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Current Neurovascular Research

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ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

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Research Article

Association Between Serum Lipid Levels and Severe Headache or Migraine in Representative American Population: A Cross-sectional Study

Author(s): Wenjing Ge, Lijie Gao, Yang Zhang, Kongyuan Wu, Ning Chen and Li He*

Volume 18, Issue 3, 2021

Published on: 23 September, 2021

Page: [333 - 342] Pages: 10

DOI: 10.2174/1567202618666210923145635

open access plus

Abstract

Background: The relationship between serum lipids and migraine remains controversial.

Objective: This study aimed to analyze the association between serum lipids and severe headache or migraine in the general population.

Methods: Data were collected from a nationally representative sample of participants in the National Health and Nutrition Examination Survey from 1999 to 2004. Interviewers recorded self-reported severe headaches or migraines and whether pain lasted for more than 24 h in three months. A weighted general linear model was used to estimate the association between serum lipids and severe headache or migraine. Regression analyses were performed after adjusting for age, sex, race, energy intake, sodium intake, etc. Subgroup analyses were performed using the same regression model.

Results: We included 5,937 individuals in the study, with a weighted mean age of 45.8 years. Males accounted for 47.6% of the participants. After adjusting for covariates, a non-significant association was found between migraine and total cholesterol (odds ratio=0.96, 95% confidence interval= 0.85, 1.05; P=0.32), low-density lipoprotein cholesterol (odds ratio=0.96; 95% confidence interval= 0.75, 1.17, P=0.55), and high-density lipoprotein cholesterol (odds ratio=0.99; 95% confidence interval=0.49, 1.59, P=0.58) in the continuous form. In subgroup analyses, no significant association was found between total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and self-reported severe headache or migraine.

Conclusion: Total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were not significantly associated with severe headache or migraine in the general American population after adjusting for covariates. The supporting information for measuring common serum lipids in general headaches and migraines is insufficient.

Keywords: Severe headache and migraine, low-density lipoprotein cholesterol, total triglyceride, high-density lipoprotein cholesterol, national health, nutrition examination survey.

« Previous Next »
[1]
Steiner TJ, Stovner LJ, Jensen R, Uluduz D, Katsarava Z. Migraine remains second among the world’s causes of disability, and first among young women: Findings from GBD2019. J Headache Pain 2020; 21(1): 137.
[http://dx.doi.org/10.1186/s10194-020-01208-0] [PMID: 33267788]
[2]
Steiner TJ, Jensen R, Katsarava Z, et al. Aids to management of headache disorders in primary care (2nd edition): On behalf of the European Headache Federation and Lifting the Burden: The Global Campaign against Headache. J Headache Pain 2019; 20: 57.
[3]
Burch R, Rizzoli P, Loder E. The prevalence and impact of migraine and severe headache in the United States: Updated age, sex, and socioeconomic-specific estimates from government health surveys. Headache 2021; 61(1): 60-8.
[http://dx.doi.org/10.1111/head.14024] [PMID: 33349955]
[4]
Kurth T, Rist PM, Ridker PM, Kotler G, Bubes V, Buring JE. Association of migraine with aura and other risk factors with incident cardiovascular disease in women. JAMA 2020; 323(22): 2281-9.
[http://dx.doi.org/10.1001/jama.2020.7172] [PMID: 32515815]
[5]
Liampas I, Mylonas KS, Brotis A, et al. Serum lipid abnormalities in migraine: A meta-analysis of observational studies. Headache 2021; 61(1): 44-59.
[http://dx.doi.org/10.1111/head.14039] [PMID: 33398889]
[6]
Onderwater GLJ, Ligthart L, Bot M, et al. BBMRI Metabolomics Consortium. Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine. Neurology 2019; 92(16): e1899-911.
[http://dx.doi.org/10.1212/WNL.0000000000007313] [PMID: 30944236]
[7]
Pogoda JM, Gross NB, Arakaki X, Fonteh AN, Cowan RP, Harrington MG. Severe headache or migraine history is inversely correlated with dietary sodium intake: NHANES 1999-2004. Headache 2016; 56(4): 688-98.
[http://dx.doi.org/10.1111/head.12792] [PMID: 27016121]
[8]
Sánchez-Sellero I, San-Román-Rodríguez E, Santos-Pérez S, et al. Caffeine intake and Menière’s disease: Is there relationship? Nutr Neurosci 2017; 1-8.
[PMID: 28523982]
[9]
Kurth T, Ridker PM, Buring JE. Migraine and biomarkers of cardiovascular disease in women. Cephalalgia: an international journal of headache 2008; 28(1): 49-56.
[http://dx.doi.org/10.1111/j.1468-2982.2007.01467.x]
[10]
Gan WQ, Estus S, Smith JH. Association between overall and mentholated cigarette smoking with headache in a nationally representative sample. Headache 2016; 56(3): 511-8.
[http://dx.doi.org/10.1111/head.12778] [PMID: 26926358]
[11]
Rist PM, Tzourio C, Kurth T. Associations between lipid levels and migraine: cross-sectional analysis in the epidemiology of vascular ageing study. Cephalalgia 2011; 31(14): 1459-65.
[http://dx.doi.org/10.1177/0333102411421682] [PMID: 21926156]
[12]
Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS): National Health and Nutrition Examination Survey Questionnaire. Available from: http://www.cdc.gov/nchs/nhanes.htm [Accessed on: August 11, 2011
[13]
Ikeda K, Kawase Y, Takazawa T, Kano O, Tamura M, Iwasaki Y. Cardiovascular disease risk profile in Japanese midlife Migraineurs. J Neurol Res 2012; 2(1): 10-5.
[http://dx.doi.org/10.4021/jnr82w]
[14]
Zhuang Z, Gao M, Yang R, et al. Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: A Mendelian randomization analysis. Lipids Health Dis 2020; 19(1): 86.
[http://dx.doi.org/10.1186/s12944-020-01257-z] [PMID: 32384904]
[15]
Navab M, Anantharamaiah GM, Reddy ST, Van Lenten BJ, Fogelman AM. HDL as a biomarker, potential therapeutic target, and therapy. Diabetes 2009; 58: 2711-7.
[http://dx.doi.org/10.2337/db09-0538]

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