Abstract
Changes in human lifestyles and environmental deterioration globally cause the emergence of new viruses, posing research challenges. The outburst of COVID-19 (nCoV19) is a recent example, wherein effective management of virus, using the conventional medication and effective diagnostic measures is a challenge. While many ongoing strategies from vaccine development to drug repurposing are currently being investigated, a targeted approach with nanotechnology can be helpful to meet the demand for preventive and diagnostic measures. The significant results of nanotechnology in providing better efficacy of pharmaceutical drugs is expected to combat nCoV19 by using nanotechnology- based solutions, preventive treatment, and diagnosis. This article addresses the dire need for nanotechnology-based solutions in the current pandemic, as well as analyzes the ongoing innovation and existing patents that can be used to provide better solutions. Multiple applications of nanotechnology are considered to be helpful in preventive and diagnostic measures, immune response modulation, and immunity boosters, along with projecting a pathway for industry and academic researchers for addressing such a pandemic.
Keywords: Nanotechnology, anti-viral, nano-coating, coronavirus, COVID-19, preventive measures, research, technology transfer.
Graphical Abstract
[http://dx.doi.org/10.1128/MMBR.00004-08 ] [PMID: 18772285]
[http://dx.doi.org/10.1007/978-1-4939-2438-7_1 ] [PMID: 25720466]
[http://dx.doi.org/10.3390/jcm9020488]
[http://dx.doi.org/10.1146/annurev-virology-012420-022445]
[http://dx.doi.org/10.1016/j.jceh.2020.04.020 ] [PMID: 32377058]
[http://dx.doi.org/10.1016/j.antiviral.2017.11.001 ] [PMID: 29128390]
[http://dx.doi.org/10.1371/journal.ppat.1007236 ] [PMID: 30102747]
[http://dx.doi.org/10.1002/jmv.25719 ] [PMID: 32083328]
[PMID: 32294809]
[PMID: 32171193]
[http://dx.doi.org/10.1016/j.jtho.2020.02.010 ] [PMID: 32114094]
[http://dx.doi.org/10.7326/M20-0533 ] [PMID: 32163542]
[http://dx.doi.org/10.1002/cti2.1136 ] [PMID: 32382418]
[http://dx.doi.org/10.1007/s12519-020-00343-7 ] [PMID: 32034659]
[http://dx.doi.org/10.1016/j.tmaid.2020.101647 ] [PMID: 32247927]
[http://dx.doi.org/10.1007/s40495-020-00216-7 ] [PMID: 32395418]
[http://dx.doi.org/10.1056/NEJMoa1910993 ] [PMID: 31774950]
[http://dx.doi.org/10.1038/s41422-020-0282-0 ] [PMID: 32020029]
[http://dx.doi.org/10.1128/JCM.00512-20 ] [PMID: 32245835]
[http://dx.doi.org/10.1038/s41423-020-0407-x ] [PMID: 32235915]
[http://dx.doi.org/10.1016/j.pep.2016.02.013 ] [PMID: 26917227]
[http://dx.doi.org/10.1086/591851 ] [PMID: 19067613]
[http://dx.doi.org/10.1086/499406 ] [PMID: 16355321]
[http://dx.doi.org/10.1056/NEJMoa2001316 ] [PMID: 31995857]
[http://dx.doi.org/10.1021/acsnano.0c02624 ] [PMID: 32223179]
[http://dx.doi.org/10.1056/NEJMoa2001282 ] [PMID: 32187464]
[http://dx.doi.org/10.1007/s11095-005-7147-6 ] [PMID: 16132350]
[http://dx.doi.org/10.1016/S2055-6640(20)30489-1 ] [PMID: 26430703]
[http://dx.doi.org/10.2147/IJN.S25871 ] [PMID: 23055735]
[http://dx.doi.org/10.1038/srep24867 ] [PMID: 27113197]
[http://dx.doi.org/10.1021/acs.molpharmaceut.5b00335 ] [PMID: 26524196]
[http://dx.doi.org/10.1021/acs.analchem.6b03109 ] [PMID: 27726379]
[http://dx.doi.org/10.1016/j.biopha.2006.07.093 ] [PMID: 16952435]
[http://dx.doi.org/10.4161/viru.2.5.17035 ] [PMID: 21921677]
[http://dx.doi.org/10.1146/annurev-virology-110615-042301 ] [PMID: 27578435]
[http://dx.doi.org/10.1007/s12551-020-00653-0 ] [PMID: 32140918]
[http://dx.doi.org/10.1155/2020/4297937]
[http://dx.doi.org/10.1016/j.molstruc.2020.128107]
[http://dx.doi.org/10.1177/2049936117713593 ] [PMID: 28748089]
[http://dx.doi.org/10.1016/j.jconrel.2016.01.008 ] [PMID: 26772877]
[http://dx.doi.org/10.1016/j.ijpharm.2009.10.018 ] [PMID: 19825408]
[http://dx.doi.org/10.1039/c2cc33448h ] [PMID: 22798998]
[http://dx.doi.org/10.1080/10611860600965914 ] [PMID: 17365278]
[http://dx.doi.org/10.1002/anie.200904359 ] [PMID: 20401880]
[http://dx.doi.org/10.4314/tjpr.v8i3.44547]
[http://dx.doi.org/10.2174/157341309787314566]
[http://dx.doi.org/10.1021/bi800622t ] [PMID: 18540634]
[http://dx.doi.org/10.1111/j.1747-0285.2008.00746.x ] [PMID: 19152635]
[http://dx.doi.org/10.1021/acsnano.0c02857 ] [PMID: 32286790]
[http://dx.doi.org/10.1186/s12917-015-0481-y ] [PMID: 26293453]
[PMID: 21034678]
[http://dx.doi.org/10.1016/j.envres.2020.109819 ] [PMID: 32569870]
[http://dx.doi.org/10.1016/j.envint.2020.105730 ] [PMID: 32294574]
[http://dx.doi.org/10.1073/pnas.2009637117 ] [PMID: 32527856]
[http://dx.doi.org/10.3390/ijms20153620 ] [PMID: 31344881]
[http://dx.doi.org/10.1515/ntrev-2016-0054]
[PMID: 32366816]
[http://dx.doi.org/10.2174/1381612826666200720233947 ] [PMID: 32693757]