Bone Deleterious Effects of Different NRTIs in Treatment-naïve HIV Patients After 12 and 48 Weeks of Treatment

Title:Bone Deleterious Effects of Different NRTIs in Treatment-naïve HIV Patients After 12 and 48 Weeks of Treatment

Volume: 19 Issue: 5

Author(s): Patricia Atencio, Francisco Miguel Conesa-Buendía, Alfonso Cabello-Ubeda*, Patricia Llamas-Granda, Ramón Pérez-Tanoira, Laura Prieto-Pérez, Beatriz Álvarez Álvarez, Irene Carrillo Acosta, Rosa Arboiro-Pinel, Manuel Díaz-Curiel, Raquel Largo, Gabriel Herrero-Beaumont, Miguel Górgolas and Aránzazu Mediero

Affiliation:

• Division of Infectious Diseases, Fundacion Jimenez Díaz University Hospital, Research Health Institute, Autonoma de Madrid University (IIS-FJD, UAM). Madrid 28040,Spain

Keywords: HIV, tenofovir, abacavir, osteopenia, osteoporosis, bone markers.

Abstract:

Background: Bone alterations have been observed in the course of HIV infection, characterized by a marked decrease in bone mineral density (BMD) and an increase in the frequency of fractures as a result of fragility. We aim to evaluate early changes in bone metabolic profile and the possible association with tenofovir and other nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) in treatment-naïve HIV patients.

Methods: We conducted a prospective study in naïve HIV-infected adults (under 50 years), separated into three groups according to NRTI therapy: tenofovir disoproxil fumarate (TDF); tenofovir alafenamide (TAF) and abacavir (ABC). BMD and epidemiological, immunological and metabolic bone parameters were evaluated. Bone markers were analyzed in plasma at baseline, 12 and 48 weeks after initiating treatment.

Results: Average age of patients was 34.8 years (± 9.6). 92.4% of them with CD4 count > 200 cel/μL. At week 12 after starting treatment, both TDF [increase in PN1P (31.7%, p = 0.004), TRAP (11.1%, p = 0.003), OPN (19.3%, p = 0.045) and OC (38.6%, p = 0.001); decrease in OPG (-23.4%, p = 0.003)] and TAF [increase in 42.6% for CTX (p = 0.011), 27.3% for OC (p = 0.001) and 21% for TRAP (p = 0.008); decrease in OPG (-28.8%, p = 0.049)] presented a deep resorption profile compared to ABC, these differences in bone molecular markers, a tendency to equalize at week 48, where no significant differences were observed. Patients treated with TDF showed the greatest decrease in Z-score in both lumbar spine (LS) and femoral neck (FN) at week 48 without statistically significant differences.

Conclusion: Treatment-naïve HIV patients have a high prevalence of low bone density. Treatment with TDF is associated with greater bone deterioration at 12 and 48 weeks. TAF seems to present similar early bone deterioration at 12 weeks which disappears at 48 weeks.

Cite this article as:

Atencio Patricia , Conesa-Buendía Miguel Francisco , Cabello-Ubeda Alfonso *, Llamas-Granda Patricia , Pérez-Tanoira Ramón, Prieto-Pérez Laura , Álvarez Álvarez Beatriz , Acosta Carrillo Irene , Arboiro-Pinel Rosa , Díaz-Curiel Manuel , Largo Raquel, Herrero-Beaumont Gabriel , Górgolas Miguel and Mediero Aránzazu, Bone Deleterious Effects of Different NRTIs in Treatment-naïve HIV Patients After 12 and 48 Weeks of Treatment, Current HIV Research 2021; 19 (5) . https://dx.doi.org/10.2174/1570162X19666210805094434