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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

阿尔茨海默氏病及其相关的痴呆类型：通过基于纳米技术的治疗策略进行的治疗回顾

卷 17, 期 14, 2020

页: [1239 - 1261] 页: 23

弟呕挨: 10.2174/1567205018666210218160812

价格: $65

摘要

背景：痴呆症及其相关类型，例如阿尔茨海默氏病，血管性痴呆和混合性痴呆属于脑相关疾病，导致长期进行性记忆丧失。这些疾病非常严重，可能会影响一个人的日常生活。迄今为止，由于痴呆症的复杂病理生理学和缺乏有效的药理学方法，痴呆症的治疗仍然是一个尚未得到解决的挑战。基于纳米技术的药物产品的使用可能会改善痴呆症的管理，因为纳米载体可以更有效地将药物输送到大脑。 目的：本研究的目的是提供当前基于纳米技术的药物输送系统，用于治疗各种类型的痴呆症。另外，正在讨论针对所述痴呆类型的当前诊断生物标志物以及它们可用的药理学治疗。 方法：对当前的纳米系统进行了广泛的综述，例如针对阿尔茨海默氏病，血管性痴呆和混合性痴呆的脑部药物输送系统。此外，也报道了纳米热疗作为此类痴呆症的可能成像标志。 结果：鉴于纳米级药物输送系统很容易穿透血脑屏障并在体内循环较长时间，因此纳米技术领域对于靶向痴呆非常有利。这些纳米制剂由聚合物纳米颗粒，固体脂质纳米颗粒，纳米结构脂质载体，微乳液，纳米乳液和液晶组成。纳米治疗剂的递送可以通过各种给药途径来实现，例如透皮，注射，口服，更重要的是，通过鼻内途径。然而，纳米载体主要限于针对阿尔茨海默氏病的疾病。因此，应开发用于其他类型痴呆的纳米载体。 结论：总而言之，了解神经退行性病变的机理并审查当前针对阿尔茨海默氏病和其他痴呆类型的药物递送系统对于医学和药学界产生有效的治疗选择和基于多功能和生物相容性纳米载体的新颖策略具有重要意义，这些纳米载体可以递送药物充分进入大脑

关键词: 痴呆，老年痴呆症，脑部药物递送，纳米技术，纳米颗粒，微乳剂，脂质纳米载体。

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