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General Review Article

氟化姜黄素类似物的抗增殖潜力：实验和计算分析与文献走综述

卷 29, 期 8, 2022

发表于: 10 January, 2022

页: [1459 - 1471] 页: 13

弟呕挨: 10.2174/0929867328666210910141316

价格: $65

摘要

背景：食品中的姜黄素、调味剂和着色剂具有强大的抗氧化、抗肿瘤活性和抗炎作用。然而，它们会迅速代谢成活性较低的代谢物。因此，已经进行了各种研究以合成具有增强治疗活性的新的稳定的姜黄素类似物。 方法：通过氟苯甲醛（1a-1f）与姜黄素的Knoevenagel缩合合成含氟姜黄素化合物（2a-2f）。通过脱甲氧基姜黄素与 3,4-二氟苯甲醛 (1f) 的缩合合成氟化脱甲氧基姜黄素 (3a)。这些化合物的结构通过FTIR、1H-NMR、13C-NMR、19FNMR和质谱确认。使用 MTT 测定法评估了这些合成化合物对乳腺癌细胞 (4T1)、黑色素瘤癌细胞 (B16F10) 和正常细胞系 (NIH 3T3) 的抗增殖活性。研究了姜黄素、2f 和 3a 与几种蛋白质（1HCL、2ZOQ、3D94、5EW3、4WA9、1XKK、6CCY）的相互作用。通过分子动力学模拟研究表皮生长因子受体（EGFR）的结构保存。 结果：获得的光谱数据证实了所提出的氟化类似物的结构。结果表明，化合物2f和3a对癌细胞增殖的抑制作用明显优于其他化合物。化合物2f和3a与EGFR的亲和力最高，结合能最低。姜黄素、2f 和 3a 与 EGFR 的结合能分别为 -7.8、-10 和 -9.8 kcal/mol。分子对接结果表明化合物2f和3a与EGFR通过氢键的形成牢固地结合成复合物。 结论：综上所述，我们发现氟化脱甲氧基姜黄素和氟化姜黄素可诱导癌细胞死亡并以高亲和力与EGFR结合。

关键词: 姜黄素、去甲氧基姜黄素、肿瘤、乳腺癌、抗增殖、计算分析

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