Synthesis of N,N'-Diacylhydrazines and their Use in Various Synthetic Transformations

Title:Synthesis of N,N'-Diacylhydrazines and their Use in Various Synthetic Transformations

Volume: 25 Issue: 12

Author(s): Mohammed A. Baashen*

Affiliation:

• Department of Chemistry, College of Science and Humanities, Shaqra University, Dawadmi 11911,Saudi Arabia

Keywords: N, N`-Diacylhydrazines, insecticides, heterocycles, 1, 3, 4-oxadiazoles, 1, 3, 4-thiadiazoles, 1, 2, 4-triazoles.

Abstract:

Background: N,N'-Diacylhydrazines are involved in many synthetic transformations. The current work reviews the synthesis of N,N'-diacylhydrazines and their use in various synthetic transformations.

Results: Three synthetic routes are commonly used to produce N,N'-diacylhydrazines. They are produced through the coupling of acyl chlorides and carbohydrazides, the reaction of hydrazine hydrate and carboxylic acids or isocyanates, and the dimerization of carbohydrazides. They can be oxidized to produce the corresponding esters and act as precursors in the synthesis of various heterocycles such as 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles, pyrazoles, tetrazines, and crown ethers.

Conclusions: Various synthetic procedures have been reported for the production of N,N'- diacylhydrazines. N,N'-Diacylhydrazines are involved in the synthesis of various heterocycles.

Cite this article as:

Baashen A. Mohammed *, Synthesis of N,N'-Diacylhydrazines and their Use in Various Synthetic Transformations, Current Organic Chemistry 2021; 25 (12) . https://dx.doi.org/10.2174/1385272825666210505105032