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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

癌症干细胞异常脂质代谢在癌症进展中的作用

卷 21, 期 8, 2021

发表于: 16 March, 2021

页: [631 - 639] 页: 9

弟呕挨: 10.2174/1568009619666210316112333

价格: $65

摘要

癌症干细胞 (CSC) 代表一小群能够自我更新和引发肿瘤的癌细胞，它们经历表观遗传、上皮间充质、免疫和代谢重编程以适应肿瘤微环境并在宿主防御或 治疗性侮辱。 众所周知，伴随癌症发作的代谢重编程对于疾病的发病机制至关重要。 在几乎所有癌症类型中都观察到脂质代谢的协调失调。 除了满足膜合成结构脂质的基本要求外，脂质还起着重要的信号分子的作用，并有助于能量稳态。 在这篇综述中，我们总结了癌症进展中 CSC 异常脂质代谢这一有吸引力的研究领域的当前进展，这为基于 CSC 调节脂质代谢的治疗药物提供了见解。

关键词: 癌症干细胞 (CSC)、脂质代谢、癌症进展、肿瘤微环境、脂质代谢失调、能量稳态。

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