Abstract
Background: The present study outlines the green synthesis of copper oxide (GS-CuO) nanoparticles using Magnolia champaca plant floral extract for the first time. Computational analysis showed the role of GS-CuO nanoparticles on cardiac enzymes ACE2 and SOD1 functional expression through hydrogen bond interaction with amino acid residues
Method: The synthesized GS-CuO nanoparticles were characterized by various techniques like XRay Diffraction, UV-Vis Spectrophotometer, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Transmission Electron Microscopy
Results: Nanoparticles demonstrate the presence of spherical shape and size 20 nm. The particles have many active sites as compared to the bulk materials, and thus, computational analysis was conducted against angiotensin-converting enzyme and superoxide dismutase to visualize the cardioprotective effects
Conclusion: The in-silico approach established valuable information on the cardioprotective effects of green synthesized oxide nanoparticles using Magnolia champaca.
Keywords: GS-CuO nanoparticles, magnolia champaca, GCMS, TEM, in-silico approach, LigPlot
Graphical Abstract
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