Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug

Title: Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug

Volume: 8 Issue: 2

Author(s): Maurizio Bifulco, Anna Maria Malfitano, Maria Chiara Proto, Antonietta Santoro, Maria Gabriella Caruso and Chiara Laezza

Affiliation:

Keywords: N6-Isopentenyladenosine, apoptosis, cancer

Abstract: A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6-Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary clinical observation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug.

Cite this article as:

Bifulco Maurizio, Malfitano Maria Anna, Proto Chiara Maria, Santoro Antonietta, Caruso Gabriella Maria and Laezza Chiara, Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/187152008783497028