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Review Article

糖化学中的芳香族相互作用：从分子识别到催化

卷 29, 期 7, 2022

发表于: 09 July, 2021

页: [1208 - 1218] 页: 11

弟呕挨: 10.2174/0929867328666210709120216

价格: $65

摘要

芳香平台是蛋白质碳水化合物结合域 (CBD)、RNA 受体和酶中普遍存在的识别基序。 它们通过参与堆积 CH/π 与相应吡喃糖单元的 α- 或 β- 面的相互作用来稳定糖苷/受体复合物。 此外，芳香单元在稳定糖苷阳离子过渡态中所起的作用近年来已开始得到认可。 在过去十年中进行的广泛研究允许剖析稳定碳水化合物/芳烃复合物的主要贡献力量，同时帮助描绘糖苷/芳烃化学结构之间的长期关系和这种相互作用的强度，以及它们的潜力 对糖苷反应性的影响。

关键词: 碳水化合物识别、堆叠 CH/π 相互作用、阳离子/π 相互作用、结构稳定性关系、糖苷键形成、碳水化合物结合域。

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