Recent Advances in Fe-MOF Compositions for Biomedical Applications

Title:Recent Advances in Fe-MOF Compositions for Biomedical Applications

Volume: 28 Issue: 30

Author(s): Yuyu Zhong, Weicong Liu, Congying Rao, Baohong Li, Xiaoxiong Wang*, Dong Liu, Ying Pan*Jianqiang Liu*

Affiliation:

• School of Civil and Environmental Engineering, Shenzhen Polytechnic, Shenzhen 518055,China

• Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808,China

• Dongguan Key Laboratory of Drug Design and Formulation Technology, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan 523808,China

Keywords: MOF, Fe-based MOF, biomedical applications, DDS, MIL, cancer.

Abstract:

Background: To date, number of new and attractive materials have been applied in drug delivery systems (DDDs) to improve the efficiency of the treatment of cancers. Some problems like low stability, toxicity and weak ability of targeting have hampered most of materials for further applications in biomedicine. MIL(MIL = Materials of Institute Lavoisier), as a specific subclass of metal-organic frameworks (MOFs) owns more advantages than other subclass MOFs, such as better biodegradability and lower cytotoxicity. However, until now, systematic -s and analyses of Fe-based MIL on medical applications are rarely though the majority of documents discussed one research branch of the porous materials MOFs.

Discussion: In this review, we have focussed mainly on the latest studies of applications, including bioimaging, biosensing, and antibacterial and drug delivery on Fe-based MIL. The existing shortcomings and future perspectives of the rapidly growing biomedical applications of Fe-based MIL materials addressing dosage and loading strategies issues are also discussed briefly, and further studies with the use of different therapies will be of great interest.

Conclusion: This article reviews the Fe-based MOFs design and biomedical application, including biosensing, bioimaging, antibacterial agent, and drug delivery in recent years.

Cite this article as:

Zhong Yuyu , Liu Weicong , Rao Congying , Li Baohong , Wang Xiaoxiong *, Liu Dong , Pan Ying *, Liu Jianqiang *, Recent Advances in Fe-MOF Compositions for Biomedical Applications, Current Medicinal Chemistry 2021; 28 (30) . https://dx.doi.org/10.2174/0929867328666210511014129