Abstract
In the past few years, the number of protocols for α-amination of carbonyl compounds has dramatically increased, highlighting the importance of this moiety. While some classical approaches continue to be used, supported by novel catalysts, new methods with unique advantages have also emerged. Among these, a wide variety of conditions can be observed, such as the use of umpoled enolates with nucleophilic nitrogen sources, the generation of electrophilic nitrogen sources, and oxidative methods, generally through the generation of radical species. This review aims to compile the most recent publications for the α-amination of carbonyls on the basis of synthetic utility, novel transformations, and enantioselectivity.
Keywords: Amines, amination, chemoselectivity, enantioselectivity, catalysis, hypervalent compounds, synthetic methods.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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