肠道微生物群与阿尔茨海默病:实验证据和临床现实

Title:Gut Microbiota and Alzheimer’s Disease: Experimental Evidence and Clinical Reality

Volume: 18 Issue: 10

关键词: 阿尔茨海默病，神经变性，肠道微生物群，肠脑轴，淀粉样前体蛋白，淀粉样β肽。

摘要: Alzheimer’s disease (AD) is characterized by progressive death of neuronal cells in the regions of the brain concerned with memory and cognition, and is the major cause of dementia in the elderly population. Various molecular mechanisms, metabolic risk factors and environmental triggers contributing to the genesis and progression of AD are under intense investigations. The present review has dealt with the impact of a highly discussed topic of gut microbiota affecting the neurodegeneration in the AD brain. A detailed description of the composition of gut bacterial flora and its interaction with the host has been presented, followed by an analysis of key concepts of bidirectional communication between gut microbiota and the brain. The substantial experimental evidence of gut microbiota affecting the neurodegenerative process in experimental AD models has been described next in this review, and finally, the limitations of such experimental studies vis-avis the actual disease and the paucity of clinical data on this topic have also been mentioned.

Cite this article as:

Gut Microbiota and Alzheimer’s Disease: Experimental Evidence and Clinical Reality, Current Alzheimer Research 2021; 18 (10) . https://dx.doi.org/10.2174/1567205018666210907160854