新型含氮类固醇衍生物治疗前列腺癌

Title:Novel Nitrogen Containing Steroid Derivatives for Prostate Cancer Treatment

Volume: 28 Issue: 40

关键词: 前列腺癌，类固醇CYP17A1抑制剂，阿比特龙，galeterone，新型氮，抗前列腺癌药物，雄激素剥夺疗法。

摘要: This mini-review focuses on the investigation of novel nitrogen-containing steroid derivatives that are potentially applicable for prostate cancer treatment. It covers the literature of the last decade, highlighting the structure of new steroid compounds that exhibit significant activity in prostate cancer cells and possess pharmacological potency. New derivatives of known anti-prostate cancer agents: abiraterone and galeterone, new derivatives of androstane and pregnane modified with nitrogen-containing heterocycles, and some related steroid-derived compounds are discussed in the review.

Cite this article as:

Novel Nitrogen Containing Steroid Derivatives for Prostate Cancer Treatment, Current Medicinal Chemistry 2021; 28 (40) . https://dx.doi.org/10.2174/0929867328666210208113919