Abstract
The present review focuses on the synthesis of two heteroatoms containing sixmembered heterocyclic compounds, i.e., pyrimidine. In this review, a number of pyrimidine derivatives have been illustrated, which show the exceptional ability towards clinical practices. Pyrimidine derivatives show antimicrobial, antibacterial, antifungal, antiallergic, antiinflammatory, anticancer, and anticonvulsant activities. Therefore, researchers are encouraged to synthesize novel, potent, safe, and selective pyrimidine derivatives that are effective against the mutant strains, and the development of synthetic protocols is a high priority in medicinal chemistry research. Many methodologies have been developed for the preparation of pyrimidine derivatives. In this review article, the synthetic strategies of pyrimidine derivatives are classified into metal-catalyzed synthesis, ionic-liquid assisted synthesis, microwave-assisted synthesis, and solid-phase synthesis.
Keywords: Heterocycles, pyrimidine, nitrogen, metal, ionic-liquid, microwave, solid-phase.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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