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气道表面液体的低 pH 值和温度是增强 SARS-CoV-2 感染性的关键决定因素

卷 22, 期 6, 2022

发表于: 16 August, 2021

页: [471 - 477] 页: 7

弟呕挨: 10.2174/1566524021666210816095557

摘要

在临床前和临床水平上看到了压倒性的反应，以了解和对抗由严重急性呼吸综合征冠状病毒 2 [SARS-CoV-2] 引起的 2019 年冠状病毒病 [COVID-19] 大流行。 在诊断、治疗和预防措施方面取得了令人鼓舞的成功，包括疫苗开发。 事实上，SARS-CoV-2 的结构信息和帮助该病毒靶向 AEC 的分子步骤已被大量研究。 此外，在分子、遗传、表观遗传和微环境水平上广泛揭示了 COVID-19 的异质性和复杂性。 尽管在 COVID-19 发病机制方面取得了这些进展，但人们对 SARS-CoV-2 靶向感染 AEC 背后的原因知之甚少。 在这篇小型综述中，我们强调了气道表面液体 [ASL] 的 pH 值和温度作为可能有助于增强 SARS-CoV-2 靶向感染导致 COVID-19 的关键决定因素的作用。

关键词: 瘤形成、气道上皮细胞、细胞信号传导、COVID-19、低 pH 值、温度。

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