Chronic Immune Activation Among Treatment Naïve HIV/ HBV Coinfected Individuals From Southern India

Title:Chronic Immune Activation Among Treatment Naïve HIV/ HBV Coinfected Individuals From Southern India

Volume: 19 Issue: 4

Author(s): John Paul Demosthenes, Gnanadurai John Fletcher, Uday George Zachariah, George Mannil Varghese, Susanne Alexander Pulimood, Priya Abraham and Rajesh Kannangai*

Affiliation:

• Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, 632004,India

Keywords: HIV, HBV, HIV/HBV coinfection, chronic immune activation, liver disease, CD38 and HLA-DR.

Abstract:

Background: Chronic immune activation is one of the most widely recognized hallmarks of HIV infection. T-cells that express CD38+ and HLA-DR+ show poor proliferative potential, signal transduction, and increased apoptotic potential. This affects HIV pathogenesis and its outcome and further complicates with a coinfection like HBV.

Methods: Study Design: cross-sectional. Blood samples were collected and analyzed for virological markers using ELISA for HBeAg and RT-PCR for HIV&HBV Viral load. Chronic immune activation markers of CD8+ and CD4+ T cells were measured by Flow cytometry for both HIV and HBV.

Results: There was a significant increase in HBV replication shown by higher HBV DNA (p=0.002), a higher proportion of HBeAg (p=0.0049), and lower CD4 counts (p=0.04) among HIV/HBV coinfected individuals, compared to the monoinfected groups. The frequencies of CD4+ CD38+ HLA-DR+ and CD8+ CD38+ HLA-DR+ in the HIV/HBV coinfection were significantly higher than HBV monoinfected group (P< 0.0001) and in the HIV monoinfected group (P < 0.0001). The Liver fibrosis score APRI and FIB-4, were higher in the coinfected group compared with HBV monoinfected group (0.67 vs. 0.25, p = 0.0085; 3.48 vs. 0.98, p = 0.0026) respectively. The cytokine levels of IL-17, Fas-L,TNF -α, IL-10, IL-2 and Granzyme B were also measured and compared among the study groups.

Conclusion: Our data suggest that HIV probably influences immune activation of CD4+ and CD8+ T cells and this may play a significant role in accelerating the disease outcome among HIV/HBV coinfected individuals.

Cite this article as:

Demosthenes Paul John , Fletcher John Gnanadurai, Zachariah George Uday , Varghese Mannil George , Pulimood Alexander Susanne , Abraham Priya and Kannangai Rajesh *, Chronic Immune Activation Among Treatment Naïve HIV/ HBV Coinfected Individuals From Southern India, Current HIV Research 2021; 19 (4) . https://dx.doi.org/10.2174/1570162X19666210506160642