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Current Drug Research Reviews

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ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

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Case Report

Phenytoin induced Stevens-Johnson Syndrome-toxic Epidermal Necrolysis Overlap Exacerbated by Cephalexin in a 65-Year-old Neurosurgical Patient: A Rare Case Report

Author(s): Kiran Kumar Rathinam, Sarvesh Sabarathinam, Poojith Nuthalapati and Vijayakumar Thangavel Mahalingam*

Volume 14, Issue 1, 2022

Published on: 22 March, 2021

Page: [80 - 83] Pages: 4

DOI: 10.2174/2589977513666210322160009

Price: $65

Abstract

Objective: To report a rare case of drug induced overlap of Stevens-Johnson syndrome and Toxic Epidermal Necrosis Syndrome exacerbated by cephalexin.

Case Presentation: In this case report, we present a 65-year-old female who had come to the hospital with complaints of Sloughing of the skin and redness all over the body with raised body temperature. She was on therapeutic Phenytoin to prevent the post-surgical complications of Communicating Hydrocephalus. After a detailed examination, it was found that the patient had misemployed with an overdose of Phenytoin. The patient was found with nikolsky sign and diagnosed as Stevens- Johnson syndrome and Toxic Epidermal Necrosis overlap. This case report emphasizes phenytoin induced Stevens-Johnson syndrome and Toxic Epidermal Necrosis syndrome exacerbated by cephalexin.

Conclusion: By witnessing this phenomenon, we could figure out the association between cephalexin and Stevens-Johnson syndrome- Toxic Epidermal Necrosis syndrome overlap. The Immediate dismissal of the offending agent and commencement of supportive care was found to be effective.

Keywords: Phenytoin, Stevens-Johnson syndrome, toxic epidermal necrolysis, neurosurgery, cephalexin, adverse drug reaction.

« Previous
[1]
Jadhav P, Rogers JE, Shroff R. A Case Report-Stevens-Johnson Syndrome as an Adverse Effect of Capecitabine. J Gastrointest Cancer 2018; 49(3): 349-50.
[http://dx.doi.org/10.1007/s12029-016-9916-3] [PMID: 28066869]
[2]
Sethuraman G, Sharma VK, Pahwa P, Khetan P. Causative Drugs and Clinical Outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN Overlap in Children. Indian J Dermatol 2012; 57(3): 199-200.
[http://dx.doi.org/10.4103/0019-5154.96192] [PMID: 22707771]
[3]
Su S-C, Chung W-H. Update on Pathobiology in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Zhonghua Pifuke Yixue Zazhi 2013; 31(4): 175-80.
[http://dx.doi.org/10.1016/j.dsi.2013.09.002]
[4]
French LE. Toxic epidermal necrolysis and Stevens Johnson syndrome: our current understanding. Allergol Int 2006; 55(1): 9-16.
[http://dx.doi.org/10.2332/allergolint.55.9] [PMID: 17075281]
[5]
Letko E, Papaliodis DN, Papaliodis GN, Daoud YJ, Ahmed AR, Foster CS. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature. Ann Allergy Asthma Immunol 2005; 94(4): 419-36.
[http://dx.doi.org/10.1016/S1081-1206(10)61112-X] [PMID: 15875523]
[6]
Marco-Del Río J, Domingo-Chiva E, Cuesta-Montero P, Valladolid-Walsh A, García-Martínez EM. Cefepime Associated With Phenytoin Induced Stevens-Johnson Syndrome. Am J Ther 2017; 24(4): e481-4.
[http://dx.doi.org/10.1097/MJT.0000000000000520] [PMID: 28692440]
[7]
Dodiuk-Gad RP, Chung WH, Valeyrie-Allanore L, Shear NH. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Update. Am J Clin Dermatol 2015; 16(6): 475-93.
[http://dx.doi.org/10.1007/s40257-015-0158-0] [PMID: 26481651]
[8]
Petri WA Jr. Penicillinscephalosporins and other β-lactam antibiotics.Goodman and Gilman's Pharmacological Basis of Therapeutics. 12th ed.. China: McGraw Hill Medical 2011.
[9]
Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30(2): 239-45.
[http://dx.doi.org/10.1038/clpt.1981.154] [PMID: 7249508]
[10]
S P, K M, S A. Causality, severity and preventability assessment of adverse cutaneous drug reaction: a prospective observational study in a tertiary care hospital. J Clin Diagn Res 2013; 7(12): 2765-7.
[http://dx.doi.org/10.7860/JCDR/2013/7430.3753] [PMID: 24551632]
[11]
Zaki SA. Adverse drug reaction and causality assessment scales. Lung India 2011; 28(2): 152-3.
[http://dx.doi.org/10.4103/0970-2113.80343] [PMID: 21712934]
[12]
Sabourirad S, Mortezaee R, Mojarad M, et al. Investigating the association of Lamotrigine and Phenytoin-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis with HLA-B*1502 in Iranian population. Exp Dermatol 2020.
[http://dx.doi.org/10.1111/exd.14240] [PMID: 33217035]

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