Characterization and Prediction of Protein Interfaces to Infer Protein-Protein Interaction Networks

Title: Characterization and Prediction of Protein Interfaces to Infer Protein-Protein Interaction Networks

Volume: 9 Issue: 2

Author(s): Ozlem Keskin, Nurcan Tuncbag and Attila Gursoy

Affiliation:

Abstract: Complex protein-protein interaction networks govern biological processes in cells. Protein interfaces are the sites where proteins physically interact. Identification and characterization of protein interfaces will lead to understanding how proteins interact with each other and how they are involved in protein-protein interaction networks. What makes a given interface bind to different proteins; how similar/different the interactions in proteins are some key questions to be answered. Enormous amount of protein structures and experimental protein-protein interactions data necessitate advanced computational methods for analyzing and inferring new knowledge. Interface prediction methods use a wide range of sequence, structural and physico-chemical characteristics that distinguish interface residues from non-interface surface residues. Here, we present a review focusing on the characteristics of interfaces and the current status of interface prediction methods.

Cite this article as:

Keskin Ozlem, Tuncbag Nurcan and Gursoy Attila, Characterization and Prediction of Protein Interfaces to Infer Protein-Protein Interaction Networks, Current Pharmaceutical Biotechnology 2008; 9 (2) . https://dx.doi.org/10.2174/138920108783955191