Abstract
Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs’ residues are frequently found in the structures of smallmolecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.
Keywords: Tailor-made amino acids, blockbuster drugs, peptidomimetic, peptides, modern pharmaceuticals, drug design and development, asymmetric synthesis.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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