摘要
饮食在确保健康生活方面发挥着重要作用,食品和药用植物中存在的生物活性化合物可能被开发为对抗各种疾病的药物。 一种具有生物活性的黄酮类化合物槲皮素是一种膳食成分,具有许多促进健康的作用。 在类风湿性关节炎、痛风性关节炎和骨关节炎的临床前模型中,槲皮素已显示出显着的关节保护作用。 考虑到这种化合物的重要性,本综述讨论了它的抗关节炎特性,证明了其治疗关节炎的作用机制及其治疗潜力。
关键词: 槲皮素、关节炎、生物活性化合物、类黄酮、植物化学物质、关节痛。
[1]
Borghi SM, Mizokami SS, Pinho-Ribeiro FA, et al. The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice. J Nutr Biochem 2018; 53: 81-95.
[http://dx.doi.org/10.1016/j.jnutbio.2017.10.010] [PMID: 29197723]
[http://dx.doi.org/10.1016/j.jnutbio.2017.10.010] [PMID: 29197723]
[2]
Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: A bioactive flavonoid Pharmacogn Rev 2016; 10(20): 84-9. http://www.phcogrev.com/article/2016/10/20/1041030973-7847194044 [Internet].
[http://dx.doi.org/10.4103/0973-7847.194044] [PMID: 28082789]
[http://dx.doi.org/10.4103/0973-7847.194044] [PMID: 28082789]
[3]
Bastaminejad S, Bakhtiyari S. Quercetin and its relative therapeutic potential against COVID-19: A retrospective review and prospective overview 2021 21(5): 385-391. https://www.eurekaselect.com/186085/article[Internet]
[http://dx.doi.org/10.2174/1566524020999200918150630] [PMID: 32957884]
[http://dx.doi.org/10.2174/1566524020999200918150630] [PMID: 32957884]
[4]
Cimanga K, Ying L, De Bruyne T, et al. Radical scavenging and xanthine oxidase inhibitory activity of phenolic compounds from Bridelia ferruginea stem bark. J Pharm Pharmacol 2001; 53(5): 757-61.
[http://dx.doi.org/10.1211/0022357011775893] [PMID: 11370716]
[http://dx.doi.org/10.1211/0022357011775893] [PMID: 11370716]
[5]
Gründemann C, Gruber CW, Hertrampf A, Zehl M, Kopp B, Huber R. An aqueous birch leaf extract of Betula pendula inhibits the growth and cell division of inflammatory lymphocytes. J Ethnopharmacol 2011; 136(3): 444-51. https://linkinghub.elsevier.com/retrieve/pii/S0378874111003540 [Internet]
[http://dx.doi.org/10.1016/j.jep.2011.05.018] [PMID: 21619918]
[http://dx.doi.org/10.1016/j.jep.2011.05.018] [PMID: 21619918]
[6]
Yang Y, Yu T, Jang H-J, et al. In vitro and in vivo antiinflammatory activities of Polygonum hydropiper methanol extract. J Ethnopharmacol 2012; 139(2): 616-25. https://linkinghub.elsevier.com/retrieve/pii/S0378874111008701 [Internet].
[http://dx.doi.org/10.1016/j.jep.2011.12.003] [PMID: 22182430]
[http://dx.doi.org/10.1016/j.jep.2011.12.003] [PMID: 22182430]
[7]
Wei B, Zhang Y, Tang L, Ji Y, Yan C, Zhang X. Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis Drug Dev Res 2019; 80(3): 360-7. https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.21510
[http://dx.doi.org/10.1002/ddr.21510] [PMID: 30609097]
[http://dx.doi.org/10.1002/ddr.21510] [PMID: 30609097]
[8]
Almeida AF, Borge GIA, Piskula M, et al. Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation. Compr Rev Food Sci Food Saf 2018; 17(3): 714-731 [Internet].
[http://dx.doi.org/10.1111/1541-4337.12342] [PMID: 33350133]
[http://dx.doi.org/10.1111/1541-4337.12342] [PMID: 33350133]
[9]
Saccol RDSP, da Silveira KL, Manzoni AG, et al. Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis. J Cell Biochem 2020; 121(4): 2792-801. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.29502 [Internet].
[http://dx.doi.org/10.1002/jcb.29502] [PMID: 31691375]
[http://dx.doi.org/10.1002/jcb.29502] [PMID: 31691375]
[10]
Saccol RDSP, da Silveira KL, Adefegha SA, et al. Effect of quercetin on E-NTPDase/E-ADA activities and cytokine secretion of complete Freund adjuvant-induced arthritic rats. Cell Biochem Funct 2019; 37(7): 474-85. https://onlinelibrary.wiley.com/doi/abs/10.1002/cbf.3413 [Internet].
[http://dx.doi.org/10.1002/cbf.3413] [PMID: 31365139]
[http://dx.doi.org/10.1002/cbf.3413] [PMID: 31365139]
[11]
Yang Y, Zhang X, Xu M, Wu X, Zhao F, Zhao C. Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1- mediated anti-inflammatory effect. Int Immunopharmacol 2018 Jan; 54(June 2017): 153-162.. Available from:
[http://dx.doi.org/10.1016/j.intimp.2017.11.013]
[http://dx.doi.org/10.1016/j.intimp.2017.11.013]
[12]
Xiao P, Hao Y, Zhu X, Wu X. p53 contributes to quercetininduced apoptosis in human rheumatoid arthritis fibroblastlike synoviocytes. Inflammation 2013; 36(2): 272-8 http://link.springer.com/10.1007/s10753-012-9543-5 [Internet].
[http://dx.doi.org/10.1007/s10753-012-9543-5] [PMID: 22983795]
[http://dx.doi.org/10.1007/s10753-012-9543-5] [PMID: 22983795]
[13]
Pan F, Zhu L, Lv H, Pei C. Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1 Int J Mol Med 2016; 38(5): 1507-14 https://www.spandidos-publications.com/10.3892/ijmm.2016.2755 [Internet].
[http://dx.doi.org/10.3892/ijmm.2016.2755] [PMID: 28026003]
[http://dx.doi.org/10.3892/ijmm.2016.2755] [PMID: 28026003]
[14]
Zhao J, Chen B, Peng X, et al. Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis. Immunopharmacol Immunotoxicol 2020; 42(3): 221-7.
[http://dx.doi.org/10.1080/08923973.2020.1742732] [PMID: 32216502]
[http://dx.doi.org/10.1080/08923973.2020.1742732] [PMID: 32216502]
[15]
Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study Ann Rheum Dis 2014; 73(7): 1323-30 https://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-204763 [Internet].
[http://dx.doi.org/10.1136/annrheumdis-2013-204763] [PMID: 24553908]
[http://dx.doi.org/10.1136/annrheumdis-2013-204763] [PMID: 24553908]
[16]
Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y. Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free Radic Biol Med 2019; 145(September): 146-60.
[http://dx.doi.org/10.1016/j.freeradbiomed.2019.09.024] [PMID: 31550528]
[http://dx.doi.org/10.1016/j.freeradbiomed.2019.09.024] [PMID: 31550528]
[17]
Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis Curr Opin Rheumatol 2010; 22(2): 139-43 http://journals.lww.com/00002281-201003000-00006 [Internet].
[http://dx.doi.org/10.1097/BOR.0b013e3283367a6e] [PMID: 20090528]
[http://dx.doi.org/10.1097/BOR.0b013e3283367a6e] [PMID: 20090528]
[18]
Qiu L, Luo Y, Chen X. Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats. Biomed Pharmacother 2018; 103(January): 1585-91.
[http://dx.doi.org/10.1016/j.biopha.2018.05.003] [PMID: 29864946]
[http://dx.doi.org/10.1016/j.biopha.2018.05.003] [PMID: 29864946]
[19]
Matsuno H, Nakamura H, Katayama K, et al. Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis Biosci Biotechnol Biochem 2009; 73(2): 288-92 http://www.tandfonline.com/doi/full/10.1271/bbb.80418 [Internet].
[http://dx.doi.org/10.1271/bbb.80418] [PMID: 19202302]
[http://dx.doi.org/10.1271/bbb.80418] [PMID: 19202302]
[20]
Gentle MJ. Sodium urate arthritis: effects on the sensory properties of articular afferents in the chicken Pain 1997; 70(2-3): 245-51 http://journals.lww.com/00006396-199704000-00019 [Internet].
[http://dx.doi.org/10.1016/S0304-3959(97)03324-6] [PMID: 9150300]
[http://dx.doi.org/10.1016/S0304-3959(97)03324-6] [PMID: 9150300]
[21]
di Giovine FS, Malawista SE, Thornton E, Duff GW. Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells Cytokine mRNA and protein kinetics, and cellular distribution J Clin Invest 1991; 87(4): 1375-81 http://www.jci.org/articles/view/115142[Internet].
[http://dx.doi.org/10.1172/JCI115142] [PMID: 2010550]
[http://dx.doi.org/10.1172/JCI115142] [PMID: 2010550]
[22]
Falasca G. Natalie Dubchak. New and improved strategies for the treatment of gout. Int J Nephrol Renovasc Dis 2010; 3: 145-66.www.dovepress.com/new-and-improved-strategies-for-the-treatment-of-gout-peer-reviewed-article-IJNRD[Internet].
[23]
Huang J, Zhu M, Tao Y, et al. Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. J Pharm Pharmacol 2012; 64(8): 1119-1127 [Internet].
[http://dx.doi.org/10.1111/j.2042-7158.2012.01504.x] [PMID: 22775215]
[http://dx.doi.org/10.1111/j.2042-7158.2012.01504.x] [PMID: 22775215]
[24]
Shi Y, Williamson G. Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial Br J Nutr 2016; 115(5): 800-6 https://www.cambridge.org/core/product/identifier/S0007114515005310/type/journal_article [Internet].
[http://dx.doi.org/10.1017/S0007114515005310] [PMID: 26785820]
[http://dx.doi.org/10.1017/S0007114515005310] [PMID: 26785820]
[25]
Ruiz-Miyazawa KW, Staurengo-Ferrari L, Mizokami SS, et al. Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome Inflammopharmacology 2017; 25(5): 555-70 http://link.springer.com/10.1007/s10787-017-0356-x [Internet].
[http://dx.doi.org/10.1007/s10787-017-0356-x] [PMID: 28508104]
[http://dx.doi.org/10.1007/s10787-017-0356-x] [PMID: 28508104]
[26]
Haleagrahara N, Miranda-Hernandez S, Alim MA, Hayes L, Bird G, Ketheesan N. Therapeutic effect of quercetin in collagen-induced arthritis. Biomed Pharmacother 2017; 90: 38-46.
[http://dx.doi.org/10.1016/j.biopha.2017.03.026] [PMID: 28342364]
[http://dx.doi.org/10.1016/j.biopha.2017.03.026] [PMID: 28342364]
[27]
Guazelli CFS, Staurengo-Ferrari L, Zarpelon AC, Pinho-Ribeiro FA, Ruiz-Miyazawa KW, Vicentini FTMC, et al. Quercetin attenuates zymosan-induced arthritis in mice. Biomed Pharmacother 2018; 102: 175-184 Available from:.
[http://dx.doi.org/10.1016/j.biopha.2018.03.057]]
[http://dx.doi.org/10.1016/j.biopha.2018.03.057]]
[28]
Kim H-R, Kim B-M, Won JY, et al. Quercetin, a Plant Polyphenol, Has Potential for the Prevention of Bone Destruction in Rheumatoid Arthritis. J Med Food 2019; 22(2): 152-61. https://www.liebertpub.com/doi/10.1089/jmf.2018.4259 [Internet].
[http://dx.doi.org/10.1089/jmf.2018.4259] [PMID: 30596535]
[http://dx.doi.org/10.1089/jmf.2018.4259] [PMID: 30596535]
[29]
Piovezana Bossolani GD, Silva BT, Colombo Martins Perles JV, et al. Rheumatoid arthritis induces enteric neurodegeneration and jejunal inflammation, and quercetin promotes neuroprotective and anti-inflammatory actions. Life Sci 2019; 238: 116956.
[http://dx.doi.org/10.1016/j.lfs.2019.116956] [PMID: 31622607]
[http://dx.doi.org/10.1016/j.lfs.2019.116956] [PMID: 31622607]
[30]
Haleagrahara N, Hodgson K, Miranda-Hernandez S, Hughes S, Kulur AB, Ketheesan N. Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis. Inflammopharmacology 2018; 26(5): 1219-32.
[http://dx.doi.org/10.1007/s10787-018-0464-2] [PMID: 29616452]
[http://dx.doi.org/10.1007/s10787-018-0464-2] [PMID: 29616452]
[31]
Gardi C, Bauerova K, Stringa B, et al. Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis Arch Biochem Biophys 2015; 583: 150-7 https://linkinghub.elsevier.com/retrieve/pii/S0003986115300345 [Internet].
[http://dx.doi.org/10.1016/j.abb.2015.08.008] [PMID: 26297952]
[http://dx.doi.org/10.1016/j.abb.2015.08.008] [PMID: 26297952]
[32]
Britti D, Crupi R, Impellizzeri D, et al. A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models BMC Vet Res 2017; 13(1): 229 http://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-1151-z [Internet].
[http://dx.doi.org/10.1186/s12917-017-1151-z] [PMID: 28768536]
[http://dx.doi.org/10.1186/s12917-017-1151-z] [PMID: 28768536]
[33]
Natarajan V, Krithica N, Madhan B, Sehgal PK. Formulation and evaluation of quercetin polycaprolactone microspheres for the treatment of rheumatoid arthritis. J Pharm Sci 2011; 100(1):195-205. https://linkinghub.elsevier.com/retrieve/pii/S0022354915323455 [Internet].
[http://dx.doi.org/10.1002/jps.22266] [PMID: 20607810]
[http://dx.doi.org/10.1002/jps.22266] [PMID: 20607810]
[34]
Choi EJ, Bae SC, Yu R, Youn J, Sung MK. Dietary vitamin E and quercetin modulate inflammatory responses of collagen-induced arthritis in mice. J Med Food 2009; 12(4): 770-5.
[http://dx.doi.org/10.1089/jmf.2008.1246] [PMID: 19735175]
[http://dx.doi.org/10.1089/jmf.2008.1246] [PMID: 19735175]
[35]
Jackson JK, Higo T, Hunter WL, Burt HM. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis Inflamm Res 2006; 55(4): 168-75 http://link.springer.com/10.1007/s00011-006-0067-z [Internet].
[http://dx.doi.org/10.1007/s00011-006-0067-z] [PMID: 16807698]
[http://dx.doi.org/10.1007/s00011-006-0067-z] [PMID: 16807698]
[36]
Kawaguchi K, Kaneko M, Miyake R, Takimoto H, Kumazawa Y. Potent Inhibitory Effects of Quercetin on Inflammatory Responses of Collagen-Induced Arthritis in Mice Endocr Metab Immune Disord Drug Targets 2019; 19(3): 308-15 http://www.eurekaselect.com/169723/article [Internet].
[http://dx.doi.org/10.2174/1871530319666190206225034] [PMID: 30727927]
[http://dx.doi.org/10.2174/1871530319666190206225034] [PMID: 30727927]
[37]
Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco 2001; 56(9): 683-7.
[http://dx.doi.org/10.1016/S0014-827X(01)01111-9] [PMID: 11680812]
[http://dx.doi.org/10.1016/S0014-827X(01)01111-9] [PMID: 11680812]
[38]
Mamani-Matsuda M, Kauss T, Al-Kharrat A, et al. Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators Biochem Pharmacol 2006; 72(10): 1304-10 https://linkinghub.elsevier.com/retrieve/pii/S0006295206004965 [Internet].
[http://dx.doi.org/10.1016/j.bcp.2006.08.001] [PMID: 16959220]
[http://dx.doi.org/10.1016/j.bcp.2006.08.001] [PMID: 16959220]
[39]
Santos EOL, Kabeya LM, Figueiredo-Rinhel ASG, et al. Flavonols modulate the effector functions of healthy individuals’ immune complex-stimulated neutrophils: a therapeutic perspective for rheumatoid arthritis. Int Immunopharmacol 2014; 21(1): 102-11.
[http://dx.doi.org/10.1016/j.intimp.2014.04.014] [PMID: 24797916]
[http://dx.doi.org/10.1016/j.intimp.2014.04.014] [PMID: 24797916]
[40]
Sung MS, Lee E-G, Jeon HS, et al. Quercetin inhibits IL-1β- induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation 2012; 35(4): 1585-94. http://link.springer.com/10.1007/s10753-012-9473-2 [Internet].
[http://dx.doi.org/10.1007/s10753-012-9473-2] [PMID: 22592909]
[http://dx.doi.org/10.1007/s10753-012-9473-2] [PMID: 22592909]
[41]
Javadi F, Ahmadzadeh A, Eghtesadi S, et al. The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial. J Am Coll Nutr 2017; 36(1): 9- 15. https://www.tandfonline.com/doi/full/10.1080/07315724.2016.1140093 [Internet].
[http://dx.doi.org/10.1080/07315724.2016.1140093] [PMID: 27710596]
[http://dx.doi.org/10.1080/07315724.2016.1140093] [PMID: 27710596]
[42]
Gokhale JP, Mahajan HS, Surana SJ. Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: In vivo and in vitro studies. Biomed Pharmacother 2019; 112(7): 108622 Available from:.
[http://dx.doi.org/10.1016/j.biopha.2019.108622]
[http://dx.doi.org/10.1016/j.biopha.2019.108622]
[43]
Ansari MM. Neha, Khan HA. Quercetin alleviate oxidative stress and inflammation through upregulation of antioxidant machinery and down-regulation of COX2 and NF-κB expression in collagen induced rheumatoid arthritis. Int J Drug Dev Res 2014; 6(1): 215-30.
[44]
Yuan K, Zhu Q, Lu Q, et al. Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities. J Nutr Biochem 2020; 84: 108454. https://linkinghub.elsevier.com/retrieve/pii/S0955286320304861 [Internet].
[http://dx.doi.org/10.1016/j.jnutbio.2020.108454] [PMID: 32679549]
[http://dx.doi.org/10.1016/j.jnutbio.2020.108454] [PMID: 32679549]
[45]
Zhang J, Yin J, Zhao D, et al. Therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis. J Int Med Res 2020; 48(3): 300060519873461. http://journals.sagepub.com/doi/10.1177/0300060519873461 [Internet].
[http://dx.doi.org/10.1177/0300060519873461] [PMID: 31842639]
[http://dx.doi.org/10.1177/0300060519873461] [PMID: 31842639]
[46]
Chen G, Ye Y, Cheng M, et al. Quercetin Combined With Human Umbilical Cord Mesenchymal Stem Cells Regulated Tumour Necrosis Factor-α/Interferon-γ-Stimulated Peripheral Blood Mononuclear Cells via Activation of Toll-Like Receptor 3 Signalling. Front Pharmacol 2020; 11(4): 499.
[http://dx.doi.org/10.3389/fphar.2020.00499] [PMID: 32390844]
[http://dx.doi.org/10.3389/fphar.2020.00499] [PMID: 32390844]