Abstract
In the last few decades, urea derivatives have gained significant importance due to its wide applications in pharmaceutical, polymer, dyes, and agriculture industries. Urea derivatives are the key starting material for the synthesis of novel bioactive heterocyclic molecules. Substituted urea derivatives are known to possess a wide array of biological activities such as herbicidal, antimicrobial, antimalarial, antivirus, anticancer, antioxidants, antiproliferative, antiatherosclerotic, anti-inflammatory, antibiotic, sedatives, anticonvulsants and as HIV-1 protease inhibitor. Herein, the synthetic approach and its herbicidal, anticonvulsant, antimicrobial, and antiproliferative activities are reviewed. This review summarizes the current updates about the syntheses and biological behavior of substituted urea.
Keywords: Substituted urea, synthesis, biological activity, herbicidal activity, anticonvulsant activity, antimicrobial activity and antiproliferative activity.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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