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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Synthesis, Characterization, and Antimicrobial Evaluation of New Furan-2-Carboxamide Derivatives

Author(s): Kamal Sweidan*, Gada Idrees, Luay Abu-Qatouseh, Muhammad Nawaz Tahir, Monther Khanfar, Rajendra Joshi, Eyad Mallah and Mohammsad S. Mubarak

Volume 19, Issue 4, 2022

Published on: 25 January, 2021

Page: [314 - 325] Pages: 12

DOI: 10.2174/1570178618666210125161436

Price: $65

Abstract

A new series of furan-2-carboxamide and 5-bromofuran-2-carboxamide derivatives have been prepared in good yields using simple procedures. Our strategy was to synthesize compounds containing functional groups that are known to exhibit significant bioactivity, such as amide (8-15), 2,4- dinitrophenylhydrazone (8a-15a), and thiosemicarbazone (8b-15b). These newly synthesized compounds have been characterized with the aid of a number of spectroscopic techniques, including 1HNMR, 13C-NMR, IR, and mass spectrometry, in addition two x-ray structures were measured. Antibacterial and antifungal activity of prepared compounds was investigated; antifungal results indicated that compound 8a is the most active, whereas compounds 15 and 9b showed moderate activity. Similarly, results of antibacterial testing revealed that most of the prepared compounds exhibit low activity, while compounds containing 2,4-dinitrophenylhydrazone moiety (9a-14a) are the most active towards E. Coli strain.

Keywords: Antimicrobial, furan-2-carboxamide, synthesis, schiff bases.

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