation for the estimation of ritonavir in bulk and pharmaceutical dosage Form. J. Chem. Pharm. Res., 2016, 8(7), 901-904.
[52]
Shankar, C.H.; Bhikshapathi, D.V.R.N.; Suthakaran, R.; Padmaja, C.H.P.; Wahab, A. Development and validation of RP-HPLC method for ritonavir in bulk and pharmaceutical dosage forms. Int. J. Pharm. Analy. Res., 2018, 7(2), 158-164.
[53]
Jeyabaskaran, M.; Rambabu, C.; Sree, J.V.; Anitha, G.; Uma, P.T.; Maheswaran, K. RP-HPLC method development and method validation of ritonavir in bulk and pharmaceutical dosage forms. J. Pharmacreations., 2016, 3(1), 1-7.
[54]
Nagaraju, P.T.; Sreekanh, R.K.; Chinna, G.P.; Venugopal, N.; Ravindranath, S.; Bhanu, P.B.; Sade, S. Reverse phase HPLC method for determination of ritonavir in pharmaceutical preparations. Int. J. Pharm. Sci. Res., 2012, 13, 55-57.
[55]
Prathap, B.; Haribhaskar, V.; Kumar, B.; Harika, S.; Kavitha, M.; Bhavya, C. Stability indicating RP-HPLC method for simultaneous estimation of ritonavir and darunavir in bulk and its synthetic mixture. J. Glob. Trends Pharm. Sci., 2018, 9(2), 5549-5560.
[56]
Gade, B.R.; Bandhakavi, S.R.; Ramanaiah, G.; Satyanarayana, M.V. Method development and validation of stability indicating RP-HPLC method for simultaneous estimation of atazanavir and ritonavir in bulk and its pharmaceutical formulations. Res. J. Pharm. Biol. Chem. Sci., 2015, 6(3), 1455-1464.
[57]
Gadhvi, M.P.; Bhandari, A.; Suhagia, B.N.; Desai, U.H. Development and Validation of RP-HPLC method for Simultaneous estimation of Atazanavir and Ritonavir in their combined tablet dosage form. Res. J. Pharm. Technol., 2013, 6(2), 200-203.
[58]
Deshpande, P.B.; Butle, S.R. Development and validation of stability-indicating rp-hplc method for determination of atazanavir and ritonavir. Res. J. Pharm. Technol., 2014, 7(11), 1231-1236.
[59]
Subramaniam, A.T.; Munusamy, J.; Sengodan, S.; Danapal, K.; Lakshmi, H.D.; Kunan, V.S. RP-HPLC Method Development and Validation for the simultaneous estimation of Atazanavir sulphate and Ritonavir in bulk and tablet dosage form. Pharm. Chem. J., 2014, 1(3), 50-S4.
[http://dx.doi.org/10.14805/jphchem.2014.art19]
[http://dx.doi.org/10.14805/jphchem.2014.art19]
[60]
Banda, S.; Gandu, S.; Mateti, A.; Kulkarni, R.G.; Ahmed, R.; Kumar, K.S. Method develoment and validation for the simultaneous estimation of arazanavir and ritonavir in tablet dosage form by RP-HPLC and UV spectroscopy. J. Pharm. Biol. Sci., 2017, 12(6), 33-38.
[61]
Alagar, R.M.; Rao, K.N.; Banji, D.; Kumar, S.D. Simultaneous estimation of method devolopment and validation of atazanavir and ritonavir by RP-HPLC method. Asian J. Pharm. Analy. Med. Chem., 2015, 3(3), 89-99.
[62]
Kumar, M.S.; Rani, B.S.; Mounika, N.; Mamatha, J.; Kumar, J.K. A Validated RP-HPLC method for the simultaneous estimation of atazanavir and ritonavir in pharmaceutical dosage forms. ARC J. Pharm. Sci., 2016, 2(1), 21-31.
[63]
Baje, S.I.; Jyothi, B.; Madhavi, N. RP-HPLC Method for simultaneous estimation of ritonavir, ombitasvir and paritaprevir in tablet dosage forms and their stress degradation studies. Int. J. Appl. Pharm., 2019, 11(2), 193-210.
[http://dx.doi.org/10.22159/ijap.2019v11i2.28141]
[http://dx.doi.org/10.22159/ijap.2019v11i2.28141]
[64]
Styadev, T.N.V.S.S. Rp-hplc method development and validation for simultaneous estimation of ritonavir and fosamprenavir in drug product. European J. Biomed. Pharm. Sci., 2018, 5(6), 790-795.
[65]
Kumar, D.S.; Prashanthi, B.N.; Harani, A.; Anusha, P. Method Development and validation of valacyclovir hydrochloride and ritonavir in tablet dosage form using reverse phase high performance liquid chromatography. J. Teknol., 2015, 76(1), 39-45.
[66]
Al-Zoman, N.Z.; Maher, H.M.; Al-Subaie, A. Simultaneous determination of newly developed antiviral agents in pharmaceutical formulations by HPLC-DAD. Chem. Cent. J., 2017, 11(1), 1-8.
[http://dx.doi.org/10.1186/s13065-016-0232-6] [PMID: 28101128]
[http://dx.doi.org/10.1186/s13065-016-0232-6] [PMID: 28101128]
[67]
Donato, E.M.; Dias, C.L.; Rossi, R.C.; Valente, R.S.; Fröehlich, P.E.; Bergold, A.M. LC method for studies on the stability of lopinavir and ritonavir in soft gelatin capsules. Chromatographia, 2006, 63(9), 437-443.
[http://dx.doi.org/10.1365/s10337-006-0785-y]
[http://dx.doi.org/10.1365/s10337-006-0785-y]
[68]
Dubey, S.S.; Duggirala, M. Stability Indicating high performance liquid chromatographic estimation of ritonavir and lopinavir in their combined tablet dosage form. J. Pharma Res., 2015, 4(6), 237-242.
[69]
Arun, R.; Anton, A.S. Development and validation of analytical method for lopinavir and ritonavir by HPLC. Int. J. Drug Develop. Res., 2013, 5(2), 1166-1171.
[70]
Kumar, V.G.; Rajendra, N.P. Analytical method development and validation by RP-HPLC for simultaneius estimation of lopinavir and ritonavir in combined dosage form. Pharm. Res. Library, 2020. Available from: https://www.pharmaresearchlibrary.com/analy-tical-method-development-and-validation-by-rp-hplc-for-simultan-eous-estimation-of-lopinavir-and-ritonavir-in-combined-tablet-dosage-form/
[71]
Dasari, V.; Awen, B.Z.; Chandu, B.R.; Khagga, M.; Pappula, N. A validated reverse phase HPLC method for the simultaneous estimation of ritonavir and lopinavir in pharmaceutical dosage forms. Asian J. Res. Chem, 2013, 3(3), 805-808.
[72]
Kumar, A.K.; Chaitanya, K.K.; Babu, N.S. A novel isocratic RP-HPLC method development & validation of lopinavir and ritonavir. J. Glob. Trends Pharm. Sci., 2012, 3(4), 853-855.
[73]
Raghu, P.S. Stability indicating and validation for simultaneous of lopinavir and ritonavir by using RP-HPLC. World J. Pharm. Res., 2018, 7(3), 1750-1757.
[74]
Hiremath, S.N.; Bhirud, C.H. Development and validation of a stability indicating HPLC method for the simultaneous analysis of lopinavir and ritonavir in fixed-dose combination tablets. J. Taibah Univ. Med. Sci., 2015, 10(3), 271-277.
[http://dx.doi.org/10.1016/j.jtumed.2014.11.006]
[http://dx.doi.org/10.1016/j.jtumed.2014.11.006]
[75]
Jagadeeswaran, M.; Gopal, N.; Kumar, K.P.; Kumar, T.S. Quantitative estimation of lopinavir and ritonavir in tablets by RP-HPLC method. Pharm. Anal. Acta, 2012, 3(5), 1-3.
[76]
Ponnilavarasan, I.; Rajasekaran, A.; Dharuman, J.G.; Kalaiyarasi, D.; Senthilkumar, M. RP–HPLC method for simultaneous estimation of antiretroviral drugs lopinavir and ritonavir in tablet dosage form. Dig. J. Nanomater. Biostruct., 2010, 5(3), 771-778.
[77]
Suneetha, A.; Kathirvel, S.; Ramachandrika, G. A validated RP HPLC method for simultaneous estimation of lopinavir and ritonavir in combined dosage form. Int. J. Pharm. Pharm. Sci., 2010, 3(1), 49-51.
[78]
Rane, S.S.; Chaudhari, R.Y.; Patil, V.R. Method Development and Validation of antiviral combination as ritonavir and lopinavir in bulk and pharmaceutical dosage form by RP-HPLC. Res. J. Pharm. Biol. Chem. Sci., 2015, 6(5), 982-987.
[79]
Ayeen, F.Q.; Yasmeen, R.; Badar, H. Development and validation of RP-HPLC method for determination of ritonavir and lopinavir. Res. J. Pharm. Technol., 2019, 12(7), 3413-3417.
[http://dx.doi.org/10.5958/0974-360X.2019.00577.8]
[http://dx.doi.org/10.5958/0974-360X.2019.00577.8]
[80]
Phechkrajang, C.M.; Thin, E.E.; Sratthaphut, L.; Nacapricha, D.; Wilairat, P. Quantitative determination of lopinavir and ritonavir in syrup preparation by liquid chromatography. Mahidol Univ. J. Pharmaceut. Sci., 2009, 36(1-4), 1-12.
[81]
Sravani, M.V.D.; Rao, P.V.; Babu, S.A.M.S.; Jasinth, D. Method development and validation of ritonavir and lopinavir in bulk and dosage form by RP-HPLC. Int. J. Pharmaceut. Health Care Res., 2013, 1(3), 109-116.
[82]
Jeyabaskaran, M.; Rambabu, C.; Sree, J.V.; Maneka, L.S.; Hemanth, S.P. A newly validated HPLC method development for simultaneous estimation of ritonavir and lopinavir. Int. J. Pharmaceut. Investig. Res., 2015, 2(1), 1-8.
[83]
Lawson-Wood, K.; Saunders, K. HPLC Analysis of Lopinavir and Ritonavir Using a Quasar C8 Column.In: Liquid Chromatography; Perkin Elmer, Inc.: Seer Green, UK, 2020.
[84]
Kumar, K.V.; Sudhakar, M.; Reddy, Y.P.; Malleshwari, P.; Hafeez, S.K. RP-HPLC method development and validation for simultaneous estimation of lopinavir and ritonavir in dosage form and in plasma. Int. J. Pharm. Sci. Rev. Res., 2014, 3(9), 1-8.
[85]
Bindu, M.J.; Reddy, K.N.; Himabindu, G. RP-HPLC method development and validation for simultaneous estimation of Lopinavir and Ritonavir in tablet dosage form. IJRPB, 2017, 5(1), 77-79.
[86]
Babu, S.G.; Malathi, P.S. Analytical method development and validation for the simultaneous estimation of lopinavir and ritonavir by RP-HPLC method. J. Curr. Res., 2017, 2(2), 13-17.
[87]
Kumar, P.J.; Murthy, T.E.G.K.; Ryali, J.; Nagaraju, P. Validated reverse phase HPLC method for the simultaneous estimation of lopinavir and ritonavir in pharmaceutical dosage forms. Asian J. Chem., 2011, 4(8), 2819-2821.
[88]
Walode, S.G.; Bhalerao, M.R. Stability indicating RP-HPLC method for simultaneous estimation of lopinavir and ritonavir. Pelagia Research Library Der Pharmacia Sinica., 2014, 5(5), 61-66.
[89]
Rebiere, H.; Mazel, B.; Civade, C.; Bonnet, P.A. Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 850(1-2), 376-383.
[http://dx.doi.org/10.1016/j.jchromb.2006.12.007] [PMID: 17196448]
[http://dx.doi.org/10.1016/j.jchromb.2006.12.007] [PMID: 17196448]
[90]
Vats, R.; Murthy, A.N.; Ravi, P.R. Simple, rapid and validated LC determination of lopinavir in rat plasma and its application in pharmacokinetic studies. Sci. Pharm., 2011, 79(4), 849-863.
[http://dx.doi.org/10.3797/scipharm.1107-24] [PMID: 22145109]
[http://dx.doi.org/10.3797/scipharm.1107-24] [PMID: 22145109]
[91]
Marsh, K.C.; Eiden, E.; McDonald, E. Determination of ritonavir, a new HIV protease inhibitor, in biological samples using reversed-phase high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl., 1997, 704(1-2), 307-313.
[http://dx.doi.org/10.1016/S0378-4347(97)00454-4] [PMID: 9518164]
[http://dx.doi.org/10.1016/S0378-4347(97)00454-4] [PMID: 9518164]
[92]
Hoetelmans, R.M.; van Essenberg, M.; Profijt, M.; Meenhorst, P.L.; Mulder, J.W.; Beijnen, J.H. High-performance liquid chromatographic determination of ritonavir in human plasma, cerebrospinal fluid and saliva. J. Chromatogr. B Biomed. Sci. Appl., 1998, 705(1), 119-126.
[http://dx.doi.org/10.1016/S0378-4347(97)00500-8] [PMID: 9498678]
[http://dx.doi.org/10.1016/S0378-4347(97)00500-8] [PMID: 9498678]
[93]
Kumar, H.; Sudha, V.; Leelavathi, A.; Ramachandran, G. A rapid isocratic high-performance liquid chromatography (HPLC-UV) method for the quantification of ritonavir in human plasma. Int. J. Pharm. Pharm. Sci., 2016, 8(7), 64-68.
[94]
Albert, V.; Modamio, P.; Lastra, C.F.; Mariño, E.L. Determination of saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography and the analytical error function. J. Pharm. Biomed. Anal., 2004, 36(4), 835-840.
[http://dx.doi.org/10.1016/j.jpba.2004.08.013] [PMID: 15533677]
[http://dx.doi.org/10.1016/j.jpba.2004.08.013] [PMID: 15533677]
[95]
Patchala, A.; Nadendla, R. Quantification of atazanavir and ritonavir in human plasma samples by Rp-HPLC include method of detection in the title, Eg: Using PDA detection. Int. J. Life Sci. Pharma Res., 2020, 10(2), 26-33.
[http://dx.doi.org/10.22376/ijpbs/lpr.2020.10.2.P26-33]
[http://dx.doi.org/10.22376/ijpbs/lpr.2020.10.2.P26-33]
[96]
Kou, H.; Ye, M.; Fu, Q.; Han, Y.; Du, X.; Xie, J.; Zhu, Z.; Li, T. Simultaneous quantification of lopinavir and ritonavir in human plasma by high performance liquid chromatography coupled with UV detection. Sci. China Life Sci., 2012, 55(4), 321-327.
[http://dx.doi.org/10.1007/s11427-012-4303-1] [PMID: 22566088]
[http://dx.doi.org/10.1007/s11427-012-4303-1] [PMID: 22566088]
[97]
Mardia, R.B.; Suhagia, B.N.; Pasha, T.Y.; Chauhan, S.P. RP-HPLC method for simultaneous estimation of lopinavir and ritonavir in combined tablet dosageform and in spiked human plasma. Int. J. Pharm. Sci. Res., 2014, 5(8), 3443-3454.
[98]
Ray, J.; Pang, E.; Carey, D. Simultaneous determination of indinavir, ritonavir and lopinavir (ABT 378) in human plasma by high-performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2002, 775(2), 225-230.
[http://dx.doi.org/10.1016/S1570-0232(02)00295-7] [PMID: 12113989]
[http://dx.doi.org/10.1016/S1570-0232(02)00295-7] [PMID: 12113989]
[99]
Phani, ChP.R.; Prasad, K.R.; Mallu, U.R. New analytical HPLC method development and validation for the simultaneous quantification of paritaprevir ombitasvir and ritonavir in spiked human plasma. Orient. J. Chem., 2017, 33(5), 2363-2369.
[http://dx.doi.org/10.13005/ojc/330528]
[http://dx.doi.org/10.13005/ojc/330528]
[100]
Langmann, P.; Klinker, H.; Schirmer, D.; Zilly, M.; Bienert, A.; Richter, E. High-performance liquid chromatographic method for the simultaneous determination of HIV-1 protease inhibitors indinavir, saquinavir and ritonavir in plasma of patients during highly active antiretroviral therapy. J. Chromatogr. B Biomed. Sci. Appl., 1999, 735(1), 41-50.
[http://dx.doi.org/10.1016/S0378-4347(99)00388-6] [PMID: 10630889]
[http://dx.doi.org/10.1016/S0378-4347(99)00388-6] [PMID: 10630889]
[101]
Usami, Y.; Oki, T.; Nakai, M.; Sagisaka, M.; Kaneda, T. A simple HPLC method for simultaneous determination of lopinavir, ritonavir and efavirenz. Chem. Pharm. Bull. (Tokyo), 2003, 51(6), 715-718.
[http://dx.doi.org/10.1248/cpb.51.715] [PMID: 12808252]
[http://dx.doi.org/10.1248/cpb.51.715] [PMID: 12808252]
[102]
Hugen, P.W.; Verweij-van Wissen, C.P.; Burger, D.M.; Wuis, E.W.; Koopmans, P.P.; Hekster, Y.A. Simultaneous determination of the HIV-protease inhibitors indinavir, nelfinavir, saquinavir and ritonavir in human plasma by reversed-phase high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl., 1999, 727(1-2), 139-149.
[http://dx.doi.org/10.1016/S0378-4347(99)00079-1] [PMID: 10360433]
[http://dx.doi.org/10.1016/S0378-4347(99)00079-1] [PMID: 10360433]
[103]
Remmel, R.P.; Kawle, S.P.; Weller, D.; Fletcher, C.V. Simultaneous HPLC assay for quantification of indinavir, nelfinavir, ritonavir, and saquinavir in human plasma. Clin. Chem., 2000, 46(1), 73-81.
[http://dx.doi.org/10.1093/clinchem/46.1.73] [PMID: 10620574]
[http://dx.doi.org/10.1093/clinchem/46.1.73] [PMID: 10620574]
[104]
van Heeswijk, R.P.; Hoetelmans, R.M.; Harms, R.; Meenhorst, P.L.; Mulder, J.W.; Lange, J.M.; Beijnen, J.H. Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection. J. Chromatogr. B Biomed. Sci. Appl., 1998, 719(1-2), 159-168.
[http://dx.doi.org/10.1016/S0378-4347(98)00392-2] [PMID: 9869376]
[http://dx.doi.org/10.1016/S0378-4347(98)00392-2] [PMID: 9869376]
[105]
Sarasa-Nacenta, M.; López-Púa, Y.; Mallolas, J.; Blanco, J.L.; Gatell, J.M.; Carné, X. Simultaneous determination of the HIV-protease inhibitors indinavir, amprenavir, ritonavir, saquinavir and nelfinavir in human plasma by reversed-phase high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl., 2001, 757(2), 325-332.
[http://dx.doi.org/10.1016/S0378-4347(01)00172-4] [PMID: 11417878]
[http://dx.doi.org/10.1016/S0378-4347(01)00172-4] [PMID: 11417878]
[106]
Marzolini, C.; Telenti, A.; Buclin, T.; Biollaz, J.; Decosterd, L.A. Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir, nelfinavir and the non-nucleoside reverse transcriptase inhibitor efavirenz by high-performance liquid chromatography after solid-phase extraction. J. Chromatogr. B Biomed. Sci. Appl., 2000, 740(1), 43-58.
[http://dx.doi.org/10.1016/S0378-4347(99)00573-3] [PMID: 10798293]
[http://dx.doi.org/10.1016/S0378-4347(99)00573-3] [PMID: 10798293]
[107]
Verbesselt, R.; Van Wijngaerden, E.; de Hoon, J. Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 845(1), 51-60.
[http://dx.doi.org/10.1016/j.jchromb.2006.07.068] [PMID: 16997640]
[http://dx.doi.org/10.1016/j.jchromb.2006.07.068] [PMID: 16997640]
[108]
Hirabayashi, Y.; Tsuchiya, K.; Kimura, S.; Oka, S. Simultaneous determination of six HIV protease inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir), the active metabolite of nelfinavir (M8) and non-nucleoside reverse transcriptase inhibitor (efavirenz) in human plasma by high-performance liquid chromatography. Biomed. Chromatogr., 2006, 20(1), 28-36.
[http://dx.doi.org/10.1002/bmc.521] [PMID: 15971289]
[http://dx.doi.org/10.1002/bmc.521] [PMID: 15971289]
[109]
Takahashi, M.; Yoshida, M.; Oki, T.; Okumura, N.; Suzuki, T.; Kaneda, T. Conventional HPLC method used for simultaneous determination of the seven HIV protease inhibitors and nonnucleoside reverse transcription inhibitor efavirenz in human plasma. Biol. Pharm. Bull., 2005, 28(7), 1286-1290.
[http://dx.doi.org/10.1248/bpb.28.1286] [PMID: 15997115]
[http://dx.doi.org/10.1248/bpb.28.1286] [PMID: 15997115]
[110]
Droste, J.A.; Verweij-Van Wissen, C.P.; Burger, D.M. Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography. Ther. Drug Monit., 2003, 25(3), 393-399.
[http://dx.doi.org/10.1097/00007691-200306000-00023] [PMID: 12766571]
[http://dx.doi.org/10.1097/00007691-200306000-00023] [PMID: 12766571]
[111]
Titier, K.; Lagrange, F.; Péhourcq, F.; Edno-Mcheik, L.; Moore, N.; Molimard, M. High-performance liquid chromatographic method for the simultaneous determination of the six HIV-protease inhibitors and two non-nucleoside reverse transcriptase inhibitors in human plasma. Ther. Drug Monit., 2002, 24(3), 417-424.
[http://dx.doi.org/10.1097/00007691-200206000-00015] [PMID: 12021635]
[http://dx.doi.org/10.1097/00007691-200206000-00015] [PMID: 12021635]
[112]
Keil, K.; Frerichs, V.A.; DiFrancesco, R.; Morse, G. Reverse phase high-performance liquid chromatography method for the analysis of amprenavir, efavirenz, indinavir, lopinavir, nelfinavir and its active metabolite (M8), ritonavir, and saquinavir in heparinized human plasma. Ther. Drug Monit., 2003, 25(3), 340-346.
[http://dx.doi.org/10.1097/00007691-200306000-00015] [PMID: 12766563]
[http://dx.doi.org/10.1097/00007691-200306000-00015] [PMID: 12766563]
[113]
Charbe, N.; Baldelli, S.; Cozzi, V.; Castoldi, S.; Cattaneo, D.; Clementi, E. Development of an HPLC-UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients. J. Pharm. Anal., 2016, 6(6), 396-403.
[http://dx.doi.org/10.1016/j.jpha.2016.05.008] [PMID: 29404009]
[http://dx.doi.org/10.1016/j.jpha.2016.05.008] [PMID: 29404009]
[114]
Choi, S.O.; Rezk, N.L.; Kashuba, A.D. High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications. J. Pharm. Biomed. Anal., 2007, 43(4), 1562-1567.
[http://dx.doi.org/10.1016/j.jpba.2006.11.017] [PMID: 17236737]
[http://dx.doi.org/10.1016/j.jpba.2006.11.017] [PMID: 17236737]
[115]
Poirier, J.M.; Robidou, P.; Jaillon, P. Simple and simultaneous determination of the hiv-protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir plus M8 nelfinavir metabolite and the nonnucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma by reversed-phase liquid chromatography. Ther. Drug Monit., 2005, 27(2), 186-192.
[http://dx.doi.org/10.1097/01.ftd.0000152680.36517.5d] [PMID: 15795650]
[http://dx.doi.org/10.1097/01.ftd.0000152680.36517.5d] [PMID: 15795650]
[116]
Aymard, G.; Legrand, M.; Trichereau, N.; Diquet, B. Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl., 2000, 744(2), 227-240.
[http://dx.doi.org/10.1016/S0378-4347(00)00225-5] [PMID: 10993510]
[http://dx.doi.org/10.1016/S0378-4347(00)00225-5] [PMID: 10993510]
[117]
D’Avolio, A.; Baietto, L.; Siccardi, M.; Sciandra, M.; Simiele, M.; Oddone, V.; Bonora, S.; Di Perri, G. An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients. Ther. Drug Monit., 2008, 30(6), 662-669.
[http://dx.doi.org/10.1097/FTD.0b013e318189596d] [PMID: 18824956]
[http://dx.doi.org/10.1097/FTD.0b013e318189596d] [PMID: 18824956]
[118]
Checa, A.; Oliver, R.; Hernández-Cassou, S.; Saurina, J. Reversed-phase liquid chromatographic method with spectrophotometric detection for the determination of antiretroviral drugs. Anal. Chim. Acta, 2008, 616(1), 85-94.
[http://dx.doi.org/10.1016/j.aca.2008.04.026] [PMID: 18471488]
[http://dx.doi.org/10.1016/j.aca.2008.04.026] [PMID: 18471488]
[119]
Notari, S.; Bocedi, A.; Ippolito, G.; Narciso, P.; Pucillo, L.P.; Tossini, G.; Donnorso, R.P.; Gasparrini, F.; Ascenzi, P. Simultaneous determination of 16 anti-HIV drugs in human plasma by high-performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2006, 831(1-2), 258-266.
[http://dx.doi.org/10.1016/j.jchromb.2005.12.016] [PMID: 16406832]
[http://dx.doi.org/10.1016/j.jchromb.2005.12.016] [PMID: 16406832]
[120]
Koppala, S.; Panigrahi, B.; Raju, S.V.; Padmaja Reddy, K.; Ranga Reddy, V.; Anireddy, J.S. Development and validation of a simple, sensitive, selective and stability-indicating RP-UPLC method for the quantitative determination of ritonavir and its related compounds. J. Chromatogr. Sci., 2015, 53(5), 662-675.
[http://dx.doi.org/10.1093/chromsci/bmu097] [PMID: 25186277]
[http://dx.doi.org/10.1093/chromsci/bmu097] [PMID: 25186277]
[121]
Killi, G.D.; Maddinapudi, R.K.; Dinakaran, S.K.; Harani, A. A novel validated UPLC method for quantitation of lopinavir and ritonavir in bulk drug and pharmaceutical formulation with its impurities. Braz. J. Pharm. Sci., 2014, 50(2), 301-308.
[http://dx.doi.org/10.1590/S1984-82502014000200009]
[http://dx.doi.org/10.1590/S1984-82502014000200009]
[122]
Ocque, A.J.; Hagler, C.E.; Difrancesco, R.; Woolwine-Cunningham, Y.; Bednasz, C.J.; Morse, G.D.; Talal, A.H. Development and validation of a UPLC-MS/MS method for the simultaneous determination of paritaprevir and ritonavir in rat liver. Bioanalysis, 2016, 8(13), 1353-1363.
[http://dx.doi.org/10.4155/bio-2016-0040] [PMID: 27277877]
[http://dx.doi.org/10.4155/bio-2016-0040] [PMID: 27277877]
[123]
Yadav, M.; Rao, R.; Kurani, H.; Singhal, P.; Goswami, S.; Shrivastav, P.S. Application of a rapid and selective method for the simultaneous determination of protease inhibitors, lopinavir and ritonavir in human plasma by UPLC-ESI-MS/MS for bioequivalence study in Indian subjects. J. Pharm. Biomed. Anal., 2009, 49(4), 1115-1122.
[http://dx.doi.org/10.1016/j.jpba.2009.02.010] [PMID: 19282124]
[http://dx.doi.org/10.1016/j.jpba.2009.02.010] [PMID: 19282124]
[124]
Mishra, T.; Shrivastav, P.S. Validation of simultaneous quantitative method of HIV protease inhibitors atazanavir, darunavir and ritonavir in human plasma by UPLC-MS/MS. ScientificWorldJournal, 2014, 2014, 482693.
[http://dx.doi.org/10.1155/2014/482693] [PMID: 24587725]
[http://dx.doi.org/10.1155/2014/482693] [PMID: 24587725]
[125]
Das Mishra, T.; Kurani, H.; Singhal, P.; Shrivastav, P.S. Simultaneous quantitation of HIV-protease inhibitors ritonavir, lopinavir and indinavir in human plasma by UPLC-ESI-MS-MS. J. Chromatogr. Sci., 2012, 50(7), 625-635.
[http://dx.doi.org/10.1093/chromsci/bms048] [PMID: 22562821]
[http://dx.doi.org/10.1093/chromsci/bms048] [PMID: 22562821]
[126]
Huang, J.; Gautam, N.; Bathena, S.P.; Roy, U.; McMillan, J.; Gendelman, H.E.; Alnouti, Y. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2011, 879(23), 2332-2338.
[http://dx.doi.org/10.1016/j.jchromb.2011.06.032] [PMID: 21752731]
[http://dx.doi.org/10.1016/j.jchromb.2011.06.032] [PMID: 21752731]
[127]
Elens, L.; Veriter, S.; Di Fazio, V.; Vanbinst, R.; Boesmans, D.; Wallemacq, P.; Haufroid, V. Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection. Clin. Chem., 2009, 55(1), 170-174.
[http://dx.doi.org/10.1373/clinchem.2008.108647] [PMID: 19028822]
[http://dx.doi.org/10.1373/clinchem.2008.108647] [PMID: 19028822]
[128]
Yao, L.; Dou, W.Y.; Ma, Y.F.; Liu, Y.S. Development and validation of sensitive methods for simultaneous determination of 9 antiviral drugs in different various environmental matrices by UPLC-MS/MS. Chemosphere, 2021, 282, 131047.
[http://dx.doi.org/10.1016/j.chemosphere.2021.131047] [PMID: 34091295]
[http://dx.doi.org/10.1016/j.chemosphere.2021.131047] [PMID: 34091295]
[129]
Li, W.; Doherty, J.; Favara, S.; Breen, C.; Flarakos, J.; Tse, F.L. Evaluation of plasma microsampling for dried plasma spots (DPS) in quantitative LC-MS/MS bioanalysis using ritonavir as a model compound. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2015, 991, 46-52.
[http://dx.doi.org/10.1016/j.jchromb.2015.03.026] [PMID: 25913423]
[http://dx.doi.org/10.1016/j.jchromb.2015.03.026] [PMID: 25913423]
[130]
Patel, A.; Patel, A.; Makwana, A. An ESI-LC-MS/MS method for simultaneous estimation of darunavir and ritonavir in human plasma. Int. J. Res. Pharm. Biomed. Sci., 2013, 4(4), 1138-1147.
[131]
Burugula, L.; Pilli, N.R.; Makula, A.; Srinivas, D. Simultaneous determination of ritonavir and atazanavir in human plasma by LC-MS/MS and its pharmacokinetic application. Am. J. PharmTech Res., 2012, 2(4), 559-571.
[132]
Rao, R.N.; Prasad, K.G.; Kumar, K.S.; Ramesh, B. Diatomaceous earth supported liquid extraction and LC-MS/MS determination of elvitegravir and ritonavir in rat plasma: application to a pharmacokinetic study. Anal. Methods, 2014, 5(23), 6693-6699.
[http://dx.doi.org/10.1039/c3ay41346b]
[http://dx.doi.org/10.1039/c3ay41346b]
[133]
Farouk, F.; Wahba, D.; Mogawer, S.; Elkholy, S.; Elmeligui, A.; Abdelghani, R.; Ibahim, S. Development and validation of a new LC–MS/MS analytical method for direct-acting antivirals and its application in end-stage renal disease patients. Eur. J. Drug Metab. Pharmacokinet., 2020, 45(1), 89-99.
[http://dx.doi.org/10.1007/s13318-019-00584-6] [PMID: 31667795]
[http://dx.doi.org/10.1007/s13318-019-00584-6] [PMID: 31667795]
[134]
Hendrikx, J.J.; Rosing, H.; Schinkel, A.H.; Schellens, J.H.; Beijnen, J.H. Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS. Biomed. Chromatogr., 2014, 28(2), 302-310.
[http://dx.doi.org/10.1002/bmc.3021] [PMID: 23996474]
[http://dx.doi.org/10.1002/bmc.3021] [PMID: 23996474]
[135]
Rezk, N.L.; White, N.R.; Jennings, S.H.; Kashuba, A.D. A novel LC-ESI-MS method for the simultaneous determination of etravirine, darunavir and ritonavir in human blood plasma. Talanta, 2009, 79(5), 1372-1378.
[http://dx.doi.org/10.1016/j.talanta.2009.06.005] [PMID: 19635373]
[http://dx.doi.org/10.1016/j.talanta.2009.06.005] [PMID: 19635373]
[136]
Jaiswal, S.; Sharma, A.; Shukla, M.; Lal, J. Simultaneous LC-MS-MS determination of lopinavir and rifabutin in human plasma. J. Chromatogr. Sci., 2017, 55(6), 617-624.
[http://dx.doi.org/10.1093/chromsci/bmx016] [PMID: 28334925]
[http://dx.doi.org/10.1093/chromsci/bmx016] [PMID: 28334925]
[137]
Ehrhardt, M.; Möck, M.; Haefeli, W.E.; Mikus, G.; Burhenne, J. Monitoring of lopinavir and ritonavir in peripheral blood mononuclear cells, plasma, and ultrafiltrate using a selective and highly sensitive LC/MS/MS assay. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 850(1-2), 249-258.
[http://dx.doi.org/10.1016/j.jchromb.2006.11.037] [PMID: 17161668]
[http://dx.doi.org/10.1016/j.jchromb.2006.11.037] [PMID: 17161668]
[138]
Rajput, A.P.; Edlabadkar, A.P. An inclusive review on analytical methods for ritonavir in various pharmaceutical and biological matrix. Pharm. Methods, 2017, 8(2), 149-159.
[http://dx.doi.org/10.5530/phm.2017.8.23]
[http://dx.doi.org/10.5530/phm.2017.8.23]
[139]
Temghare, G.A.; Shetye, S.S.; Joshi, S.S. Rapid and sensitive method for quantitative determination of lopinavir and ritonavir in human plasma by liquid chromatography-tandem mass specrtometry. E-J. Chem., 2009, 6(1), 223-230.
[http://dx.doi.org/10.1155/2009/709478]
[http://dx.doi.org/10.1155/2009/709478]
[140]
Myasein, F.; Kim, E.; Zhang, J.; Wu, H.; El-Shourbagy, T.A. Rapid, simultaneous determination of lopinavir and ritonavir in human plasma by stacking protein precipitations and salting-out assisted liquid/liquid extraction, and ultrafast LC-MS/MS. Anal. Chim. Acta, 2009, 651(1), 112-116.
[http://dx.doi.org/10.1016/j.aca.2009.08.010] [PMID: 19733744]
[http://dx.doi.org/10.1016/j.aca.2009.08.010] [PMID: 19733744]
[141]
Estrela, R.C.; Ribeiro, F.S.; Seixas, B.V.; Suarez-Kurtz, G. Determination of lopinavir and ritonavir in blood plasma, seminal plasma, saliva and plasma ultra-filtrate by liquid chromatography/tandem mass spectrometry detection. Rapid Commun. Mass Spectrom., 2008, 22(5), 657-664.
[http://dx.doi.org/10.1002/rcm.3411] [PMID: 18257112]
[http://dx.doi.org/10.1002/rcm.3411] [PMID: 18257112]
[142]
Yao, Y.M.; Sun, J.J.; Chen, J.; Liu, X.Q.; Lu, H.Z.; Zhang, L.J. [LC-MS/MS method for simultaneous quantification of lopinavir and ritonavir in human plasma Yao Xue Xue Bao, 2010, 45(2), 279-282.
[PMID: 21351441]
[PMID: 21351441]
[143]
Shi, M.; Jian, L.I.; Gan, H.; Zheng, Y.; Meng, Z.; Dou, G. Development of LC-MS/MS method for rapid quantification of lopinavir/ ritonavir (Kaletra) in human plasma. J. Int. Pharmaceut. Res., 2016, (1), 162-166.
[144]
Damaramadugu, R.; Inamadugu, J.; Kanneti, R.; Polagani, S.; Ponneri, V. Simultaneous determination of ritonavir and lopinavir in human plasma after protein precipitation and LC-MS-MS. Chromatographia, 2010, 71(9), 815-824.
[http://dx.doi.org/10.1365/s10337-010-1550-9]
[http://dx.doi.org/10.1365/s10337-010-1550-9]
[145]
Huang, Y.; Gandhi, M.; Greenblatt, R.M.; Gee, W.; Lin, E.T.; Messenkoff, N. Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry. Rapid Commun. Mass Spectrom., 2008, 22(21), 3401-3409.
[http://dx.doi.org/10.1002/rcm.3750] [PMID: 18837069]
[http://dx.doi.org/10.1002/rcm.3750] [PMID: 18837069]
[146]
Koehn, J.; Ho, R.J. Novel liquid chromatography-tandem mass spectrometry method for simultaneous detection of anti-HIV drugs Lopinavir, Ritonavir, and Tenofovir in plasma. Antimicrob. Agents Chemother., 2014, 58(5), 2675-2680.
[http://dx.doi.org/10.1128/AAC.02748-13] [PMID: 24566184]
[http://dx.doi.org/10.1128/AAC.02748-13] [PMID: 24566184]
[147]
Notari, S.; Sergi, M.; Montesano, C.; Ivanovic, J.; Narciso, P.; Pucillo, L.P.; Ascenzi, P. Simultaneous determination of lamivudine, lopinavir, ritonavir, and zidovudine concentration in plasma of HIV-infected patients by HPLC-MS/MS. IUBMB Life, 2012, 64(5), 443-449.
[http://dx.doi.org/10.1002/iub.1025] [PMID: 22473795]
[http://dx.doi.org/10.1002/iub.1025] [PMID: 22473795]
[148]
Rouzes, A.; Berthoin, K.; Xuereb, F.; Djabarouti, S.; Pellegrin, I.; Pellegrin, J.L.; Coupet, A.C.; Augagneur, S.; Budzinski, H.; Saux, M.C.; Breilh, D. Simultaneous determination of the antiretroviral agents: amprenavir, lopinavir, ritonavir, saquinavir and efavirenz in human peripheral blood mononuclear cells by high-performance liquid chromatography-mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2004, 813(1-2), 209-216.
[http://dx.doi.org/10.1016/j.jchromb.2004.09.041] [PMID: 15556535]
[http://dx.doi.org/10.1016/j.jchromb.2004.09.041] [PMID: 15556535]
[149]
Mwando, E.; Massele, A.; Sepako, E.; Sichilongo, K. A method employing SPE, MRM LC-MS/MS and a THF–water solvent system for the simultaneous determination of five antiretroviral drugs in human blood plasma. Anal. Methods, 2017, 9(3), 450-458.
[http://dx.doi.org/10.1039/C6AY02442D]
[http://dx.doi.org/10.1039/C6AY02442D]
[150]
Chi, J.; Jayewardene, A.L.; Stone, J.A.; Motoya, T.; Aweeka, F.T. Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MS. J. Pharm. Biomed. Anal., 2002, 30(3), 675-684.
[http://dx.doi.org/10.1016/S0731-7085(02)00357-6] [PMID: 12367693]
[http://dx.doi.org/10.1016/S0731-7085(02)00357-6] [PMID: 12367693]
[151]
Zhang, L.J.; Yao, Y.M.; Sun, J.J.; Chen, J.; Jia, X.F. An LC–MS/MS method for simultaneous quantification of seven anti-HIV medicines in plasma of HIV-infected patients. Pharm. Anal. Acta, 2010, 1(1), 1-6.
[http://dx.doi.org/10.4172/2153-2435.1000102]
[http://dx.doi.org/10.4172/2153-2435.1000102]
[152]
Dickinson, L.; Robinson, L.; Tjia, J.; Khoo, S.; Back, D. Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2005, 829(1-2), 82-90.
[http://dx.doi.org/10.1016/j.jchromb.2005.09.032] [PMID: 16226495]
[http://dx.doi.org/10.1016/j.jchromb.2005.09.032] [PMID: 16226495]
[153]
Quaranta, S.; Woloch, C.; Paccou, A.; Giocanti, M.; Solas, C.; Lacarelle, B. Validation of an electrospray ionization LC-MS/MS method for quantitative analysis of raltegravir, etravirine, and 9 other antiretroviral agents in human plasma samples. Ther. Drug Monit., 2009, 31(6), 695-702.
[http://dx.doi.org/10.1097/FTD.0b013e3181c05adf] [PMID: 19865000]
[http://dx.doi.org/10.1097/FTD.0b013e3181c05adf] [PMID: 19865000]
[154]
Colombo, S.; Beguin, A.; Telenti, A.; Biollaz, J.; Buclin, T.; Rochat, B.; Decosterd, L.A. Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2005, 819(2), 259-276.
[http://dx.doi.org/10.1016/j.jchromb.2005.02.010] [PMID: 15833290]
[http://dx.doi.org/10.1016/j.jchromb.2005.02.010] [PMID: 15833290]
[155]
D’Avolio, A.; Siccardi, M.; Sciandra, M.; Baietto, L.; Bonora, S.; Trentini, L.; Di Perri, G. HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2007, 859(2), 234-240.
[http://dx.doi.org/10.1016/j.jchromb.2007.10.003] [PMID: 17964231]
[http://dx.doi.org/10.1016/j.jchromb.2007.10.003] [PMID: 17964231]
[156]
Koal, T.; Burhenne, H.; Römling, R.; Svoboda, M.; Resch, K.; Kaever, V. Quantification of antiretroviral drugs in dried blood spot samples by means of liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom., 2005, 19(21), 2995-3001.
[http://dx.doi.org/10.1002/rcm.2158] [PMID: 16193530]
[http://dx.doi.org/10.1002/rcm.2158] [PMID: 16193530]
[157]
Koal, T.; Sibum, M.; Koster, E.; Resch, K.; Kaever, V. Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma. Clin. Chem. Lab. Med., 2006, 44(3), 299-305 [CCLM].
[http://dx.doi.org/10.1515/CCLM.2006.052] [PMID: 16519602]
[http://dx.doi.org/10.1515/CCLM.2006.052] [PMID: 16519602]
[158]
Alffenaar, J.W. Development and validation of a bioanalytical method for the simultaneous determination of 14 antiretroviral drugs using liquid chromatography-tandem mass spectrometry. J. Appl. Bioanal., 2018, 4(2), 37-50.
[http://dx.doi.org/10.17145/jab.18.007]
[http://dx.doi.org/10.17145/jab.18.007]
[159]
ter Heine, R.; Rosing, H.; van Gorp, E.C.; Mulder, J.W.; van der Steeg, W.A.; Beijnen, J.H.; Huitema, A.D. Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2008, 867(2), 205-212.
[http://dx.doi.org/10.1016/j.jchromb.2008.04.003] [PMID: 18456582]
[http://dx.doi.org/10.1016/j.jchromb.2008.04.003] [PMID: 18456582]
[160]
Jung, B.H.; Rezk, N.L.; Bridges, A.S.; Corbett, A.H.; Kashuba, A.D. Simultaneous determination of 17 antiretroviral drugs in human plasma for quantitative analysis with liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr., 2007, 21(10), 1095-1104.
[http://dx.doi.org/10.1002/bmc.865] [PMID: 17582235]
[http://dx.doi.org/10.1002/bmc.865] [PMID: 17582235]
[161]
Habler, K.; Brügel, M.; Teupser, D.; Liebchen, U.; Scharf, C.; Schönermarck, U.; Vogeser, M.; Paal, M. Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC-MS/MS method in human serum. J. Pharm. Biomed. Anal., 2021, 196, 113935.
[http://dx.doi.org/10.1016/j.jpba.2021.113935] [PMID: 33548872]
[http://dx.doi.org/10.1016/j.jpba.2021.113935] [PMID: 33548872]
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