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Review Article

II型糖尿病慢性并发症的预防和管理：多酚的作用（小型综述）

卷 29, 期 6, 2022

发表于: 06 January, 2022

页: [1099 - 1109] 页: 11

弟呕挨: 10.2174/0929867328666210902131021

价格: $65

摘要

糖尿病的众多并发症可能至少部分是由与持续的高血糖状态相关的氧化应激产生的。多酚是基于植物的次级代谢产物，在预防和治疗某些疾病方面具有很高的潜力，特别是那些涉及氧化应激的疾病，例如糖尿病并发症。这篇叙述性综述的目的是展示多酚在治疗和预防这些并发症中的作用的主要证据。对于书目研究，考虑了截至 2021 年 3 月 15 日发表的论文，搜索词包括与多酚、它们的类别和一些与糖尿病并发症相关的更已知化合物相关的词。有许多研究表明多酚如何有效对抗糖尿病引起的内皮损伤、氧化应激和高炎症状态，这些是糖尿病并发症的起源。黄酮类化合物以及花青素、芪或木脂素等化合物可减缓肾损伤的进展，预防缺血性事件和糖尿病肾病。许多这些研究是临床前的，在细胞或动物模型中。多酚在防治糖尿病并发症中的作用无疑是大有可为的。然而，需要进行更多的临床试验来了解这些化合物的真正有效性。

关键词: 多酚、植物化学物质、氧化应激、糖尿病、类黄酮、花青素、芪。

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