An Overview on the Role of miR-451 in Lung Cancer: Diagnosis, Therapy, and Prognosis

Title:An Overview on the Role of miR-451 in Lung Cancer: Diagnosis, Therapy, and Prognosis

Volume: 10 Issue: 3

Author(s): Saiedeh Razi Soofiyani, Kamram Hosseini, Alireza Soleimanian, Liela Abkhooei, Akbar Mohammad Hoseini, Vahideh Tarhriz*Tohid Ghasemnejad*

Affiliation:

• Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran

• Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz,Iran

Keywords: miR-451, lung cancer, biomarker, cancer therapy, diagnosis, prognosis.

Abstract: MicroRNAs (miRNAs) are highly conserved non-coding RNAs involved in many physiological processes such as cell proliferation, inhibition, development of apoptosis, differentiation, suppression of tumorigenicity, and regulation of cell growth. The description of the alterations of miRNA expression patterns in cancers will be helpful in recognizing biomarkers for early detection and possible therapeutic intervention in the treatment of cancers. Recent studies have shown that miR-451 is broadly dysregulated in lung cancer and is a crucial agent in lung tumor progression. This review summarizes recent advances in the potential role of miR-451 in lung cancer diagnosis, prognosis, and treatment and provides an insight into the potential use of miR-451 for the development of advanced therapeutic methods in lung cancer.

Cite this article as:

Soofiyani Razi Saiedeh, Hosseini Kamram, Soleimanian Alireza, Abkhooei Liela, Hoseini Mohammad Akbar, Tarhriz Vahideh*, Ghasemnejad Tohid*, An Overview on the Role of miR-451 in Lung Cancer: Diagnosis, Therapy, and Prognosis, MicroRNA 2021; 10 (3) . https://dx.doi.org/10.2174/2211536610666210910130828