Chagas Disease and Coumarins: A Review of Natural and Synthetic Coumarins As Anti-Trypanosoma Cruzi Agents

Title:Chagas Disease and Coumarins: A Review of Natural and Synthetic Coumarins As Anti-Trypanosoma Cruzi Agents

Volume: 21 Issue: 13

Author(s): Guilherme Arraché Gonçalves*, Hugo Cerecetto, Gilsane Lino von Poser, Rômulo Faria Santos Canto and Vera Lucia Eifler-Lima*

Affiliation:

• Laboratorio de Síntese Organica Medicinal (LaSOM), Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS,Brazil

• Laboratorio de Síntese Organica Medicinal (LaSOM), Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS,Brazil

Keywords: Chagas disease, neglected tropical diseases, Trypanosoma cruzi, Trypanosoma cruzi targets, natural coumarins, synthetic coumarins.

Abstract: The complexity of Chagas disease is still a challenge in endemic regions and an emergent public health problem in non-endemic countries. The causative agent of this neglected tropical disease, Trypanosoma cruzi, is mainly transmitted by triatomine vectors and possesses multiple epidemiologically important strains. Current chemotherapeutics are outdated and their limited efficacy is one of the major reasons for treatment discontinuation. In this context, the development of novel, safe and economically accessible antichagasic drugs is required. Various classes of heterocycles and natural compounds have been described as potential antichagasic scaffolds, and coumarins are no exception. These versatile compounds have a wide spectrum of biological activities, and numerous natural and synthetic coumarins have been reported with antichagasic potential. This review aims to discuss the available literature between 2001 and 2020 regarding natural and synthetic coumarins with anti- Trypanosoma cruzi activity. Moreover, some of the studies herein comprised are dedicated to the potential of coumarins to inhibit promising targets in Trypanosoma cruzi.

Cite this article as:

Gonçalves Arraché Guilherme *, Cerecetto Hugo, Poser Lino von Gilsane, Canto Faria Santos Rômulo and Eifler-Lima Lucia Vera*, Chagas Disease and Coumarins: A Review of Natural and Synthetic Coumarins As Anti-Trypanosoma Cruzi Agents, Mini-Reviews in Medicinal Chemistry 2021; 21 (13) . https://dx.doi.org/10.2174/1389557521666201229125931