Formulation of Nanosuspensions of Albendazole for Oral Administration

Yamasani   Madhusudan   Rao; Mittapalli   Pavan   Kumar; Shashank      Apte

doi:10.2174/157341308783591807

Abstract

Poorly water-soluble compounds like albendazole with dissolution limited bioavailability need novel approaches for enhancement of bioavailability and therapeutic efficacy. The use of nanosuspension approach offers an opportunity to address the issues associated with BCS class II molecules. High pressure homogenization technique can be employed to produce drug nanocrystals with a number of advantages in comparison to other techniques such as nanoprecipitation, sonication, milling and high speed homogenization. The present study shows the feasibility of formulating a stable formulation of albendazole with minimum particle size through high pressure homogenization technique. To point out the influence and importance of identifying right stabilizer (s) and process parameters the studies such as influence of number of homogenizing cycles on particle size, sequence of mixing of ingredients on the physical characteristics of nanosuspensions and desorption studies was done. Selected nanosuspension formulations containing different stabilizers were lyophilized to convert into solid dosage forms. These studies had indicated that the aqueous dispersion of drug nanoparticles could be converted into stable solid dosage forms with out affecting the size on reconstitution.

Keywords: Albendazole, nanosuspension, zeta potential, high pressure homogenization, polysorbate 80, lyophilization

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