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Research Article

产抗龋齿的核多角体病毒作为哺乳动物基因治疗的载体的评价

卷 21, 期 2, 2021

发表于: 17 December, 2020

页: [177 - 189] 页: 13

弟呕挨: 10.2174/1566523220999201217155945

价格: $65

摘要

背景：杆状病毒是具有重要生物技术应用的昆虫病原体，已超越了其作为农业害虫的生物控制剂的范围。一种物种，加利福尼亚州的苜蓿芽孢杆菌多核多角体病毒（AcMNPV）已被广泛用作生产重组蛋白的分子平台和哺乳动物基因的传递载体，因为它可以转导广泛的哺乳动物细胞和组织而无需复制或产生后代。 方法：为了研究抗龋齿双核多角体病毒（AgMNPV）物种的萌芽病毒体是否具有相同的能力，通过同源重组将病毒基因组修饰为易感昆虫细胞以整合报告基因，然后在哺乳动物细胞系中进行比较关于源自AcMNPV的等效病毒的表格。此外，测定了AgMNPV病毒粒子在哺乳动物中的复制能力。 结果：进行的实验表明，AgMNPV的重组变体可以转导并支持所传递基因的表达，但不能在哺乳动物细胞中复制。 结论：因此，该昆虫病原体被提议作为人类非感染性病毒的替代品，以探索基于哺乳动物细胞的基因治疗和其他应用中的新方法。

关键词: 杆状病毒，AgMNPV，AcMNPV，BacMam，转导，基因治疗。

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