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Mini-Review Article

Review of 10,11-Dehydrocurvularin: Synthesis, Structural Diversity, Bioactivities and Mechanisms

Author(s): FuGui Zhou, Yiqing Zhou , ZhiYong Guo , XianJun Yu and Zhangshuang Deng *

Volume 22, Issue 6, 2022

Published on: 13 January, 2022

Page: [836 - 847] Pages: 12

DOI: 10.2174/1389557521666210428132256

Price: $65

Abstract

10,11-Dehydrocurvularin is a natural benzenediol lactone (BDL) with a 12-membered macrolide fused to a resorcinol ring produced as a secondary metabolite by many fungi. In this review, we summarized the pieces of literature regarding biosynthesis, chemical synthesis, biological activities, and assumed work mechanisms of 10,11-dehydrocurvularin, which presented a potential for agricultural and pharmaceutical uses.

Keywords: 10, 11-Dehydrocurvularin, bioactivity, antitumor, structure-activity-relationship, target, benzenediol lactone (BDL).

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