Neuroinflammation in Huntington’s Disease: A Starring Role for Astrocyte
and Microglia

Julieta       Saba; Federico    López    Couselo; Julieta       Bruno; Lila       Carniglia; Daniela       Durand; Mercedes       Lasaga; Carla       Caruso
doi:10.2174/1570159X19666211201094608
Abstract

Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction. Since no existing treatment affects the course of this disease, new treatments are needed. Inflammation is frequently observed in HD patients before symptom onset. Neuroinflammation, characterized by the presence of reactive microglia, astrocytes and inflammatory factors within the brain, is also detected early. However, in comparison to other neurodegenerative diseases, the role of neuroinflammation in HD is much less known. Work has been dedicated to altered microglial and astrocytic functions in the context of HD, but less attention has been given to glial participation in neuroinflammation. This review describes evidence of inflammation in HD patients and animal models. It also discusses recent knowledge on neuroinflammation in HD, highlighting astrocyte and microglia involvement in the disease and considering anti-inflammatory therapeutic approaches.
Keywords: Huntington’s disease, mutant huntingtin, neuroinflammation, astrocytes, microglia, neurodegeneration.
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DOI https://dx.doi.org/10.2174/1570159X19666211201094608	Print ISSN 1570-159X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6190
Current Neuropharmacology

Neuroinflammation in Huntington’s Disease: A Starring Role for Astrocyte and Microglia

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