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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Impact of ErbB Receptors and Anticancer Drugs against Breast Cancer: A Review

Author(s): Ankita Sahu, Saurabh Verma, Meena Varma and Manoj Kumar Yadav*

Volume 23, Issue 6, 2022

Published on: 19 July, 2021

Page: [787 - 802] Pages: 16

DOI: 10.2174/1389201022666210719161453

Price: $65

Abstract

Human EGFR (epidermal growth factor receptor) family of tyrosine kinase receptors consists of four members, ErbB1-4. Abnormalities in the ErbB family characterize a variety of human cancers, including breast cancer. Tyrosine kinase is recruited by the activated EGFR cell surface receptor, which transmitted signals from the receptor to interact with intracellular signaling pathways and regulate cellular functions and biological processes. Targeting the intracellular signaling pathways has been aided in the drug development that was already in use and more continually being developed. The review article highlights the function of ErbB receptors/ligands, their role in signaling pathways, effective targeted drugs, and a combination of targeted drug strategies in the treatment of breast cancer that could be leading to the novel combination of anticancer drug delivery systems.

Keywords: Breast cancer, ErbB receptors, ligands, signaling pathways, combinatorial drug, clinical trial.

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