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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

Neural Substrates for the Regulation of Sleep and General Anesthesia

Author(s): Qianzi Yang, Fang Zhou, Ao Li and Hailong Dong*

Volume 20, Issue 1, 2022

Page: [72 - 84] Pages: 13

DOI: 10.2174/1570159X19666211214144639

Price: $65

Abstract

General anesthesia has been successfully used in clinics for over 170 years, but its mechanisms of effect remain unclear. Behaviorally, general anesthesia is similar to sleep as it produces a reversible transition between wakefulness and the state of being unaware of one’s surroundings. A discussion regarding the common circuits of sleep and general anesthesia has been ongoing as an increasing number of sleep-arousal regulatory nuclei are reported to participate in the consciousness shift occurring during general anesthesia. Recently, with progress in research technology, both positive and negative evidence for overlapping neural circuits between sleep and general anesthesia has emerged. This article provides a review of the latest evidence on the neural substrates for sleep and general anesthesia regulation by comparing the roles of pivotal nuclei in sleep and anesthesia.

Keywords: Sleep, anesthesia, neural circuits, wakefulness, unconsciousness, sleep-arousal regulatory nuclei.

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