The Antioxidant Response as a Drug Target in Diabetic Neuropathy

Title: The Antioxidant Response as a Drug Target in Diabetic Neuropathy

Volume: 9 Issue: 1

Author(s): Andrea M. Vincent, James L. Edwards, Mahdieh Sadidi and Eva L. Feldman

Affiliation:

Keywords: dorsal root ganglia, Nrf2 protein, hyperglycemia, oxidative stress, advanced glycation products

Abstract: While increasing antioxidant potential is an attractive treatment strategy for diabetic neuropathy, many years of trials using high-dose oral antioxidants have not produced therapeutic results. An increasing understanding of the innate antioxidant response and the pharmacological agents that can regulate this mechanism may open new avenue for drug development. This review describes the current state of antioxidant trials and the potential for targeting the antioxidant response. In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes.

Cite this article as:

Vincent M. Andrea, Edwards L. James, Sadidi Mahdieh and Feldman L. Eva, The Antioxidant Response as a Drug Target in Diabetic Neuropathy, Current Drug Targets 2008; 9 (1) . https://dx.doi.org/10.2174/138945008783431754