Medicinal Chemistry Strategies Towards SO₂ Donors as Research Tools and Potential Therapeutics

Title:Medicinal Chemistry Strategies Towards SO₂ Donors as Research Tools and Potential Therapeutics

Volume: 21 Issue: 32

Author(s): Eman M El-Labbad*, Xingyue Ji*, Khaled A.M. Abouzid and Binghe Wang

Affiliation:

• Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566, Cairo,Egypt

• Department of Medicinal Chemistry, College of Pharmaceutical Science, Soochow University, 215123, Suzhou,China

Keywords: Sulfur dioxide, Prodrugs, Drug delivery, Gasotransmitter, Donors, Click and release.

Abstract: SO₂ is emerging as a possible endogenous signaling molecule in mammals. In addition, SO₂ has also shown pharmacological effects, presenting SO₂ as a promising potential therapeutic agent. The past decade has witnessed steady advances in the development of small molecule-based SO₂ prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed for SO₂ prodrug design. The remaining challenges and issues will also be discussed.

Cite this article as:

El-Labbad M Eman *, Ji Xingyue *, Abouzid A.M. Khaled and Wang Binghe , Medicinal Chemistry Strategies Towards SO₂ Donors as Research Tools and Potential Therapeutics, Current Topics in Medicinal Chemistry 2021; 21 (32) . https://dx.doi.org/10.2174/1568026621666211116091354