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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Clinical Trial

Antihyperglycemic Effect of Fenugreek and Ginger in Patients with Type 2 Diabetes: A Double-Blind, Placebo-controlled Study

Author(s): Mohamed A. Elsaadany*, Hussah M. AlTwejry, Rwabi A. Zabran, Sara A. AlShuraim, Wala'a A. AlShaia, Omar I. Abuzaid and Waleed I. AlBaker

Volume 18, Issue 2, 2022

Published on: 06 January, 2022

Page: [231 - 237] Pages: 7

DOI: 10.2174/1573401317666210706121806

Price: $65

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a worldwide chronic, complex, and progressive disease that usually requires combination therapy for improved glycemic control. Although conventional medicine showed more potency than herbal medicine, a combination of both may result in better therapeutic outcomes with fewer side effects.

Objective: This study was conducted to investigate the antihyperglycemic potential of fenugreek seeds (Trigonellafoenum-graecum L.) and ginger root (Zingiber officinalis) in patients with T2DM along with their usual antidiabetic medications.

Methods: A double-blind, placebo-controlled study was conducted using 33 cases, who were randomly divided into three groups. The first group received oral placebo capsules (1 g 3 times a day) and served as a control group, while the other two groups each received capsules of either fenugreek or ginger powder of the same dosage (1 g 3 times a day). The study was conducted for 8 weeks and treatment effects in patients were assessed through the measurements of serum’s fasting blood sugar (FBS), HbA1c, lipid profile, as well as kidney and liver functions.

Results and Discussion: After 8 weeks of intervention, fenugreek and ginger induced a significant reduction in FBS by 19.1 ± 3.8% and 16.0 ± 8.0% compared to their baselines, respectively (p ≤ 0.05). Moreover, fenugreek significantly reduced HbA1c by 15.9 ± 4.9% compared to the baseline, while ginger did not. Creatinine and triglyceride levels were also reduced significantly (p ≤ 0.05) compared to their baselines in both fenugreek and ginger groups. However, all the other parameters did not significantly change.

Conclusion: This study provides evidence that using fenugreek and ginger may enhance glycemic control in T2DM patients. Additionally, they might improve kidney function and lipids profile.

Clinical Trial Registeration: The clinical trial has been registered with the number (2015-03‐229) at King Fahd University Hospital, Dammam, Saudi Arabia.

Keywords: Diabetes, fenugreek, ginger, double-blind, HbA1c, lipid profile, creatinine, trial registration.

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