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Review Article

组蛋白去乙酰化酶及其抑制剂在结直肠癌治疗中的应用：当前的证据和未来的考虑

卷 29, 期 17, 2022

发表于: 10 January, 2022

页: [2979 - 2994] 页: 16

弟呕挨: 10.2174/0929867328666210915105929

价格: $65

摘要

结直肠癌（CRC）包括一组异质性胃肠道肿瘤。它是一种多因素疾病，其发病机制和病理生理学涉及许多不同的因素。CRC的发展不仅限于遗传变化，还涉及表观遗传和环境因素。在表观遗传因素中，组蛋白去乙酰化酶（HDAC）是一组调节基因表达的表观遗传酶，据报道在CRC中过度表达。HDACs及其抑制剂似乎在CRC的分子病理生理学中起重要作用。本综述的目的是确定HDAC抑制剂作为针对CRC的潜在抗癌药物的作用。

关键词: 组蛋白，脱乙酰酶，抑制剂，HDAC，HDACI，结直肠癌，靶向治疗，表观遗传学 。

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