Systematic Review Methodologies and Endocrine Disrupting Chemicals:
Improving Evaluations of the Plastic Monomer Bisphenol A

Laura   N.   Vandenberg; Katherine   E.   Pelch
doi:10.2174/1871530321666211005163614
Abstract

Background: Endocrine disrupting chemicals (EDCs) are found in plastics, personal care products, household items, and other consumer goods. Risk assessments are intended to characterize a chemical’s hazards, identify the doses at which adverse outcomes are observed, quantify exposure levels, and then compare these doses to determine the likelihood of risk in a given population. There are many problems with risk assessments for EDCs, allowing people to be exposed to levels that are later associated with serious health outcomes in epidemiology studies.
Objective: In this review, we examine issues that affect the evaluation of EDCs in risk assessments (e.g., use of insensitive rodent strains and absence of disease-oriented outcomes in hazard assessments; inadequate exposure assessments). We then review one well-studied chemical, Bisphenol A (BPA; CAS #80-05-7) an EDC found in plastics, food packaging, and other consumer products. More than one hundred epidemiology studies suggest associations between BPA exposures and adverse health outcomes in environmentally exposed human populations.
Results: We present support for the use of systematic review methodologies in the evaluation of BPA and other EDCs. Systematic reviews would allow studies to be evaluated for their reliability and risk of bias. They would also allow all data to be used in risk assessments, which is a requirement for some regulatory agencies.
Conclusion: Systematic review methodologies can be used to improve evaluations of BPA and other EDCs. Their use could help to restore faith in risk assessments and ensure that all data are utilized in decision-making. Regulatory agencies are urged to conduct transparent, well-documented and proper systematic reviews for BPA and other EDCs.
Keywords: Meta-analysis, uterotrophic, key characteristic, low dose effect, klimisch score, xenoestrogen.
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Graphical Abstract

[1] 
Kavlock, R.J.; Daston, G.P.; DeRosa, C.; Fenner-Crisp, P.; Gray, L.E.; Kaattari, S.; Lucier, G.; Luster, M.; Mac, M.J.; Maczka, C.; Miller, R.; Moore, J.; Rolland, R.; Scott, G.; Sheehan, D.M.; Sinks, T.; Tilson, H.A. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: A report of the U.S. EPA-sponsored workshop. Environ. Health Perspect.,  1996, 104(Suppl. 4), 715-740.
[PMID: 8880000] 
[2] 
Zoeller, R.T.; Brown, T.R.; Doan, L.L.; Gore, A.C.; Skakkebaek, N.E.; Soto, A.M.; Woodruff, T.J.; Vom Saal, F.S. Endocrine-disrupting chemicals and public health protection: A statement of principles from The Endocrine Society. Endocrinology,  2012, 153(9), 4097-4110.
[http://dx.doi.org/10.1210/en.2012-1422] [PMID: 22733974] 
[3] 
Gore, A.C.; Chappell, V.A.; Fenton, S.E.; Flaws, J.A.; Nadal, A.; Prins, G.S.; Toppari, J.; Zoeller, R.T. EDC-2: The endocrine society’s second scientific statement on endocrine-disrupting chemicals. Endocr. Rev.,  2015, 36(6), E1-E150.
[http://dx.doi.org/10.1210/er.2015-1010] [PMID: 26544531] 
[4] 
FDA, U.S. Endocrine Disruptor Knowledge Base. 2012. August 20, 2012;  Available from: http://www.fda.gov/ScienceResearch/ BioinformaticsTools/EndocrineDisruptorKnowledgebase/default.htm
[5] 
Vandenberg, L.N.; Catanese, M.C. Casting a wide net for endocrine disruptors. Chem. Biol.,  2014, 21(6), 705-706.
[http://dx.doi.org/10.1016/j.chembiol.2014.06.002] [PMID: 24950102] 
[6] 
Heindel, J.J.; Blumberg, B.; Cave, M.; Machtinger, R.; Mantovani, A.; Mendez, M.A.; Nadal, A.; Palanza, P.; Panzica, G.; Sargis, R.; Vandenberg, L.N.; vom Saal, F. Metabolism disrupting chemicals and metabolic disorders. Reprod. Toxicol.,  2017, 68, 3-33.
[http://dx.doi.org/10.1016/j.reprotox.2016.10.001] [PMID: 27760374] 
[7] 
Vandenberg, L.N. Low-dose effects of hormones and endocrine disruptors. Vitam. Horm.,  2014, 94, 129-165.
[http://dx.doi.org/10.1016/B978-0-12-800095-3.00005-5] [PMID: 24388189] 
[8] 
Vandenberg, L.N.; Colborn, T.; Hayes, T.B.; Heindel, J.J.; Jacobs, D.R., Jr; Lee, D.H.; Shioda, T.; Soto, A.M.; vom Saal, F.S.; Welshons, W.V.; Zoeller, R.T.; Myers, J.P. Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses. Endocr. Rev.,  2012, 33(3), 378-455.
[http://dx.doi.org/10.1210/er.2011-1050] [PMID: 22419778] 
[9] 
Vandenberg, L.N.; Ehrlich, S.; Belcher, S.M.; Ben-Jonathan, N.; Dolinoy, D.C.; Hugo, E.R.; Hunt, P.A.; Newbold, R.R.; Rubin, B.S.; Saili, K.S.; Soto, A.M.; Wang, H-S.; vom Saal, F.S. Low dose effects of bisphenol A. Endocr. Disruptors (Austin),  2013, 1(1), e26490.
[http://dx.doi.org/10.4161/endo.26490] 
[10] 
Vandenberg, L.N.; Najmi, A.; Mogus, J.P. Agrochemicals with estrogenic endocrine disrupting properties: Lessons Learned? Mol. Cell. Endocrinol.,  2020, 518, 110860.
[http://dx.doi.org/10.1016/j.mce.2020.110860] [PMID: 32407980] 
[11] 
Vandenberg, L.N.; Bugos, J. Assessing the public health implications of the food preservative propylparaben: Has this chemical been safely used for decades. Curr. Environ. Health Rep.,  2021, 8(1), 54-70.
[http://dx.doi.org/10.1007/s40572-020-00300-6] [PMID: 33415721] 
[12] 
Caserta, D.; Costanzi, F.; De Marco, M.P.; Di Benedetto, L.; Matteucci, E.; Assorgi, C.; Pacilli, M.C.; Besharat, A.R.; Bellati, F.; Ruscito, I. Effects of endocrine-disrupting chemicals on endometrial receptivity and embryo implantation: A systematic review of 34 mouse model studies. Int. J. Environ. Res. Public Health,  2021, 18(13), 6840.
[http://dx.doi.org/10.3390/ijerph18136840] [PMID: 34202247] 
[13] 
Zhu, S.; Zhang, T.; Wang, Y.; Zhou, X.; Wang, S.; Wang, Z. Meta-analysis and experimental validation identified atrazine as a toxicant in the male reproductive system. Environ. Sci. Pollut. Res. Int.,  2021, 28(28), 37482-37497.
[http://dx.doi.org/10.1007/s11356-021-13396-6] [PMID: 33715114] 
[14] 
Hayes, T.B.; Anderson, L.L.; Beasley, V.R.; de Solla, S.R.; Iguchi, T.; Ingraham, H.; Kestemont, P.; Kniewald, J.; Kniewald, Z.; Langlois, V.S.; Luque, E.H.; McCoy, K.A.; Muñoz-de-Toro, M.; Oka, T.; Oliveira, C.A.; Orton, F.; Ruby, S.; Suzawa, M.; Tavera-Mendoza, L.E.; Trudeau, V.L.; Victor-Costa, A.B.; Willingham, E. Demasculinization and feminization of male gonads by atrazine: Consistent effects across vertebrate classes. J. Steroid Biochem. Mol. Biol.,  2011, 127(1-2), 64-73.
[http://dx.doi.org/10.1016/j.jsbmb.2011.03.015] [PMID: 21419222] 
[15] 
Zhang, T.; Zhou, X.; Xu, A.; Tian, Y.; Wang, Y.; Zhang, Y.; Gu, Q.; Wang, S.; Wang, Z. Toxicity of polybrominated diphenyl ethers (PBDEs) on rodent male reproductive system: A systematic review and meta-analysis of randomized control studies. Sci. Total Environ.,  2020, 720, 137419.
[http://dx.doi.org/10.1016/j.scitotenv.2020.137419] [PMID: 32325560] 
[16] 
Wang, Q.; Shen, J.Y.; Zhang, R.; Hong, J.W.; Li, Z.; Ding, Z.; Wang, H.X.; Zhang, J.P.; Zhang, M.R.; Xu, L.C. Effects and mechanisms of pyrethroids on male reproductive system. Toxicology,  2020, 438, 152460.
[http://dx.doi.org/10.1016/j.tox.2020.152460] [PMID: 32278050] 
[17] 
Patisaul, H.B.; Belcher, S.M. Endocrine disruptors, brain, and behavior; Oxford Univ. Press: Oxford, 2017. 
[http://dx.doi.org/10.1093/acprof:oso/9780199935734.001.0001] 
[18] 
Heindel, J.J. Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies. Reprod. Toxicol.,  2020, 98, 29-60.
[http://dx.doi.org/10.1016/j.reprotox.2020.05.014] 
[19] 
Walker, D.M.; Goetz, B.M.; Gore, A.C. Dynamic postnatal developmental and sex-specific neuroendocrine effects of prenatal polychlorinated biphenyls in rats. Mol. Endocrinol.,  2014, 28(1), 99-115.
[http://dx.doi.org/10.1210/me.2013-1270] [PMID: 24284824] 
[20] 
Gore, A.C.; Krishnan, K.; Reilly, M.P. Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior. Horm. Behav.,  2019, 111, 7-22.
[http://dx.doi.org/10.1016/j.yhbeh.2018.11.006] [PMID: 30476496] 
[21] 
Gore, A.C.; Holley, A.M.; Crews, D. Mate choice, sexual selection, and endocrine-disrupting chemicals. Horm. Behav.,  2018, 101, 3-12.
[http://dx.doi.org/10.1016/j.yhbeh.2017.09.001] [PMID: 28888817] 
[22] 
Rattan, S.; Zhou, C.; Chiang, C.; Mahalingam, S.; Brehm, E.; Flaws, J.A. Exposure to endocrine disruptors during adulthood: Consequences for female fertility. J. Endocrinol.,  2017, 233(3), R109-R129.
[http://dx.doi.org/10.1530/JOE-17-0023] [PMID: 28356401] 
[23] 
Patel, S.; Zhou, C.; Rattan, S.; Flaws, J.A. Effects of endocrine-disrupting chemicals on the ovary1. Biol. Reprod.,  2015, 93(1), 20.
[http://dx.doi.org/10.1095/biolreprod.115.130336] [PMID: 26063868] 
[24] 
Seachrist, D.D.; Bonk, K.W.; Ho, S.M.; Prins, G.S.; Soto, A.M.; Keri, R.A. A review of the carcinogenic potential of bisphenol A. Reprod. Toxicol.,  2016, 59, 167-182.
[http://dx.doi.org/10.1016/j.reprotox.2015.09.006] [PMID: 26493093] 
[25] 
Nadal, A.; Quesada, I.; Tudurí, E.; Nogueiras, R.; Alonso-Magdalena, P. Endocrine-disrupting chemicals and the regulation of energy balance. Nat. Rev. Endocrinol.,  2017, 13(9), 536-546.
[http://dx.doi.org/10.1038/nrendo.2017.51] [PMID: 28524168] 
[26] 
Bergman, Å. The State-of-the-Science of Endocrine Disrupting Chemicals – 2012. WHO (World Health Organization)/UNEP (United Nations Environment Programme). Vol; UNEP/WHO: Geneva, 2013.  Available from: http://www.who.int/ iris/bitstream/10665/78101/1/9789241505031_eng.pdf
[27] 
Stillerman, K.P.; Mattison, D.R.; Giudice, L.C.; Woodruff, T.J. Environmental exposures and adverse pregnancy outcomes: A review of the science. Reprod. Sci.,  2008, 15(7), 631-650.
[http://dx.doi.org/10.1177/1933719108322436] [PMID: 18836129] 
[28] 
Rochester, J.R. Bisphenol A and human health: A review of the literature. Reprod. Toxicol.,  2013, 42, 132-155.
[http://dx.doi.org/10.1016/j.reprotox.2013.08.008] [PMID: 23994667] 
[29] 
Crain, D.A.; Janssen, S.J.; Edwards, T.M.; Heindel, J.; Ho, S.; Hunt, P.; Iguchi, T.; Juul, A.; McLachlan, J.A.; Schwartz, J.; Skakkebaek, N.; Soto, A.M.; Swan, S.; Walker, C.; Woodruff, T.K.; Woodruff, T.J.; Giudice, L.C.; Guillette, L.J., Jr Female reproductive disorders: The roles of endocrine-disrupting compounds and developmental timing. Fertil. Steril.,  2008, 90(4), 911-940.
[http://dx.doi.org/10.1016/j.fertnstert.2008.08.067] [PMID: 18929049] 
[30] 
Skakkebaek, N.E.; Rajpert-De Meyts, E.; Buck Louis, G.M.; Toppari, J.; Andersson, A.M.; Eisenberg, M.L.; Jensen, T.K.; Jørgensen, N.; Swan, S.H.; Sapra, K.J.; Ziebe, S.; Priskorn, L.; Juul, A. Male reproductive disorders and fertility trends: Influences of environment and genetic susceptibility. Physiol. Rev.,  2016, 96(1), 55-97.
[http://dx.doi.org/10.1152/physrev.00017.2015] [PMID: 26582516] 
[31] 
Meeker, J.D.; Sathyanarayana, S.; Swan, S.H. Phthalates and other additives in plastics: Human exposure and associated health outcomes. Philos. Trans. R. Soc. Lond. B Biol. Sci.,  2009, 364(1526), 2097-2113.
[http://dx.doi.org/10.1098/rstb.2008.0268] [PMID: 19528058] 
[32] 
Kahn, L.G.; Trasande, L. Environmental toxicant exposure and hypertensive disorders of pregnancy: Recent findings. Curr. Hypertens. Rep.,  2018, 20(10), 87.
[http://dx.doi.org/10.1007/s11906-018-0888-5] [PMID: 30090982] 
[33] 
Trasande, L.; Shaffer, R.M.; Sathyanarayana, S. Food additives and child health. Pediatrics,  2018, 142(2), e20181408.
[http://dx.doi.org/10.1542/peds.2018-1408] [PMID: 30037974] 
[34] 
Maffini, M.V.; Trasande, L.; Neltner, T.G. Perchlorate and diet: Human exposures, risks, and mitigation strategies. Curr. Environ. Health Rep.,  2016, 3(2), 107-117.
[http://dx.doi.org/10.1007/s40572-016-0090-3] [PMID: 27029550] 
[35] 
Namat, A.; Xia, W.; Xiong, C.; Xu, S.; Wu, C.; Wang, A.; Li, Y.; Wu, Y.; Li, J. Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review. Ecotoxicol. Environ. Saf.,  2021, 220, 112400.
[http://dx.doi.org/10.1016/j.ecoenv.2021.112400] [PMID: 34116331] 
[36] 
Wan, M.L.Y.; Co, V.A.; El-Nezami, H. Endocrine disrupting chemicals and breast cancer: A systematic review of epidemiological studies. Crit. Rev. Food Sci. Nutr.,  2021, 5, 1-27.
[http://dx.doi.org/10.1080/10408398.2021.1903382] [PMID: 33819127] 
[37] 
Mendes, V.; Ribeiro, C.; Delgado, I.; Peleteiro, B.; Aggerbeck, M.; Distel, E.; Annesi-Maesano, I.; Sarigiannis, D.; Ramos, E. The association between environmental exposures to chlordanes, adiposity and diabetes-related features: A systematic review and meta-analysis. Sci. Rep.,  2021, 11(1), 14546.
[http://dx.doi.org/10.1038/s41598-021-93868-4] [PMID: 34267268] 
[38] 
Conforti, A.; Carbone, L.; Simeon, V.; Chiodini, P.; Marrone, V.; Bagnulo, F.; Cariati, F.; Strina, I.; Alviggi, C. Unravelling the link between phthalate exposure and endometriosis in humans: A systematic review and meta-analysis of the literature. J. Assist. Reprod. Genet.,  2021, 38(10), 2543-2557.
[http://dx.doi.org/10.1007/s10815-021-02265-3] [PMID: 34227050] 
[39] 
Rocha, P.R.S.; Oliveira, V.D.; Vasques, C.I.; dos Reis, P.E.D.; Amato, A.A. Exposure to endocrine disruptors and risk of breast cancer: A systematic review. Crit. Rev. Oncol. Hematol.,  2021, 161, 103330.
[http://dx.doi.org/10.1016/j.critrevonc.2021.103330] [PMID: 33862246] 
[40] 
Kahn, L.G.; Harley, K.G.; Siegel, E.L.; Zhu, Y.; Factor-Litvak, P.; Porucznik, C.A.; Klein-Fedyshin, M.; Hipwell, A.E. Persistent organic pollutants and couple fecundability: A systematic review. Hum. Reprod. Update,  2021, 27(2), 339-366.
[http://dx.doi.org/10.1093/humupd/dmaa037] [PMID: 33147335] 
[41] 
Fernández-Martínez, N.F.; Ching-López, A.; Olry de Labry Lima, A.; Salamanca-Fernández, E.; Pérez-Gómez, B.; Jiménez-Moleón, J.J.; Sánchez, M.J.; Rodríguez-Barranco, M. Relationship between exposure to mixtures of persistent, bioaccumulative, and toxic chemicals and cancer risk: A systematic review. Environ. Res.,  2020, 188, 109787.
[http://dx.doi.org/10.1016/j.envres.2020.109787] [PMID: 32798941] 
[42] 
Ribeiro, C.M.; Beserra, B.T.S.; Silva, N.G.; Lima, C.L.; Rocha, P.R.S.; Coelho, M.S.; Neves, F.A.R.; Amato, A.A. Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: A systematic review and meta-analysis. BMJ Open,  2020, 10(6), e033509.
[http://dx.doi.org/10.1136/bmjopen-2019-033509] [PMID: 32565448] 
[43] 
Fu, X.; Xu, J.; Zhang, R.; Yu, J. The association between environmental endocrine disruptors and cardiovascular diseases: A systematic review and meta-analysis. Environ. Res.,  2020, 187, 109464.
[http://dx.doi.org/10.1016/j.envres.2020.109464] [PMID: 32438096] 
[44] 
Bliatka, D.; Nigdelis, M.P.; Chatzimeletiou, K.; Mastorakos, G.; Lymperi, S.; Goulis, D.G. The effects of postnatal exposure of endocrine disruptors on testicular function: A systematic review and a meta-analysis. Hormones (Athens),  2020, 19(2), 157-169.
[http://dx.doi.org/10.1007/s42000-019-00170-0] [PMID: 31925736] 
[45] 
Nelson, W.; Liu, D.Y.; Yang, Y.; Zhong, Z.H.; Wang, Y.X.; Ding, Y. In utero exposure to persistent and nonpersistent endocrine-disrupting chemicals and anogenital distance. A systematic review of epidemiological studies†. Biol. Reprod.,  2020, 102(2), 276-291.
[http://dx.doi.org/10.1093/biolre/ioz200] [PMID: 31621835] 
[46] 
Rivollier, F.; Krebs, M.O.; Kebir, O. Perinatal exposure to environmental endocrine disruptors in the emergence of neurodevelopmental psychiatric diseases: A systematic review. Int. J. Environ. Res. Public Health,  2019, 16(8), 1318.
[http://dx.doi.org/10.3390/ijerph16081318] [PMID: 31013727] 
[47] 
Zhang, Q.; Chen, X.Z.; Huang, X.; Wang, M.; Wu, J. The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts. Neurotoxicology,  2019, 73, 199-212.
[http://dx.doi.org/10.1016/j.neuro.2019.04.007] [PMID: 31004626] 
[48] 
Wen, X.; Xiong, Y.; Qu, X.; Jin, L.; Zhou, C.; Zhang, M.; Zhang, Y. The risk of endometriosis after exposure to endocrine-disrupting chemicals: A meta-analysis of 30 epidemiology studies. Gynecol. Endocrinol.,  2019, 35(8), 645-650.
[http://dx.doi.org/10.1080/09513590.2019.1590546] [PMID: 30907174] 
[49] 
Vandenberg, L.N.; Luthi, D.; Quinerly, D.A. Plastic bodies in a plastic world: Multi-disciplinary approaches to study endocrine disrupting chemicals. J. Clean. Prod.,  2017, 140(1), 373-385.
[http://dx.doi.org/10.1016/j.jclepro.2015.01.071] 
[50] 
Vandenberg, L.N. Low dose effects challenge the evaluation of endocrine disrupting chemicals. Trends Food Sci. Technol.,  2019, 84, 58-61.
[http://dx.doi.org/10.1016/j.tifs.2018.11.029] 
[51] 
Bergman, Å.; Heindel, J.J.; Kasten, T.; Kidd, K.A.; Jobling, S.; Neira, M.; Zoeller, R.T.; Becher, G.; Bjerregaard, P.; Bornman, R.; Brandt, I.; Kortenkamp, A.; Muir, D.; Drisse, M.N.B.; Ochieng, R.; Skakkebaek, N.E.; Byléhn, A.S.; Iguchi, T.; Toppari, J.; Woodruff, T.J. The impact of endocrine disruption: A consensus statement on the state of the science. Environ. Health Perspect.,  2013, 121(4), A104-A106.
[http://dx.doi.org/10.1289/ehp.1205448] [PMID: 23548368] 
[52] 
Zoeller, R.T. Regulation of endocrine-disrupting chemicals insufficient to safeguard public health. J. Clin. Endocrinol. Metab.,  2014, 99(6), 1993-1994.
[http://dx.doi.org/10.1210/jc.2014-2285] [PMID: 24893136] 
[53] 
Zoeller, R.T.; Bergman, Å.; Becher, G.; Bjerregaard, P.; Bornman, R.; Brandt, I.; Iguchi, T.; Jobling, S.; Kidd, K.A.; Kortenkamp, A.; Skakkebaek, N.E.; Toppari, J.; Vandenberg, L.N. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ. Health,  2014, 13(1), 118.
[http://dx.doi.org/10.1186/1476-069X-13-118] [PMID: 25533907] 
[54] 
Trasande, L.; Vandenberg, L.N.; Bourguignon, J.P.; Myers, J.P.; Slama, R.; vom Saal, F.; Zoeller, R.T. Peer-reviewed and unbiased research, rather than ‘sound science’, should be used to evaluate endocrine-disrupting chemicals. J. Epidemiol. Community Health,  2016, 70(11), 1051-1056.
[http://dx.doi.org/10.1136/jech-2016-207841] [PMID: 27417427] 
[55] 
Heindel, J.J.; Skalla, L.A.; Joubert, B.R.; Dilworth, C.H.; Gray, K.A. Review of developmental origins of health and disease publications in environmental epidemiology. Reprod. Toxicol.,  2017, 68, 34-48.
[http://dx.doi.org/10.1016/j.reprotox.2016.11.011] [PMID: 27871864] 
[56] 
Kortenkamp, A. State of the Art Assessment of Endocrine Disruptors, Final Report. European Commission: Brussels,  2011, 442.
[57] 
Myers, J.P.; Zoeller, R.T.; vom Saal, F.S. A clash of old and new scientific concepts in toxicity, with important implications for public health. Environ. Health Perspect.,  2009, 117(11), 1652-1655.
[http://dx.doi.org/10.1289/ehp.0900887] [PMID: 20049113] 
[58] 
vom Saal, F.S.; Akingbemi, B.T.; Belcher, S.M.; Crain, D.A.; Crews, D.; Guidice, L.C.; Hunt, P.A.; Leranth, C.; Myers, J.P.; Nadal, A.; Olea, N.; Padmanabhan, V.; Rosenfeld, C.S.; Schneyer, A.; Schoenfelder, G.; Sonnenschein, C.; Soto, A.M.; Stahlhut, R.W.; Swan, S.H.; Vandenberg, L.N.; Wang, H.S.; Watson, C.S.; Welshons, W.V.; Zoeller, R.T. Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research. Toxicol. Sci.,  2010, 115(2), 612-613.
[http://dx.doi.org/10.1093/toxsci/kfq048] [PMID: 20164146] 
[59] 
Sheehan, D.M.; vom Saal, F.S. Low dose effects of hormones: A challenge for risk assessment. Risk Policy Report,  1997, 4, 31-39.
[60] 
vom Saal, F.S.; Sheehan, D.M. Challenging risk assessment. Forum Appl. Res. Public Policy,  1998, 13, 11-18.
[61] 
Myers, J.P.; vom Saal, F.S.; Akingbemi, B.T.; Arizono, K.; Belcher, S.; Colborn, T.; Chahoud, I.; Crain, D.A.; Farabollini, F.; Guillette, L.J., Jr; Hassold, T.; Ho, S.; Hunt, P.A.; Iguchi, T.; Jobling, S.; Kanno, J.; Laufer, H.; Marcus, M.; McLachlan, J.A.; Nadal, A.; Oehlmann, J.; Olea, N.; Palanza, P.; Parmigiani, S.; Rubin, B.S.; Schoenfelder, G.; Sonnenschein, C.; Soto, A.M.; Talsness, C.E.; Taylor, J.A.; Vandenberg, L.N.; Vandenbergh, J.G.; Vogel, S.; Watson, C.S.; Welshons, W.V.; Zoeller, R.T. Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: The case of bisphenol A. Environ. Health Perspect.,  2009, 117(3), 309-315.
[http://dx.doi.org/10.1289/ehp.0800173] [PMID: 19337501] 
[62] 
vom Saal, F.S.; Myers, J.P. Good laboratory practices are not synonymous with good scientific practices, accurate reporting, or valid data. Environ. Health Perspect.,  2010, 118(2), A60.
[http://dx.doi.org/10.1289/ehp.0901495] [PMID: 20123633] 
[63] 
Melnick, R.; Lucier, G.; Wolfe, M.; Hall, R.; Stancel, G.; Prins, G.; Gallo, M.; Reuhl, K.; Ho, S.M.; Brown, T.; Moore, J.; Leakey, J.; Haseman, J.; Kohn, M. Summary of the national toxicology program’s report of the endocrine disruptors low-dose peer review. Environ. Health Perspect.,  2002, 110(4), 427-431.
[http://dx.doi.org/10.1289/ehp.02110427] [PMID: 11940462] 
[64] 
Tyl, R.W.; Marr, M.C.; Brown, S.S.; Dolbow, E.A.; Myers, C.B. Validation of the intact rat weanling uterotrophic assay with notes on the formulation and analysis of the positive control chemical in vehicle. J. Appl. Toxicol.,  2010, 30(7), 694-698.
[http://dx.doi.org/10.1002/jat.1544] [PMID: 20981862] 
[65] 
Krishnan, S.; Kiley, J. The lowest-dose, extended-cycle combined oral contraceptive pill with continuous ethinyl estradiol in the United States: A review of the literature on ethinyl estradiol 20 μg/levonorgestrel 100 μg + ethinyl estradiol 10 μg. Int. J. Womens Health,  2010, 2, 235-239.
[PMID: 21151728] 
[66] 
Vom Saal, F.S.; Richter, C.A.; Ruhlen, R.R.; Nagel, S.C.; Timms, B.G.; Welshons, W.V. The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A. Birth Defects Res. A Clin. Mol. Teratol.,  2005, 73(3), 140-145. [Part A].
[http://dx.doi.org/10.1002/bdra.20120] [PMID: 15751043] 
[67] 
vom Saal, F.S.; Welshons, W.V. Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A. Environ. Res.,  2006, 100(1), 50-76.
[http://dx.doi.org/10.1016/j.envres.2005.09.001] [PMID: 16256977] 
[68] 
Ruhlen, R.L. Choice of animal feed can alter fetal steroid levels and mask developmental effects of endocrine disrupting chemicals. J Develop Origins Health Disease,  2011, 2(1), 36-48.
[http://dx.doi.org/10.1017/S2040174410000711] 
[69] 
Heindel, J.J.; vom Saal, F.S. Meeting report: Batch-to-batch variability in estrogenic activity in commercial animal diets--importance and approaches for laboratory animal research. Environ. Health Perspect.,  2008, 116(3), 389-393.
[http://dx.doi.org/10.1289/ehp.10524] [PMID: 18335108] 
[70] 
Koehler, K.E.; Voigt, R.C.; Thomas, S.; Lamb, B.; Urban, C.; Hassold, T.; Hunt, P.A. When disaster strikes: Rethinking caging materials. Lab Anim. (NY),  2003, 32(4), 24-27.
[http://dx.doi.org/10.1038/laban0403-24] [PMID: 19753748] 
[71] 
Howdeshell, K.L.; Peterman, P.H.; Judy, B.M.; Taylor, J.A.; Orazio, C.E.; Ruhlen, R.L.; Vom Saal, F.S.; Welshons, W.V. Bisphenol A is released from used polycarbonate animal cages into water at room temperature. Environ. Health Perspect.,  2003, 111(9), 1180-1187.
[http://dx.doi.org/10.1289/ehp.5993] [PMID: 12842771] 
[72] 
Vandenberg, L.N.; Welshons, W.V.; vom Saal, F.S.; Toutain, P.L.; Myers, J.P. Should oral gavage be abandoned in toxicity testing of endocrine disruptors? Environ. Health,  2014, 13(1), 46.
[http://dx.doi.org/10.1186/1476-069X-13-46] [PMID: 24961440] 
[73] 
vom Saal, F.S. Flaws in design, execution and interpretation limit CLARITY‐BPA’s value for risk assessments of bisphenol A. Basic Clin. Pharmacol. Toxicol.,  2019, 125(S3)(Suppl. 3), 32-43.
[http://dx.doi.org/10.1111/bcpt.13195] [PMID: 30589220] 
[74] 
Vandenberg, L.N.; Prins, G.S.; Patisaul, H.B.; Zoeller, R.T. The use and misuse of historical controls in regulatory toxicology: Lessons from the CLARITY-BPA study. Endocrinology,  2020, 161(5), bqz014.
[http://dx.doi.org/10.1210/endocr/bqz014] [PMID: 31690949] 
[75] 
Keenan, C.; Elmore, S.; Francke-Carroll, S.; Kemp, R.; Kerlin, R.; Peddada, S.; Pletcher, J.; Rinke, M.; Schmidt, S.P.; Taylor, I.; Wolf, D.C. Best practices for use of historical control data of proliferative rodent lesions. Toxicol. Pathol.,  2009, 37(5), 679-693.
[http://dx.doi.org/10.1177/0192623309336154] [PMID: 19454599] 
[76] 
Benbrook, C. Trends in the use of glyphosate herbicide in the U.S. and globally. Environ. Sci. Eur., 2015. submitted
[77] 
Mendum, T.; Stoler, E.; VanBenschoten, H.; Warner, J.C. Concentration of bisphenol A in thermal paper. Green Chem. Lett. Rev.,  2011, 4(1), 81-86.
[http://dx.doi.org/10.1080/17518253.2010.502908] 
[78] 
Geens, T.; Goeyens, L.; Covaci, A. Are potential sources for human exposure to bisphenol-A overlooked? Int. J. Hyg. Environ. Health,  2011, 214(5), 339-347.
[http://dx.doi.org/10.1016/j.ijheh.2011.04.005] [PMID: 21570349] 
[79] 
Patel, C.J.; Kerr, J.; Thomas, D.C.; Mukherjee, B.; Ritz, B.; Chatterjee, N.; Jankowska, M.; Madan, J.; Karagas, M.R.; McAllister, K.A.; Mechanic, L.E.; Fallin, M.D.; Ladd-Acosta, C.; Blair, I.A.; Teitelbaum, S.L.; Amos, C.I. Opportunities and challenges for environmental exposure assessment in population-based studies. Cancer Epidemiol. Biomarkers Prev.,  2017, 26(9), 1370-1380.
[http://dx.doi.org/10.1158/1055-9965.EPI-17-0459] [PMID: 28710076] 
[80] 
Wu, Y.; Hoffman, F.O.; Apostoaei, A.I.; Kwon, D.; Thomas, B.A.; Glass, R.; Zablotska, L.B. Methods to account for uncertainties in exposure assessment in studies of environmental exposures. Environ. Health,  2019, 18(1), 31.
[http://dx.doi.org/10.1186/s12940-019-0468-4] [PMID: 30961632] 
[81] 
Beronius, A.; Ågerstrand, M. Making the most of expert judgment in hazard and risk assessment of chemicals. Toxicol. Res. (Camb.),  2017, 6(5), 571-577.
[http://dx.doi.org/10.1039/c7tx00114b] [PMID: 30090525] 
[82] 
Woodruff, T.J.; Zeise, L.; Axelrad, D.A.; Guyton, K.Z.; Janssen, S.; Miller, M.; Miller, G.G.; Schwartz, J.M.; Alexeeff, G.; Anderson, H.; Birnbaum, L.; Bois, F.; Cogliano, V.J.; Crofton, K.; Euling, S.Y.; Foster, P.M.D.; Germolec, D.R.; Gray, E.; Hattis, D.B.; Kyle, A.D.; Luebke, R.W.; Luster, M.I.; Portier, C.; Rice, D.C.; Solomon, G.; Vandenberg, J.; Zoeller, R.T. Meeting report: Moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making. Environ. Health Perspect.,  2008, 116(11), 1568-1575.
[http://dx.doi.org/10.1289/ehp.11516] [PMID: 19057713] 
[83] 
Ingre-Khans, E.; Ågerstrand, M.; Beronius, A.; Rudén, C. Reliability and relevance evaluations of REACH data. Toxicol. Res. (Camb.),  2019, 8(1), 46-56.
[http://dx.doi.org/10.1039/C8TX00216A] [PMID: 30713660] 
[84] 
Tweedale, T. Good laboratory practices and safety assessments: Another view. Environ. Health Perspect.,  2010, 118(5), A194.
[http://dx.doi.org/10.1289/ehp.0901755] [PMID: 20439173] 
[85] 
Tweedale, A.C. Response to ‘Does GLP enhance the quality of toxicological evidence for regulatory decisions?’. Toxicol. Sci.,  2016, 154(1), kfw199.
[http://dx.doi.org/10.1093/toxsci/kfw199] [PMID: 28329812] 
[86] 
Onundi, Y.; Drake, B.A.; Malecky, R.T.; DeNardo, M.A.; Mills, M.R.; Kundu, S.; Ryabov, A.D.; Beach, E.S.; Horwitz, C.P.; Simonich, M.T.; Truong, L.; Tanguay, R.L.; Wright, L.J.; Singhal, N.; Collins, T.J. A multidisciplinary investigation of the technical and environmental performances of TAML/peroxide elimination of Bisphenol A compounds from water. Green Chem.,  2017, 19(18), 4234-4262.
[http://dx.doi.org/10.1039/C7GC01415E] 
[87] 
Geens, T.; Aerts, D.; Berthot, C.; Bourguignon, J.P.; Goeyens, L.; Lecomte, P.; Maghuin-Rogister, G.; Pironnet, A.M.; Pussemier, L.; Scippo, M.L.; Van Loco, J.; Covaci, A. A review of dietary and non-dietary exposure to bisphenol-A. Food Chem. Toxicol.,  2012, 50(10), 3725-3740.
[http://dx.doi.org/10.1016/j.fct.2012.07.059] [PMID: 22889897] 
[88] 
Hu, Y.; Zhu, Q.; Yan, X.; Liao, C.; Jiang, G. Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: A review. Environ. Res.,  2019, 178, 108732.
[http://dx.doi.org/10.1016/j.envres.2019.108732] [PMID: 31541806] 
[89] 
Corrales, J.; Kristofco, L.A.; Steele, W.B.; Yates, B.S.; Breed, C.S.; Williams, E.S.; Brooks, B.W. Global assessment of bisphenol A in the environment. Dose Response,  2015, 13(3) , 1559325815598308.
[http://dx.doi.org/10.1177/1559325815598308] [PMID: 26674671] 
[90] 
Bhatnagar, A.; Anastopoulos, I. Adsorptive removal of bisphenol A (BPA) from aqueous solution: A review. Chemosphere,  2017, 168, 885-902.
[http://dx.doi.org/10.1016/j.chemosphere.2016.10.121] [PMID: 27839878] 
[91] 
Wetherill, Y.B.; Akingbemi, B.T.; Kanno, J.; McLachlan, J.A.; Nadal, A.; Sonnenschein, C.; Watson, C.S.; Zoeller, R.T.; Belcher, S.M. In vitro molecular mechanisms of bisphenol A action. Reprod. Toxicol.,  2007, 24(2), 178-198.
[http://dx.doi.org/10.1016/j.reprotox.2007.05.010] [PMID: 17628395] 
[92] 
Dodds, E.C.; Lawson, W. Synthetic estrogenic agents without the phenanthrene nucleus. Nature,  1936, 137(3476), 996.
[http://dx.doi.org/10.1038/137996a0] 
[93] 
Vogel, S.A. The politics of plastics: The making and unmaking of bisphenol a “safety”. Am. J. Public Health,  2009, 99(S3)(Suppl. 3), S559-S566.
[http://dx.doi.org/10.2105/AJPH.2008.159228] [PMID: 19890158] 
[94] 
Acconcia, F.; Pallottini, V.; Marino, M. Molecular mechanisms of action of BPA. Dose Response,  2015, 13(4) , 1559325815610582.
[http://dx.doi.org/10.1177/1559325815610582] [PMID: 26740804] 
[95] 
Kitamura, S.; Suzuki, T.; Sanoh, S.; Kohta, R.; Jinno, N.; Sugihara, K.; Yoshihara, S.; Fujimoto, N.; Watanabe, H.; Ohta, S. Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds. Toxicol. Sci.,  2005, 84(2), 249-259.
[http://dx.doi.org/10.1093/toxsci/kfi074] [PMID: 15635150] 
[96] 
Pelch, K.E.; Li, Y.; Perera, L.; Thayer, K.A.; Korach, K.S. Characterization of estrogenic and androgenic activities for bisphenol A-like chemicals (BPs): In vitro estrogen and androgen receptors transcriptional activation, gene regulation, and binding profiles. Toxicol. Sci.,  2019, 172(1), 23-37.
[http://dx.doi.org/10.1093/toxsci/kfz173] [PMID: 31388671] 
[97] 
Li, Y.; Perera, L.; Coons, L.A.; Burns, K.A.; Tyler Ramsey, J.; Pelch, K.E.; Houtman, R.; van Beuningen, R.; Teng, C.T.; Korach, K.S. Differential in vitro biological action, coregulator interactions, and molecular dynamic analysis of bisphenol A (BPA), BPAF, and BPS Ligand–ERα complexes. Environ. Health Perspect.,  2018, 126(1), 017012.
[http://dx.doi.org/10.1289/EHP2505] [PMID: 29389661] 
[98] 
Watson, C.S.; Bulayeva, N.N.; Wozniak, A.L.; Alyea, R.A. Xenoestrogens are potent activators of nongenomic estrogenic responses. Steroids,  2007, 72(2), 124-134.
[http://dx.doi.org/10.1016/j.steroids.2006.11.002] [PMID: 17174995] 
[99] 
Nadal, A.; Fuentes, E.; Ripoll, C.; Villar-Pazos, S.; Castellano-Muñoz, M.; Soriano, S.; Martinez-Pinna, J.; Quesada, I.; Alonso-Magdalena, P. Extranuclear-initiated estrogenic actions of endocrine disrupting chemicals: Is there toxicology beyond paracelsus? J. Steroid Biochem. Mol. Biol.,  2018, 176, 16-22.
[http://dx.doi.org/10.1016/j.jsbmb.2017.01.014] [PMID: 28159674] 
[100] 
Zoeller, R.T.; Bansal, R.; Parris, C. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. Endocrinology,  2005, 146(2), 607-612.
[http://dx.doi.org/10.1210/en.2004-1018] [PMID: 15498886] 
[101] 
Kanno, J.; Onyon, L.; Haseman, J.; Fenner-Crisp, P.; Ashby, J.; Owens, W. The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: Phase 1. Environ. Health Perspect.,  2001, 109(8), 785-794.
[http://dx.doi.org/10.1289/ehp.01109785] [PMID: 11564613] 
[102] 
Kanno, J.; Onyon, L.; Peddada, S.; Ashby, J.; Jacob, E.; Owens, W. The OECD program to validate the rat uterotrophic bioassay. Phase 2: Dose-response studies. Environ. Health Perspect.,  2003, 111(12), 1530-1549.
[http://dx.doi.org/10.1289/ehp.5780] [PMID: 12948896] 
[103] 
Ohta, R.; Takagi, A.; Ohmukai, H.; Marumo, H.; Ono, A.; Matsushima, Y.; Inoue, T.; Ono, H.; Kanno, J. Ovariectomized mouse uterotrophic assay of 36 chemicals. J. Toxicol. Sci.,  2012, 37(5), 879-889.
[http://dx.doi.org/10.2131/jts.37.879] [PMID: 23037998] 
[104] 
La Merrill, M.A.; Vandenberg, L.N.; Smith, M.T.; Goodson, W.; Browne, P.; Patisaul, H.B.; Guyton, K.Z.; Kortenkamp, A.; Cogliano, V.J.; Woodruff, T.J.; Rieswijk, L.; Sone, H.; Korach, K.S.; Gore, A.C.; Zeise, L.; Zoeller, R.T. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat. Rev. Endocrinol.,  2020, 16(1), 45-57.
[http://dx.doi.org/10.1038/s41574-019-0273-8] [PMID: 31719706] 
[105] 
Vandenberg, L.N.; Hauser, R.; Marcus, M.; Olea, N.; Welshons, W.V. Human exposure to bisphenol A (BPA). Reprod. Toxicol.,  2007, 24(2), 139-177.
[http://dx.doi.org/10.1016/j.reprotox.2007.07.010] [PMID: 17825522] 
[106] 
Iribarne-Durán, L.M.; Artacho-Cordón, F.; Peña-Caballero, M.; Molina-Molina, J.M.; Jiménez-Díaz, I.; Vela-Soria, F.; Serrano, L.; Hurtado, J.A.; Fernández, M.F.; Freire, C.; Olea, N. Presence of bisphenol A and parabens in a neonatal intensive care unit: An exploratory study of potential sources of exposure. Environ. Health Perspect.,  2019, 127(11), 117004.
[http://dx.doi.org/10.1289/EHP5564] [PMID: 31774309] 
[107] 
Calafat, A.M.; Weuve, J.; Ye, X.; Jia, L.T.; Hu, H.; Ringer, S.; Huttner, K.; Hauser, R. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ. Health Perspect.,  2009, 117(4), 639-644.
[http://dx.doi.org/10.1289/ehp.0800265] [PMID: 19440505] 
[108] 
Genco, M.; Anderson-Shaw, L.; Sargis, R.M. Unwitting accomplices: Endocrine disruptors confounding clinical care. J. Clin. Endocrinol. Metab.,  2020, 105(10), dgaa358.
[http://dx.doi.org/10.1210/clinem/dgaa358] [PMID: 32614432] 
[109] 
Schecter, A.; Malik, N.; Haffner, D.; Smith, S.; Harris, T.R.; Paepke, O.; Birnbaum, L.; Bisphenol, A. Bisphenol A (BPA) in U.S. food. Environ. Sci. Technol.,  2010, 44(24), 9425-9430.
[http://dx.doi.org/10.1021/es102785d] [PMID: 21038926] 
[110] 
Liao, C.; Liu, F.; Kannan, K. Occurrence of and dietary exposure to parabens in foodstuffs from the United States. Environ. Sci. Technol.,  2013, 47(8), 3918-3925.
[http://dx.doi.org/10.1021/es400724s] [PMID: 23506043] 
[111] 
Cunha, S.C.; Inácio, T.; Almada, M.; Ferreira, R.; Fernandes, J.O. Gas chromatography–mass spectrometry analysis of nine bisphenols in canned meat products and human risk estimation. Food Res. Int.,  2020, 135, 109293.
[http://dx.doi.org/10.1016/j.foodres.2020.109293] [PMID: 32527484] 
[112] 
Kim, S.; Lee, I.; Lim, J.E.; Lee, A.; Moon, H.B.; Park, J.; Choi, K. Dietary contribution to body burden of bisphenol A and bisphenol S among mother-children pairs. Sci. Total Environ.,  2020, 744, 140856.
[http://dx.doi.org/10.1016/j.scitotenv.2020.140856] [PMID: 32721674] 
[113] 
González, N.; Marquès, M.; Cunha, S.C.; Fernandes, J.O.; Domingo, J.L.; Nadal, M. Biomonitoring of co-exposure to bisphenols by consumers of canned foodstuffs. Environ. Int.,  2020, 140, 105760.
[http://dx.doi.org/10.1016/j.envint.2020.105760] [PMID: 32371307] 
[114] 
Soto, A.M.; Schaeberle, C.; Maier, M.S.; Sonnenschein, C.; Maffini, M.V. Evidence of absence: Estrogenicity assessment of a new food-contact coating and the bisphenol used in its synthesis. Environ. Sci. Technol.,  2017, 51(3), 1718-1726.
[http://dx.doi.org/10.1021/acs.est.6b04704] [PMID: 28098991] 
[115] 
US FDA. Update on bisphenol A (BPA) for use in food: January 2010. 2010. September 21, 2010];  Available from: http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm064437.htm
[116] 
Rochester, J.R.; Bolden, A.L. Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes. Environ. Health Perspect.,  2015, 123(7), 643-650.
[http://dx.doi.org/10.1289/ehp.1408989] [PMID: 25775505] 
[117] 
Gys, C. Short-term variability of bisphenols in spot, morning void and 24-hour urine samples. Environ Pollut,  2021, 268(Pt A), 115747.
[118] 
Dodson, R.E.; Boronow, K.E.; Susmann, H.; Udesky, J.O.; Rodgers, K.M.; Weller, D.; Woudneh, M.; Brody, J.G.; Rudel, R.A. Consumer behavior and exposure to parabens, bisphenols, triclosan, dichlorophenols, and benzophenone-3: Results from a crowdsourced biomonitoring study. Int. J. Hyg. Environ. Health,  2020, 230, 113624.
[http://dx.doi.org/10.1016/j.ijheh.2020.113624] [PMID: 33011057] 
[119] 
Kolla, S.; Morcos, M.; Martin, B.; Vandenberg, L.N. Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development. Reprod. Toxicol.,  2018, 78, 50-59.
[http://dx.doi.org/10.1016/j.reprotox.2018.03.003] [PMID: 29526645] 
[120] 
Catanese, M.C.; Vandenberg, L.N.; Bisphenol, S. BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters. Endocrinology,  2017, 158(3), 516-530.
[PMID: 28005399] 
[121] 
Le Fol, V.; Aït-Aïssa, S.; Sonavane, M.; Porcher, J.M.; Balaguer, P.; Cravedi, J.P.; Zalko, D.; Brion, F. In vitro and in vivo estrogenic activity of BPA, BPF and BPS in zebrafish-specific assays. Ecotoxicol. Environ. Saf.,  2017, 142, 150-156.
[http://dx.doi.org/10.1016/j.ecoenv.2017.04.009] [PMID: 28407500] 
[122] 
US FDA. Draft assessment of bisphenol A for use in food contact applications. 2011. 8 January 2011];  Available from: http://www.fda.gov/ohrms/dockets/ac/08/briefing/2008-0038b1_01_02_FDA%20BPA%20Draft%20Assessment.pdf
[123] 
EFSA. Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs. EFSA J.,  2015, 13(1), 3978.
[http://dx.doi.org/10.2903/j.efsa.2015.3978] 
[124] 
Xue, J.; Liu, W.; Kannan, K. Bisphenols, benzophenones, and bisphenol A diglycidyl ethers in textiles and infant clothing. Environ. Sci. Technol.,  2017, 51(9), 5279-5286.
[http://dx.doi.org/10.1021/acs.est.7b00701] [PMID: 28368574] 
[125] 
Wang, L.; Zhang, Y.; Liu, Y.; Gong, X.; Zhang, T.; Sun, H. Widespread occurrence of bisphenol A in daily clothes and its high exposure risk in humans. Environ. Sci. Technol.,  2019, 53(12), 7095-7102.
[http://dx.doi.org/10.1021/acs.est.9b02090] [PMID: 31124657] 
[126] 
Liao, C.; Kannan, K. High levels of bisphenol A in paper currencies from several countries, and implications for dermal exposure. Environ. Sci. Technol.,  2011, 45(16), 6761-6768.
[http://dx.doi.org/10.1021/es200977t] [PMID: 21744851] 
[127] 
Hormann, A.M.; vom Saal, F.S.; Nagel, S.C.; Stahlhut, R.W.; Moyer, C.L.; Ellersieck, M.R.; Welshons, W.V.; Toutain, P.L.; Taylor, J.A. Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA). PLoS One,  2014, 9(10), e110509.
[http://dx.doi.org/10.1371/journal.pone.0110509] [PMID: 25337790] 
[128] 
Marzouk, T.; Sathyanarayana, S.; Kim, A.S.; Seminario, A.L.; McKinney, C.M. A systematic review of exposure to Bisphenol A from dental treatment. JDR Clin. Trans. Res.,  2019, 4(2), 106-115.
[http://dx.doi.org/10.1177/2380084418816079] [PMID: 30931707] 
[129] 
Dodson, R.E.; Nishioka, M.; Standley, L.J.; Perovich, L.J.; Brody, J.G.; Rudel, R.A. Endocrine disruptors and asthma-associated chemicals in consumer products. Environ. Health Perspect.,  2012, 120(7), 935-943.
[http://dx.doi.org/10.1289/ehp.1104052] [PMID: 22398195] 
[130] 
Bernier, M.R.; Vandenberg, L.N. Handling of thermal paper: Implications for dermal exposure to bisphenol A and its alternatives. PLoS One,  2017, 12(6), e0178449.
[http://dx.doi.org/10.1371/journal.pone.0178449] [PMID: 28570582] 
[131] 
Vandenberg, L.N.; Chahoud, I.; Padmanabhan, V.; Paumgartten, F.J.R.; Schoenfelder, G. Biomonitoring studies should be used by regulatory agencies to assess human exposure levels and safety of bisphenol A. Environ. Health Perspect.,  2010, 118(8), 1051-1054.
[http://dx.doi.org/10.1289/ehp.0901717] [PMID: 20444668] 
[132] 
Vandenberg, L.N.; Chahoud, I.; Heindel, J.J.; Padmanabhan, V.; Paumgartten, F.J.R.; Schoenfelder, G. Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A. Environ. Health Perspect.,  2010, 118(8), 1055-1070.
[http://dx.doi.org/10.1289/ehp.0901716] [PMID: 20338858] 
[133] 
Vandenberg, L.N. Exposure to bisphenol A in Canada: Invoking the precautionary principle. CMAJ,  2011, 183(11), 1265-1270.
[http://dx.doi.org/10.1503/cmaj.101408] [PMID: 21343266] 
[134] 
Carwile, J.L.; Luu, H.T.; Bassett, L.S.; Driscoll, D.A.; Yuan, C.; Chang, J.Y.; Ye, X.; Calafat, A.M.; Michels, K.B. Polycarbonate bottle use and urinary bisphenol A concentrations. Environ. Health Perspect.,  2009, 117(9), 1368-1372.
[http://dx.doi.org/10.1289/ehp.0900604] [PMID: 19750099] 
[135] 
Carwile, J.L.; Ye, X.; Zhou, X.; Calafat, A.M.; Michels, K.B. Canned soup consumption and urinary bisphenol A: A randomized crossover trial. JAMA,  2011, 306(20), 2218-2220.
[http://dx.doi.org/10.1001/jama.2011.1721] [PMID: 22110104] 
[136] 
Rudel, R.A.; Gray, J.M.; Engel, C.L.; Rawsthorne, T.W.; Dodson, R.E.; Ackerman, J.M.; Rizzo, J.; Nudelman, J.L.; Brody, J.G. Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: Findings from a dietary intervention. Environ. Health Perspect.,  2011, 119(7), 914-920.
[http://dx.doi.org/10.1289/ehp.1003170] [PMID: 21450549] 
[137] 
vom Saal, F.S.; Akingbemi, B.T.; Belcher, S.M.; Birnbaum, L.S.; Crain, D.A.; Eriksen, M.; Farabollini, F.; Guillette, L.J., Jr; Hauser, R.; Heindel, J.J.; Ho, S.M.; Hunt, P.A.; Iguchi, T.; Jobling, S.; Kanno, J.; Keri, R.A.; Knudsen, K.E.; Laufer, H.; LeBlanc, G.A.; Marcus, M.; McLachlan, J.A.; Myers, J.P.; Nadal, A.; Newbold, R.R.; Olea, N.; Prins, G.S.; Richter, C.A.; Rubin, B.S.; Sonnenschein, C.; Soto, A.M.; Talsness, C.E.; Vandenbergh, J.G.; Vandenberg, L.N.; Walser-Kuntz, D.R.; Watson, C.S.; Welshons, W.V.; Wetherill, Y.; Zoeller, R.T. Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod. Toxicol.,  2007, 24(2), 131-138.
[http://dx.doi.org/10.1016/j.reprotox.2007.07.005] [PMID: 17768031] 
[138] 
Peretz, J.; Vrooman, L.; Ricke, W.A.; Hunt, P.A.; Ehrlich, S.; Hauser, R.; Padmanabhan, V.; Taylor, H.S.; Swan, S.H.; VandeVoort, C.A.; Flaws, J.A. Bisphenol a and reproductive health: Update of experimental and human evidence, 2007-2013. Environ. Health Perspect.,  2014, 122(8), 775-786.
[http://dx.doi.org/10.1289/ehp.1307728] [PMID: 24896072] 
[139] 
Braun, J.M.; Yolton, K.; Dietrich, K.N.; Hornung, R.; Ye, X.; Calafat, A.M.; Lanphear, B.P. Prenatal bisphenol A exposure and early childhood behavior. Environ. Health Perspect.,  2009, 117(12), 1945-1952.
[http://dx.doi.org/10.1289/ehp.0900979] [PMID: 20049216] 
[140] 
Harley, K.G.; Schall, R.A.; Chevrier, J.; Tyler, K.; Aguirre, H.; Bradman, A.; Holland, N.T.; Lustig, R.H.; Calafat, A.M.; Eskenazi, B. Prenatal and postnatal bisphenol A exposure and body mass index in childhood in the CHAMACOS cohort. Environ. Health Perspect.,  2013, 121(4), 514-520.
[http://dx.doi.org/10.1289/ehp.1205548] [PMID: 23416456] 
[141] 
Chevrier, J.; Gunier, R.B.; Bradman, A.; Holland, N.T.; Calafat, A.M.; Eskenazi, B.; Harley, K.G. Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid function in the CHAMACOS study. Environ. Health Perspect.,  2013, 121(1), 138-144.
[http://dx.doi.org/10.1289/ehp.1205092] [PMID: 23052180] 
[142] 
Nesan, D.; Kurrasch, D.M. Gestational exposure to common endocrine disrupting chemicals and their impact on neurodevelopment and behavior. Annu. Rev. Physiol.,  2020, 82(1), 177-202.
[http://dx.doi.org/10.1146/annurev-physiol-021119-034555] [PMID: 31738670] 
[143] 
Hoepner, L.A. Bisphenol A: A narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma. Environ. Res.,  2019, 173, 54-68.
[http://dx.doi.org/10.1016/j.envres.2019.03.012] [PMID: 30897403] 
[144] 
Hu, Y.; Wen, S.; Yuan, D.; Peng, L.; Zeng, R.; Yang, Z.; Liu, Q.; Xu, L.; Kang, D. The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: A systematic review and meta-analysis. Gynecol. Endocrinol.,  2018, 34(5), 370-377.
[http://dx.doi.org/10.1080/09513590.2017.1405931] [PMID: 29191127] 
[145] 
Karwacka, A.; Zamkowska, D.; Radwan, M.; Jurewicz, J. Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: An overview of current epidemiological evidence. Hum. Fertil. (Camb.),  2019, 22(1), 2-25.
[http://dx.doi.org/10.1080/14647273.2017.1358828] [PMID: 28758506] 
[146] 
Mathew, H.; Mahalingaiah, S. Do prenatal exposures pose a real threat to ovarian function? Bisphenol A as a case study. Reproduction,  2019, 157(4), R143-R157.
[http://dx.doi.org/10.1530/REP-17-0734] [PMID: 30689546] 
[147] 
Bao, W.; Liu, B.; Rong, S.; Dai, S.Y.; Trasande, L.; Lehmler, H.J. Association between Bisphenol A exposure and risk of all-cause and cause-specific mortality in US adults. JAMA Netw. Open,  2020, 3(8), e2011620.
[http://dx.doi.org/10.1001/jamanetworkopen.2020.11620] [PMID: 32804211] 
[148] 
Vom Saal, F.S.; Vandenberg, L.N. Update on the health effects of bisphenol A: Overwhelming evidence of harm. Endocrinology,  2021, 162(3), bqaa171.
[149] 
Palanza, P.; Nagel, S.C.; Parmigiani, S.; vom Saal, F.S. Perinatal exposure to endocrine disruptors: Sex, timing and behavioral endpoints. Curr. Opin. Behav. Sci.,  2016, 7, 69-75.
[http://dx.doi.org/10.1016/j.cobeha.2015.11.017] [PMID: 27019862] 
[150] 
Paulose, T.; Speroni, L.; Sonnenschein, C.; Soto, A.M. Estrogens in the wrong place at the wrong time: Fetal BPA exposure and mammary cancer. Reprod. Toxicol.,  2015, 54, 58-65.
[http://dx.doi.org/10.1016/j.reprotox.2014.09.012] [PMID: 25277313] 
[151] 
Rubin, B.S.; Schaeberle, C.M.; Soto, A.M. The case for BPA as an Obesogen: Contributors to the controversy. Front. Endocrinol. (Lausanne),  2019, 10, 30.
[http://dx.doi.org/10.3389/fendo.2019.00030] [PMID: 30787907] 
[152] 
Hessel, E.V.S.; Ezendam, J.; van Broekhuizen, F.A.; Hakkert, B.; DeWitt, J.; Granum, B.; Guzylack, L.; Lawrence, B.P.; Penninks, A.; Rooney, A.A.; Piersma, A.H.; van Loveren, H. Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI. Reprod. Toxicol.,  2016, 65, 448-456.
[http://dx.doi.org/10.1016/j.reprotox.2016.06.020] [PMID: 27352639] 
[153] 
Gao, X.; Wang, H.S. Impact of bisphenol a on the cardiovascular system - epidemiological and experimental evidence and molecular mechanisms. Int. J. Environ. Res. Public Health,  2014, 11(8), 8399-8413.
[http://dx.doi.org/10.3390/ijerph110808399] [PMID: 25153468] 
[154] 
Program, N.T. Carcinogenesis Bioassay of Bisphenol A (CAS No. 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study). Natl. Toxicol. Program Tech. Rep. Ser.,  1982, 215, 1-116.
[PMID: 12778220] 
[155] 
Careghini, A.; Mastorgio, A.F.; Saponaro, S.; Sezenna, E. Bisphenol A, nonylphenols, benzophenones, and benzotriazoles in soils, groundwater, surface water, sediments, and food: A review. Environ. Sci. Pollut. Res. Int.,  2015, 22(8), 5711-5741.
[http://dx.doi.org/10.1007/s11356-014-3974-5] [PMID: 25548011] 
[156] 
US EPA Bisphenol A Action Plan, 2010.  Available from: https://www.epa.gov/sites/default/files/2015-09/documents/bpa_action_plan.pdf
[157] 
Shelby, M.D. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. NTP CERHR MON, 2008. (22):v, vii-ix, 1-64 passim.
[PMID: 19407859] 
[158] 
Aungst, J.; Anderson, S. Memorandum: Final report for the review of literature and data on BPA, 2014. Available from: https://www.fda.gov/media/90546/download
[159] 
Tyl, R.W.; Myers, C.B.; Marr, M.C.; Sloan, C.S.; Castillo, N.P.; Veselica, M.M.; Seely, J.C.; Dimond, S.S.; Van Miller, J.P.; Shiotsuka, R.N.; Beyer, D.; Hentges, S.G.; Waechter, J.M., Jr Two-generation reproductive toxicity study of dietary bisphenol A in CD-1 (Swiss) mice. Toxicol. Sci.,  2008, 104(2), 362-384.
[http://dx.doi.org/10.1093/toxsci/kfn084] [PMID: 18445619] 
[160] 
Pouzaud, F.; Thierry-Mieg, M.; Burga, K.; Vérines-Jouin, L.; Fiore, K.; Beausoleil, C.; Michel, C.; Rousselle, C.; Pasquier, E. Concerns related to ED-mediated effects of Bisphenol A and their regulatory consideration. Mol. Cell. Endocrinol.,  2018, 475, 92-106.
[http://dx.doi.org/10.1016/j.mce.2018.02.002] [PMID: 29428396] 
[161] 
Kassotis, C.D.; Vandenberg, L.N.; Demeneix, B.A.; Porta, M.; Slama, R.; Trasande, L. Endocrine-disrupting chemicals: Economic, regulatory, and policy implications. Lancet Diabetes Endocrinol.,  2020, 8(8), 719-730.
[http://dx.doi.org/10.1016/S2213-8587(20)30128-5] [PMID: 32707119] 
[162] 
ECHA. Bisphenol A. unknown year (Accessed 11 October 2020)  Available from: https://echa.europa.eu/-/bisphenol-s-has-replaced-bisphenol-a-in-thermal-paper
[163] 
Dupuis, A.; Rabouan, S.; Migeot, V.; Venisse, N. BPA and risk assessment. Lancet Diabetes Endocrinol.,  2020, 8(4), 270-271.
[http://dx.doi.org/10.1016/S2213-8587(20)30069-3] [PMID: 32197111] 
[164] 
Hunt, P.A.; vom Saal, F.S.; Stahlhut, R.; Gerona, R. BPA and risk assessment – Authors’ reply. Lancet Diabetes Endocrinol.,  2020, 8(4), 271-272.
[http://dx.doi.org/10.1016/S2213-8587(20)30071-1] [PMID: 32197112] 
[165] 

Science and Decisions: Advancing Risk Assessment; The National Academies Press: Washington, DC, 2009. 
[http://dx.doi.org/10.17226/12209] [PMID: 25009905] 
[166] 
Tweedale, A.C. Systematic review for pre-market risk assessment. Environ. Int.,  2016, 94, 626.
[http://dx.doi.org/10.1016/j.envint.2016.06.028] [PMID: 27389664] 
[167] 
Ågerstrand, M.; Beronius, A. Weight of evidence evaluation and systematic review in EU chemical risk assessment: Foundation is laid but guidance is needed. Environ. Int.,  2016, 92-93, 590-596.
[http://dx.doi.org/10.1016/j.envint.2015.10.008] [PMID: 26682868] 
[168] 
Woodruff, T.J.; Sutton, P. An evidence-based medicine methodology to bridge the gap between clinical and environmental health sciences. Health Aff. (Millwood),  2011, 30(5), 931-937.
[http://dx.doi.org/10.1377/hlthaff.2010.1219] [PMID: 21555477] 
[169] 
Whaley, P.; Aiassa, E.; Beausoleil, C.; Beronius, A.; Bilotta, G.; Boobis, A.; de Vries, R.; Hanberg, A.; Hoffmann, S.; Hunt, N.; Kwiatkowski, C.F.; Lam, J.; Lipworth, S.; Martin, O.; Randall, N.; Rhomberg, L.; Rooney, A.A.; Schünemann, H.J.; Wikoff, D.; Wolffe, T.; Halsall, C. Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). Environ. Int.,  2020, 143, 105926.
[http://dx.doi.org/10.1016/j.envint.2020.105926] [PMID: 32653802] 
[170] 
Vandenberg, L.N.; Ågerstrand, M.; Beronius, A.; Beausoleil, C.; Bergman, Å.; Bero, L.A.; Bornehag, C.G.; Boyer, C.S.; Cooper, G.S.; Cotgreave, I.; Gee, D.; Grandjean, P.; Guyton, K.Z.; Hass, U.; Heindel, J.J.; Jobling, S.; Kidd, K.A.; Kortenkamp, A.; Macleod, M.R.; Martin, O.V.; Norinder, U.; Scheringer, M.; Thayer, K.A.; Toppari, J.; Whaley, P.; Woodruff, T.J.; Rudén, C. A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. Environ. Health,  2016, 15(1), 74.
[http://dx.doi.org/10.1186/s12940-016-0156-6] [PMID: 27412149] 
[171] 
Woodruff, T.J.; Sutton, P. The Navigation Guide systematic review methodology: A rigorous and transparent method for translating environmental health science into better health outcomes. Environ. Health Perspect.,  2014, 122(10), 1007-1014.
[http://dx.doi.org/10.1289/ehp.1307175] [PMID: 24968373] 
[172] 
Rooney, A.A.; Boyles, A.L.; Wolfe, M.S.; Bucher, J.R.; Thayer, K.A. Systematic review and evidence integration for literature-based environmental health science assessments. Environ. Health Perspect.,  2014, 122(7), 711-718.
[http://dx.doi.org/10.1289/ehp.1307972] [PMID: 24755067] 
[173] 
Krauth, D.; Woodruff, T.J.; Bero, L. Instruments for assessing risk of bias and other methodological criteria of published animal studies: A systematic review. Environ. Health Perspect.,  2013, 121(9), 985-992.
[http://dx.doi.org/10.1289/ehp.1206389] [PMID: 23771496] 
[174] 
Klimisch, H.J.; Andreae, M.; Tillmann, U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul. Toxicol. Pharmacol.,  1997, 25(1), 1-5.
[http://dx.doi.org/10.1006/rtph.1996.1076] [PMID: 9056496] 
[175] 
Molander, L.; Ågerstrand, M.; Beronius, A.; Hanberg, A.; Rudén, C. Science in Risk Assessment and Policy (SciRAP): An online resource for evaluating and reporting in vivo (Eco)toxicity studies. Hum. Ecol. Risk Assess.,  2015, 21(3), 753-762.
[http://dx.doi.org/10.1080/10807039.2014.928104] 
[176] 
Kase, R.; Korkaric, M.; Werner, I.; Ågerstrand, M. Criteria for Reporting and Evaluating ecotoxicity Data (CRED): Comparison and perception of the Klimisch and CRED methods for evaluating reliability and relevance of ecotoxicity studies. Environ. Sci. Eur.,  2016, 28(1), 7.
[http://dx.doi.org/10.1186/s12302-016-0073-x] [PMID: 27752436] 
[177] 
Beronius, A.; Vandenberg, L.N. Using systematic reviews for hazard and risk assessment of endocrine disrupting chemicals. Rev. Endocr. Metab. Disord.,  2015, 16(4), 273-287.
[http://dx.doi.org/10.1007/s11154-016-9334-7] [PMID: 26847432] 
[178] 
Tweedale, A.C. The inadequacies of pre-market chemical risk assessment’s toxicity studies-the implications. J. Appl. Toxicol.,  2017, 37(1), 92-104.
[http://dx.doi.org/10.1002/jat.3396] [PMID: 27785833] 
[179] 
Ågerstrand, M.; Breitholtz, M.; Rudén, C. Comparison of four different methods for reliability evaluation of ecotoxicity data: A case study of non-standard test data used in environmental risk assessments of pharmaceutical substances. Environ. Sci. Eur.,  2011, 23(1), 17.
[http://dx.doi.org/10.1186/2190-4715-23-17] 
[180] 
Eick, S.M.; Goin, D.E.; Chartres, N.; Lam, J.; Woodruff, T.J. Assessing risk of bias in human environmental epidemiology studies using three tools: Different conclusions from different tools. Syst. Rev.,  2020, 9(1), 249.
[http://dx.doi.org/10.1186/s13643-020-01490-8] [PMID: 33121530] 
[181] 
National Academies of Sciences, E. and Medicine. Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals; The National Academies Press: Washington, DC, 2017, p. 180.
[182] 
Swan, S.H. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ. Res.,  2008, 108(2), 177-184.
[http://dx.doi.org/10.1016/j.envres.2008.08.007] [PMID: 18949837] 
[183] 
Cao, J.; Lin, Y.; Guo, L.H.; Zhang, A.Q.; Wei, Y.; Yang, Y. Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins. Toxicology,  2010, 277(1-3), 20-28.
[http://dx.doi.org/10.1016/j.tox.2010.08.012] [PMID: 20804816] 
[184] 
Colborn, T.; vom Saal, F.S.; Soto, A.M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect.,  1993, 101(5), 378-384.
[http://dx.doi.org/10.1289/ehp.93101378] [PMID: 8080506] 
[185] 
Beronius, A.; Hanberg, A.; Zilliacus, J.; Rudén, C. Bridging the gap between academic research and regulatory health risk assessment of Endocrine Disrupting Chemicals. Curr. Opin. Pharmacol.,  2014, 19, 99-104.
[http://dx.doi.org/10.1016/j.coph.2014.08.005] [PMID: 25238457] 
[186] 
Beronius, A.; Molander, L.; Rudén, C.; Hanberg, A. Facilitating the use of non-standard in vivo studies in health risk assessment of chemicals: A proposal to improve evaluation criteria and reporting. J. Appl. Toxicol.,  2014, 34(6), 607-617.
[http://dx.doi.org/10.1002/jat.2991] [PMID: 24481642] 
[187] 
Beronius, A.; Rudén, C.; Håkansson, H.; Hanberg, A. Risk to all or none? Reprod. Toxicol.,  2010, 29(2), 132-146.
[http://dx.doi.org/10.1016/j.reprotox.2009.11.007] [PMID: 19931376] 
[188] 
Rochester, J.R.; Bolden, A.L.; Kwiatkowski, C.F. Prenatal exposure to bisphenol A and hyperactivity in children: A systematic review and meta-analysis. Environ. Int.,  2018, 114, 343-356.
[http://dx.doi.org/10.1016/j.envint.2017.12.028] [PMID: 29525285] 
[189] 
Ren, X.; Zhang, T.; Chen, X.; Wei, X.; Tian, Y.; Li, G.; Zhang, X.; Zhang, W.; You, Z.; Wang, S.; Qin, C. Early-life exposure to bisphenol A and reproductive-related outcomes in rodent models: A systematic review and meta-analysis. Aging (Albany NY),  2020, 12(18), 18099-18126.
[http://dx.doi.org/10.18632/aging.103620] [PMID: 32996894] 
[190] 
Wu, W.; Li, M.; Liu, A.; Wu, C.; Li, D.; Deng, Q.; Zhang, B.; Du, J.; Gao, X.; Hong, Y. Bisphenol A and the risk of obesity a systematic review with meta-analysis of the epidemiological evidence. Dose Response,  2020, 18(2) , 1559325820916949. 
[http://dx.doi.org/10.1177/1559325820916949] [PMID: 32313524] 
[191] 
Wassenaar, P.N.H.; Trasande, L.; Legler, J. Systematic review and meta-analysis of early-life exposure to Bisphenol A and obesity-related outcomes in rodents. Environ. Health Perspect.,  2017, 125(10), 106001.
[http://dx.doi.org/10.1289/EHP1233] [PMID: 28982642] 
[192] 
Rancière, F.; Lyons, J.G.; Loh, V.H.Y.; Botton, J.; Galloway, T.; Wang, T.; Shaw, J.E.; Magliano, D.J. Bisphenol A and the risk of cardiometabolic disorders: A systematic review with meta-analysis of the epidemiological evidence. Environ. Health,  2015, 14(1), 46.
[http://dx.doi.org/10.1186/s12940-015-0036-5] [PMID: 26026606] 
[193] 
Zhou, Z.; Lei, Y.; Wei, W.; Zhao, Y.; Jiang, Y.; Wang, N.; Li, X.; Chen, X. Association between prenatal exposure to bisphenol a and birth outcomes. Medicine (Baltimore),  2019, 98(44), e17672.
[http://dx.doi.org/10.1097/MD.0000000000017672] [PMID: 31689782] 
[194] 
Pergialiotis, V.; Kotrogianni, P.; Christopoulos-Timogiannakis, E.; Koutaki, D.; Daskalakis, G.; Papantoniou, N. Bisphenol A and adverse pregnancy outcomes: A systematic review of the literature. J. Matern. Fetal Neonatal Med.,  2018, 31(24), 3320-3327.
[http://dx.doi.org/10.1080/14767058.2017.1368076] [PMID: 28805116] 
[195] 
Xie, M.Y.; Ni, H.; Zhao, D.S.; Wen, L.Y.; Li, K.S.; Yang, H.H.; Wang, S.S.; Zhang, H.; Su, H. Exposure to Bisphenol A and the development of asthma: A systematic review of cohort studies. Reprod. Toxicol.,  2016, 65, 224-229.
[http://dx.doi.org/10.1016/j.reprotox.2016.08.007] [PMID: 27542534] 
[196] 
Hoffmann, S.; de Vries, R.B.M.; Stephens, M.L.; Beck, N.B.; Dirven, H.A.A.M.; Fowle, J.R., III; Goodman, J.E.; Hartung, T.; Kimber, I.; Lalu, M.M.; Thayer, K.; Whaley, P.; Wikoff, D.; Tsaioun, K. A primer on systematic reviews in toxicology. Arch. Toxicol.,  2017, 91(7), 2551-2575.
[http://dx.doi.org/10.1007/s00204-017-1980-3] [PMID: 28501917] 
[197] 
Singla, V.I.; Sutton, P.M.; Woodruff, T.J. The environmental protection agency toxic substances control act systematic review method may curtail science used to inform policies, with profound implications for public health. Am. J. Public Health,  2019, 109(7), 982-984.
[http://dx.doi.org/10.2105/AJPH.2019.305068] [PMID: 31166745] 
[198] 
Molander, L. Combining web-based tools for transparent evaluation of data for risk assessment: Developmental effects of bisphenol A on the mammary gland as a case study. J. Appl. Toxicol.,  2016, 37(3), 319-330.
[http://dx.doi.org/10.1002/jat.3363] [PMID: 27488142] 
[199] 
Wolffe, T.A.M.; Whaley, P.; Halsall, C.; Rooney, A.A.; Walker, V.R. Systematic evidence maps as a novel tool to support evidence-based decision-making in chemicals policy and risk management. Environ. Int.,  2019, 130, 104871.
[http://dx.doi.org/10.1016/j.envint.2019.05.065] [PMID: 31254867] 
[200] 
Howard, B.E.; Phillips, J.; Tandon, A.; Maharana, A.; Elmore, R.; Mav, D.; Sedykh, A.; Thayer, K.; Merrick, B.A.; Walker, V.; Rooney, A.; Shah, R.R. SWIFT-Active Screener: Accelerated document screening through active learning and integrated recall estimation. Environ. Int.,  2020, 138, 105623.
[http://dx.doi.org/10.1016/j.envint.2020.105623] [PMID: 32203803] 
[201] 
Howard, B.E.; Phillips, J.; Miller, K.; Tandon, A.; Mav, D.; Shah, M.R.; Holmgren, S.; Pelch, K.E.; Walker, V.; Rooney, A.A.; Macleod, M.; Shah, R.R.; Thayer, K. SWIFT-Review: A text-mining workbench for systematic review. Syst. Rev.,  2016, 5(1), 87.
[http://dx.doi.org/10.1186/s13643-016-0263-z] [PMID: 27216467] 
[202] 
Pelch, K.; Wignall, J.A.; Goldstone, A.E.; Ross, P.K.; Blain, R.B.; Shapiro, A.J.; Holmgren, S.D.; Hsieh, J.H.; Svoboda, D.; Auerbach, S.S.; Parham, F.M.; Masten, S.A.; Walker, V.; Rooney, A.; Thayer, K.A. A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives. Toxicology,  2019, 424, 152235.
[http://dx.doi.org/10.1016/j.tox.2019.06.006] [PMID: 31201879] 
[203] 
Elliott, J.H.; Turner, T.; Clavisi, O.; Thomas, J.; Higgins, J.P.T.; Mavergames, C.; Gruen, R.L. Living systematic reviews: An emerging opportunity to narrow the evidence-practice gap. PLoS Med.,  2014, 11(2), e1001603.
[http://dx.doi.org/10.1371/journal.pmed.1001603] [PMID: 24558353] 
[204] 
Vandvik, P.O.; Brignardello-Petersen, R.; Guyatt, G.H. Living cumulative network meta-analysis to reduce waste in research: A paradigmatic shift for systematic reviews? BMC Med.,  2016, 14(1), 59.
[http://dx.doi.org/10.1186/s12916-016-0596-4] [PMID: 27025849] 
[205] 
Cohen Hubal, E.A.; Frank, J.J.; Nachman, R.; Angrish, M.; Deziel, N.C.; Fry, M.; Tornero-Velez, R.; Kraft, A.; Lavoie, E. Advancing systematic-review methodology in exposure science for environmental health decision making. J. Expo. Sci. Environ. Epidemiol.,  2020, 30(6), 906-916.
[http://dx.doi.org/10.1038/s41370-020-0236-0] [PMID: 32467626] 
[206] 
Thayer, K.A.; Pelch, K.E.; Birnbaum, L.S.; Bucher, J.R. Bisphenols: More unnecessary surprises. Endocr. Disruptors (Austin),  2016, 4(1), e1131032.
[http://dx.doi.org/10.1080/23273747.2015.1131032] 
[207] 
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Endocrine, Metabolic & Immune Disorders - Drug Targets

Systematic Review Methodologies and Endocrine Disrupting Chemicals: Improving Evaluations of the Plastic Monomer Bisphenol A

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