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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

弥漫性大 B 细胞淋巴瘤 (DLBCL) 治疗抵抗的表观遗传机制

卷 21, 期 4, 2021

发表于: 06 January, 2021

页: [274 - 282] 页: 9

弟呕挨: 10.2174/1568009620666210106122750

价格: $65

摘要

弥漫性大 B 细胞淋巴瘤 (DLBCL) 是非霍奇金 B 细胞淋巴瘤 (NHL) 中最常见的组织学亚型，表现出高度异质的遗传/表型特征以及对常规免疫化疗的不同反应。 DLBCL 患者的遗传分析揭示了表观遗传调节基因的高度重复突变，如 CREBBP、KMT2D、EZH2 和 TET2。这些突变通过 B 细胞的异常表观遗传编程驱动恶性转化，并可能影响临床结果。这些和其他染色质修饰基因在正常 B 细胞中也起着关键作用，因为它们经历了体液免疫反应特有的各种表型转变。其中许多功能与损害免疫监视有关，并且可能会严重介导对免疫疗法的抵抗。在这篇综述中，我们描述了表观遗传功能障碍如何诱导淋巴瘤发生，并讨论了实施精确表观遗传疗法以逆转这些免疫抵抗表型的方法。

关键词: 弥漫性大 B 细胞淋巴瘤 (DLBCL)、表观遗传学、cREBBP、eP300、kMT2D、eZH2、TET2、表观遗传异质性。

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图形摘要

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