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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Case Report

Domperidone Withdrawal in a Nursing Female with Pre-existing Psychiatric Illness: A Case Report

Author(s): Verinder Sharma*, Sapna Sharma and Minakshi Doobay

Volume 17, Issue 3, 2022

Published on: 14 January, 2022

Page: [278 - 280] Pages: 3

DOI: 10.2174/1574886316666211013120735

Price: $65

Abstract

Background: In this report, we describe a case of domperidone withdrawal in a woman with a history of major depressive disorder and obsessive-compulsive disorder (OCD), who experienced a recurrence of these disorders after stopping domperidone.

Case Presentation: The symptoms improved after the restarting of domperidone and disappeared gradually as the drug was tapered and discontinued. Clinicians should consider domperidone withdrawal a differential diagnosis in women with a history of depression or anxiety who present with an acute onset of these symptoms following the abrupt discontinuation of domperidone.

Conclusion: A gradual taper off of the drug may be effective in minimizing withdrawal symptoms and obviate the need for psychotropic drug use.

Keywords: Domperidone, lactation, withdrawal-induced, depression, OCD, galactagogue.

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Graphical Abstract

[1]
U.S. Food & Drug Administration. FDA Talk Paper: FDA Warns Against Women Using Unapproved Drug, Domperidone, to Increase Milk Production | FDA. 2004. Available from: https://www.fda.gov/drugs/information-drug-class/fda-talk-paper-fda-warns-against-women-using-unapproved-drug-domperidone-increase-milk-production [Cited 2021 Jan 15]
[2]
Smolina K, Morgan SG, Hanley GE, Oberlander TF, Mintzes B. Postpartum domperidone use in British Columbia: a retrospective cohort study. C Open 2016; 4(1): E13-9. Available from: /pmc/articles/PMC4866923/?report=abstract [Cited 2021 Jan 15]
[3]
Paul C, Zénut M, Dorut A, et al. Use of domperidone as a galactagogue drug: A systematic review of the benefit-risk ratio. J Hum Lact 2015; 31(1): 57-63. Available from: https://pubmed.ncbi.nlm.nih.gov/25475074/ [Cited 2021 Jan 15]
[4]
Hondeghem LM, Logghe NH. Should domperidone be used as a galactagogue? possible safety implications for mother and child. Drug Saf 2017; 40(2): 109-13. Available from: https://pubmed.ncbi.nlm.nih.gov/27900667/ [Cited 2021 Jan 15]
[http://dx.doi.org/10.1007/s40264-016-0478-x]
[5]
Doyle M, Grossman M. Case report: domperidone use as a galactagogue resulting in withdrawal symptoms upon discontinuation. Arch Womens Ment Health 2018; 21(4): 461-3. Available from: https://pubmed.ncbi.nlm.nih.gov/29090362/ [Cited 2021 Jan 15]
[http://dx.doi.org/10.1007/s00737-017-0796-8]
[6]
Papastergiou J, Abdallah M, Tran A, Folkins C. Domperidone withdrawal in a breastfeeding woman. Can Pharm J 2013; 146(4): 210-2. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734912/ [Cited 2021 Jan 15]
[http://dx.doi.org/10.1177/1715163513492928]
[7]
Seeman P. Yes, breast is best, but taper domperidone when stopping. Brit J Gen Prac 2014. Available from: https://bjgp.org/content/yes-breast-best-taper-domperidone-when-stopping [Cited 2021 Jan 15]
[8]
Sharma V. Weaning and mixed mania—a case report. J Hum Lact 2018; 34(4): 745-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29928823 [Cited 2018 Sep 10]
[9]
Park K, Jaekal E, Yoon S, Lee SH, Choi KH. Diagnostic utility and psychometric properties of the beck depression inventory-ii among korean adults. Front Psychol 2020; 10: 2934. Available from: https://pubmed.ncbi.nlm.nih.gov/32038360/ [Cited 2021 Jan 15]
[http://dx.doi.org/10.3389/fpsyg.2019.02934]
[10]
Spitzer RL, Kroenke K, Williams JBW, Löwe B. A brief measure for assessing generalized anxiety disorder: The GAD-7. Arch Intern Med 2006; 166(10): 1092-7. Available from: https://pubmed.ncbi.nlm.nih.gov/16717171/ [Cited 2021 Jan 15]
[11]
Carvalho AF, Takwoingi Y, Sales PMG, Soczynska JK, Köhler CA, Freitas TH, et al. Screening for bipolar spectrum disorders: A comprehensive meta-analysis of accuracy studies. J Affect Disord 2015; 172: 337-46. Available from: https://pubmed.ncbi.nlm.nih.gov/25451435/ [Cited 2021 Jan 15]
[12]
Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington: American Psychiatric Association, 2013.
[13]
Sharma V. Role of sleep deprivation in the causation of postpartum obsessive-compulsive disorder. Med Hypotheses 2019; 122: 58-61.
[http://dx.doi.org/10.1016/j.mehy.2018.10.016] [PMID: 30593425]
[14]
Whitley J, Wouk K, Bauer AE, et al. Oxytocin during breastfeeding and maternal mood symptoms. Psychoneuroendocrinology 2020; 113: 104581.
[http://dx.doi.org/10.1016/j.psyneuen.2019.104581] [PMID: 31911347]

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