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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

非铜蓝蛋白铜作为阿尔茨海默病患者的分层生物标志物：如何测量和使用它

卷 18, 期 7, 2021

发表于: 21 October, 2021

页: [533 - 545] 页: 13

弟呕挨: 10.2174/1567205018666211022085755

价格: $65

摘要

阿尔茨海默病 (AD) 是一种在老年人中非常常见的痴呆症。最近越来越多的证据将 AD 发病机制与体内铜 (Cu) 代谢障碍联系起来。事实上，已经观察到一部分受 AD 或其前驱症状（称为轻度认知障碍 (MCI)）影响的患者无法维持铜代谢和分布的适当平衡，其特征是在他们的血清中存在不与铜蓝蛋白结合的铜水平增加（非铜蓝蛋白铜）。由于血清非铜蓝蛋白铜是威尔逊病 (WD) 的生物标志物，这是一种众所周知的铜驱动中毒病症，在本综述中，我们建议与 WD 非常相似，非铜蓝蛋白铜水平的评估可以被用作一种具有成本效益的分层和易感性/风险生物标志物，用于识别某些 AD/MCI 个体。该方法还可用作旨在研究铜相关干预措施对抗 AD/MCI 的临床试验的资格标准。

关键词: 阿尔茨海默病、铜、非铜蓝蛋白铜、铜蓝蛋白、锌、生物标志物、分层、风险/易感性。

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