Abstract
The selective introduction or manipulation of side chains in a peptide represents a severe synthetic challenge. During the last years numerous different approaches towards the targeted modification of small to medium-sized peptides have been developed which should be presented in this review. Focusing on the manipulation of the peptide backbone, procedures concerning selective N-alkylation, C-alkylation and Cequals;O-thionation are described.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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