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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Author(s): Andrew Li, Clifford Pereira, Elise Eleanor Hill, Olivia Vukcevich and Aijun Wang *

Volume 20, Issue 2, 2022

Published on: 07 February, 2022

Page: [344 - 361] Pages: 18

DOI: 10.2174/1570159X19666210407155543

Price: $65

Abstract

Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.

Keywords: Ex vivo models, in vitro models, in vivo models, organotypic models, peripheral nerve, peripheral nerve injury, peripheral nerve regeneration.

Graphical Abstract

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