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Letters in Organic Chemistry

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Letter Article

Water-Mediated Green Synthesis of Benzimidazoles Using Pyruvic Acid: A Comparable Study of Ultra-sonication versus Conventional Heating

Author(s): Santosh Rangnath Deshmukh*, Archana Subhash Nalkar and Shankar Ramchandra Thopate

Volume 19, Issue 7, 2022

Published on: 11 January, 2022

Page: [511 - 519] Pages: 9

DOI: 10.2174/1570178618666211105092142

Price: $65

Abstract

An efficient and green protocol has been introduced for the synthesis of benzimidazole derivatives using a pyruvic acid catalyst in the presence of water. Pyruvic acid catalyses the reaction of aromatic aldehydes with o-phenylenediamine efficiently, and products were obtained in good to excellent yields under sonication (50 °C) or under conventional heating (50 °C). The advantages of this synthetic methodology are the use of eco-friendly, commercially cheap, biodegradable catalyst, metal-free and Lewis acid-free mild reaction conditions with excellent yields, short reaction times, and compatible with a wide range of electronically diverse substrates. Pyruvic acid in water as a catalyst under ultrasound irradiation can be a better alternative to synthesize benzimidazole derivatives than some of the traditional methods.

Keywords: Pyruvic acid, benzimidazole, aldehyde, o-phenylenediamine, ultrasound irradiation, green chemistry, heterocyclic chemistry.

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