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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Review Article

Fast Dissolution Electrospun Medicated Nanofibers for Effective Delivery of Poorly Water-Soluble Drug

Author(s): Yrysbaeva Aidana, Yibin Wang, Jie Li, Shuyue Chang, Ke Wang* and Deng-Guang Yu*

Volume 19, Issue 4, 2022

Published on: 03 January, 2022

Page: [422 - 435] Pages: 14

DOI: 10.2174/1567201818666210215110359

Price: $65

Abstract

Background: Electrospinning is developing rapidly from an earlier laboratory method into an industrial process. The clinical applications of this technique are approached in various ways through electrospun medicated nanofibers. Fast-dissolving oral drug delivery systems (DDSs) have promising commercial applications in the near future.

Methods: Related papers have been investigated in this study, including the latest research results on electrospun nanofiber-based fast-dissolution DDSs.

Results: The following related topics are concluded: 1) development of electrospinning, ranging from one-fluid blending to multi-fluid process and potential applications in the formation of medicated nanofibers involving poorly water-soluble drugs; 2) selection of appropriate polymer matrices and drug carriers for filament formation; 3) types of poorly water-soluble drugs ideal for fast oral delivery; 4) methods for evaluating fast-dissolving nanofibers; 5) mechanisms that promote the fast dissolution of poorly water-soluble drugs by electrospun nanofibers; 6) and important issues related to further development of electrospun medicated nanofibers as oral fast-dissolving drug delivery systems.

Conclusion and Perspective: Given their unique properties, electrospun-medicated nanofibers can be used as oral fast-dissolving DDSs of poorly water-soluble drugs. However, significant issues, such as scalable productions and solid dosage form conversions, need to be investigated.

Keywords: Electrospinning, electrospun medicated nanofibers, fast-dissolution, drug delivery system, poorly water-soluble drug, amorphous.

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Graphical Abstract

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