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Review Article

用于癌症治疗的两亲性聚乙二醇化药物的自组装胶束

卷 22, 期 8, 2021

发表于: 31 December, 2020

页: [870 - 881] 页: 12

弟呕挨: 10.2174/1389450122666201231130702

价格: $65

摘要

通常，化疗药物的溶解度差和不精确递送会损害其临床癌症治疗的功效。为了解决这些问题，将水溶性较差的药物与聚乙二醇（PEG）偶联得到聚乙二醇化药物，该药物具有提高的水溶性，并且还可以在水溶液中自组装形成胶束（PEGylated drug micelles）。 ）。表面 PEG 层增强了胶束的胶体稳定性并减少了与生理环境的相互作用。同时，与游离药物相比，聚乙二醇化药物胶束通过增强渗透和保留 (EPR) 效应实现肿瘤靶向，以提高抗肿瘤功效。聚乙二醇化药物胶束以药物作为载体介质的一部分，相对增加了胶束的载药量。刺激响应性聚乙二醇化药物胶束的发展促进了药物释放的智能和可控性。此外，聚乙二醇化药物胶束在克服多药耐药（MDR）、血管生成、免疫抑制等癌症治疗挑战方面显示出巨大潜力。在这篇综述中，我们重点介绍了聚乙二醇化药物胶束的研究进展，包括结构和性质、智能刺激响应型聚乙二醇化药物胶束，以及聚乙二醇化药物胶束所克服的挑战。

关键词: 胶束、聚乙二醇化药物、癌症治疗、刺激响应、血管生成、多药耐药、血脑屏障、免疫抑制。

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